Clinical significance of microRNA-1180-3p for colorectal cancer and effect of its alteration on cell function: Short title: Role of miR-1180-3p in CRC

An early diagnosis and effective prognostic factors would greatly reduce the mortality rate of colorectal cancer (CRC). This research is intended to complete the evaluation of the prognostic value and potential role of miR-1180-3p in CRC. The miR-1180-3p levels were reduced in CRC patients’ tissues,...

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Autores principales:	Chunlei Li, Dewei Zhang, Shoujin Tian
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	colorectal cancer mir-1180-3p prognosis growth mobility Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/224885ea7b8c46b3b32219d202507571
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spelling	oai:doaj.org-article:224885ea7b8c46b3b32219d2025075712021-11-04T15:51:54ZClinical significance of microRNA-1180-3p for colorectal cancer and effect of its alteration on cell function: Short title: Role of miR-1180-3p in CRC2165-59792165-598710.1080/21655979.2021.1997694https://doaj.org/article/224885ea7b8c46b3b32219d2025075712021-11-01T00:00:00Zhttp://dx.doi.org/10.1080/21655979.2021.1997694https://doaj.org/toc/2165-5979https://doaj.org/toc/2165-5987An early diagnosis and effective prognostic factors would greatly reduce the mortality rate of colorectal cancer (CRC). This research is intended to complete the evaluation of the prognostic value and potential role of miR-1180-3p in CRC. The miR-1180-3p levels were reduced in CRC patients’ tissues, blood, and human CRC cell lines. The ability of miR-1180-3p was explored in discrimination of CRC patients and healths and the value in overall survival estimate. The effect of miR-1180-3p dysregulation on the CRC cellular function was investigated. miR-1180-3p is downregulated in CRC tissues, blood and cells than normal ones. This lower expression was correlated with vascular invasion, lymph node metastasis, and TNM stage. With the use of ROC curve, miR-1180-3p showed discriminating ability in CRC patients and healthy subjects. With the result of Kaplan-Meier analysis and multi- Multivariate Cox analysis, miR-1180-3p was an independent predictor for CRC patients’ overall survival. Utilizing CCK-8, Transwell and matrigel assays, overexpression of miR-1180-3p reduced cancer cell proliferation and mobility, but induced apoptosis, by targeting COL12A1. miR-1180-3p might function as a suppressor in CRC progression and allowed the discovery of a new biomarker for diagnosis, prognosis and therapy target for CRC.Chunlei LiDewei ZhangShoujin TianTaylor & Francis Grouparticlecolorectal cancermir-1180-3pprognosisgrowthmobilityBiotechnologyTP248.13-248.65ENBioengineered, Vol 0, Iss 0 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	colorectal cancer mir-1180-3p prognosis growth mobility Biotechnology TP248.13-248.65
spellingShingle	colorectal cancer mir-1180-3p prognosis growth mobility Biotechnology TP248.13-248.65 Chunlei Li Dewei Zhang Shoujin Tian Clinical significance of microRNA-1180-3p for colorectal cancer and effect of its alteration on cell function: Short title: Role of miR-1180-3p in CRC
description	An early diagnosis and effective prognostic factors would greatly reduce the mortality rate of colorectal cancer (CRC). This research is intended to complete the evaluation of the prognostic value and potential role of miR-1180-3p in CRC. The miR-1180-3p levels were reduced in CRC patients’ tissues, blood, and human CRC cell lines. The ability of miR-1180-3p was explored in discrimination of CRC patients and healths and the value in overall survival estimate. The effect of miR-1180-3p dysregulation on the CRC cellular function was investigated. miR-1180-3p is downregulated in CRC tissues, blood and cells than normal ones. This lower expression was correlated with vascular invasion, lymph node metastasis, and TNM stage. With the use of ROC curve, miR-1180-3p showed discriminating ability in CRC patients and healthy subjects. With the result of Kaplan-Meier analysis and multi- Multivariate Cox analysis, miR-1180-3p was an independent predictor for CRC patients’ overall survival. Utilizing CCK-8, Transwell and matrigel assays, overexpression of miR-1180-3p reduced cancer cell proliferation and mobility, but induced apoptosis, by targeting COL12A1. miR-1180-3p might function as a suppressor in CRC progression and allowed the discovery of a new biomarker for diagnosis, prognosis and therapy target for CRC.
format	article
author	Chunlei Li Dewei Zhang Shoujin Tian
author_facet	Chunlei Li Dewei Zhang Shoujin Tian
author_sort	Chunlei Li
title	Clinical significance of microRNA-1180-3p for colorectal cancer and effect of its alteration on cell function: Short title: Role of miR-1180-3p in CRC
title_short	Clinical significance of microRNA-1180-3p for colorectal cancer and effect of its alteration on cell function: Short title: Role of miR-1180-3p in CRC
title_full	Clinical significance of microRNA-1180-3p for colorectal cancer and effect of its alteration on cell function: Short title: Role of miR-1180-3p in CRC
title_fullStr	Clinical significance of microRNA-1180-3p for colorectal cancer and effect of its alteration on cell function: Short title: Role of miR-1180-3p in CRC
title_full_unstemmed	Clinical significance of microRNA-1180-3p for colorectal cancer and effect of its alteration on cell function: Short title: Role of miR-1180-3p in CRC
title_sort	clinical significance of microrna-1180-3p for colorectal cancer and effect of its alteration on cell function: short title: role of mir-1180-3p in crc
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/224885ea7b8c46b3b32219d202507571
work_keys_str_mv	AT chunleili clinicalsignificanceofmicrorna11803pforcolorectalcancerandeffectofitsalterationoncellfunctionshorttitleroleofmir11803pincrc AT deweizhang clinicalsignificanceofmicrorna11803pforcolorectalcancerandeffectofitsalterationoncellfunctionshorttitleroleofmir11803pincrc AT shoujintian clinicalsignificanceofmicrorna11803pforcolorectalcancerandeffectofitsalterationoncellfunctionshorttitleroleofmir11803pincrc
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Clinical significance of microRNA-1180-3p for colorectal cancer and effect of its alteration on cell function: Short title: Role of miR-1180-3p in CRC

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