Whi5 phosphorylation embedded in the G1/S network dynamically controls critical cell size and cell fate

In budding yeast the G1/S transition requires the attainment of a critical cell size. Here the authors unravel its basic control mechanism by integrating simulations of a mathematical model of multisite phosphorylation of Whi5 by Cln3–Cdk1, with molecular analyses of a Whi5 phospho-mimetic mutant.

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Autores principales: Pasquale Palumbo, Marco Vanoni, Valerio Cusimano, Stefano Busti, Francesca Marano, Costanzo Manes, Lilia Alberghina
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/2240802c65824c75adef5680efa06b5b
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