Identification of potential therapeutic antimicrobial peptides against Acinetobacter baumannii in a mouse model of pneumonia

Abstract Acinetobacter baumannii-induced nosocomial pneumonia has become a serious clinical problem because of high antibiotic resistance rates. Antimicrobial peptides (AMP) are an ideal alternative strategy due to their broad-spectrum of antimicrobial activity and low incidence of bacterial resista...

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Autores principales:	Chiau-Jing Jung, You-Di Liao, Chih-Chieh Hsu, Ting-Yu Huang, Yu-Chung Chuang, Jeng-Wei Chen, Yu-Min Kuo, Jean-San Chia
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2244d652ad7845d298bd77fbf17539f3
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spelling	oai:doaj.org-article:2244d652ad7845d298bd77fbf17539f32021-12-02T14:23:32ZIdentification of potential therapeutic antimicrobial peptides against Acinetobacter baumannii in a mouse model of pneumonia10.1038/s41598-021-86844-52045-2322https://doaj.org/article/2244d652ad7845d298bd77fbf17539f32021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86844-5https://doaj.org/toc/2045-2322Abstract Acinetobacter baumannii-induced nosocomial pneumonia has become a serious clinical problem because of high antibiotic resistance rates. Antimicrobial peptides (AMP) are an ideal alternative strategy due to their broad-spectrum of antimicrobial activity and low incidence of bacterial resistance. However, their application is limited by toxicity and stability in vivo. The present study used a mouse model to directly identify potential AMPs effective for treatment of A. baumannii-induced pneumonia. Fifty-eight AMPs were screened and two identified (SMAP-29 and TP4) to have prophylactic effects which prevented the death of mice with pneumonia. Furthermore, two TP4 derivatives (dN4 and dC4) were found to have therapeutic activity in pneumonia mouse models by peritoneal or intravenous administration. Both dN4 and dC4 also inhibited and/or eliminated A. baumannii biofilms at higher doses. Taken together, these data suggest the AMP derivatives dN4 and dC4 represent a potential treatment strategy for A. baumannii-induced pneumonia.Chiau-Jing JungYou-Di LiaoChih-Chieh HsuTing-Yu HuangYu-Chung ChuangJeng-Wei ChenYu-Min KuoJean-San ChiaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chiau-Jing Jung You-Di Liao Chih-Chieh Hsu Ting-Yu Huang Yu-Chung Chuang Jeng-Wei Chen Yu-Min Kuo Jean-San Chia Identification of potential therapeutic antimicrobial peptides against Acinetobacter baumannii in a mouse model of pneumonia
description	Abstract Acinetobacter baumannii-induced nosocomial pneumonia has become a serious clinical problem because of high antibiotic resistance rates. Antimicrobial peptides (AMP) are an ideal alternative strategy due to their broad-spectrum of antimicrobial activity and low incidence of bacterial resistance. However, their application is limited by toxicity and stability in vivo. The present study used a mouse model to directly identify potential AMPs effective for treatment of A. baumannii-induced pneumonia. Fifty-eight AMPs were screened and two identified (SMAP-29 and TP4) to have prophylactic effects which prevented the death of mice with pneumonia. Furthermore, two TP4 derivatives (dN4 and dC4) were found to have therapeutic activity in pneumonia mouse models by peritoneal or intravenous administration. Both dN4 and dC4 also inhibited and/or eliminated A. baumannii biofilms at higher doses. Taken together, these data suggest the AMP derivatives dN4 and dC4 represent a potential treatment strategy for A. baumannii-induced pneumonia.
format	article
author	Chiau-Jing Jung You-Di Liao Chih-Chieh Hsu Ting-Yu Huang Yu-Chung Chuang Jeng-Wei Chen Yu-Min Kuo Jean-San Chia
author_facet	Chiau-Jing Jung You-Di Liao Chih-Chieh Hsu Ting-Yu Huang Yu-Chung Chuang Jeng-Wei Chen Yu-Min Kuo Jean-San Chia
author_sort	Chiau-Jing Jung
title	Identification of potential therapeutic antimicrobial peptides against Acinetobacter baumannii in a mouse model of pneumonia
title_short	Identification of potential therapeutic antimicrobial peptides against Acinetobacter baumannii in a mouse model of pneumonia
title_full	Identification of potential therapeutic antimicrobial peptides against Acinetobacter baumannii in a mouse model of pneumonia
title_fullStr	Identification of potential therapeutic antimicrobial peptides against Acinetobacter baumannii in a mouse model of pneumonia
title_full_unstemmed	Identification of potential therapeutic antimicrobial peptides against Acinetobacter baumannii in a mouse model of pneumonia
title_sort	identification of potential therapeutic antimicrobial peptides against acinetobacter baumannii in a mouse model of pneumonia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2244d652ad7845d298bd77fbf17539f3
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Identification of potential therapeutic antimicrobial peptides against Acinetobacter baumannii in a mouse model of pneumonia

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