Full-field MRI measurements of in-vivo positional brain shift reveal the significance of intra-cranial geometry and head orientation for stereotactic surgery

Abstract Positional brain shift (PBS), the sagging of the brain under the effect of gravity, is comparable in magnitude to the margin of error for the success of stereotactic interventions ( $$\sim $$ ∼ 1 mm). This non-uniform shift due to slight differences in head orientation can lead to a signif...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Stefano Zappalá, Nicholas J. Bennion, Matthew R. Potts, Jing Wu, Slawomir Kusmia, Derek K. Jones, Sam L. Evans, David Marshall
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2248f80b688f4bfb87b1e011e0d47071
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2248f80b688f4bfb87b1e011e0d47071
record_format	dspace
spelling	oai:doaj.org-article:2248f80b688f4bfb87b1e011e0d470712021-12-02T19:09:20ZFull-field MRI measurements of in-vivo positional brain shift reveal the significance of intra-cranial geometry and head orientation for stereotactic surgery10.1038/s41598-021-97150-52045-2322https://doaj.org/article/2248f80b688f4bfb87b1e011e0d470712021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97150-5https://doaj.org/toc/2045-2322Abstract Positional brain shift (PBS), the sagging of the brain under the effect of gravity, is comparable in magnitude to the margin of error for the success of stereotactic interventions ( $$\sim $$ ∼ 1 mm). This non-uniform shift due to slight differences in head orientation can lead to a significant discrepancy between the planned and the actual location of surgical targets. Accurate in-vivo measurements of this complex deformation are critical for the design and validation of an appropriate compensation to integrate into neuronavigational systems. PBS arising from prone-to-supine change of head orientation was measured with magnetic resonance imaging on 11 young adults. The full-field displacement was extracted on a voxel-basis via digital volume correlation and analysed in a standard reference space. Results showed the need for target-specific correction of surgical targets, as a significant displacement ranging from 0.52 to 0.77 mm was measured at surgically relevant structures. Strain analysis further revealed local variability in compressibility: anterior regions showed expansion (both volume and shape change), whereas posterior regions showed small compression, mostly dominated by shape change. Finally, analysis of correlation demonstrated the potential for further patient- and intervention-specific adjustments, as intra-cranial breadth and head tilt correlated with PBS reaching statistical significance.Stefano ZappaláNicholas J. BennionMatthew R. PottsJing WuSlawomir KusmiaDerek K. JonesSam L. EvansDavid MarshallNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Stefano Zappalá Nicholas J. Bennion Matthew R. Potts Jing Wu Slawomir Kusmia Derek K. Jones Sam L. Evans David Marshall Full-field MRI measurements of in-vivo positional brain shift reveal the significance of intra-cranial geometry and head orientation for stereotactic surgery
description	Abstract Positional brain shift (PBS), the sagging of the brain under the effect of gravity, is comparable in magnitude to the margin of error for the success of stereotactic interventions ( $$\sim $$ ∼ 1 mm). This non-uniform shift due to slight differences in head orientation can lead to a significant discrepancy between the planned and the actual location of surgical targets. Accurate in-vivo measurements of this complex deformation are critical for the design and validation of an appropriate compensation to integrate into neuronavigational systems. PBS arising from prone-to-supine change of head orientation was measured with magnetic resonance imaging on 11 young adults. The full-field displacement was extracted on a voxel-basis via digital volume correlation and analysed in a standard reference space. Results showed the need for target-specific correction of surgical targets, as a significant displacement ranging from 0.52 to 0.77 mm was measured at surgically relevant structures. Strain analysis further revealed local variability in compressibility: anterior regions showed expansion (both volume and shape change), whereas posterior regions showed small compression, mostly dominated by shape change. Finally, analysis of correlation demonstrated the potential for further patient- and intervention-specific adjustments, as intra-cranial breadth and head tilt correlated with PBS reaching statistical significance.
format	article
author	Stefano Zappalá Nicholas J. Bennion Matthew R. Potts Jing Wu Slawomir Kusmia Derek K. Jones Sam L. Evans David Marshall
author_facet	Stefano Zappalá Nicholas J. Bennion Matthew R. Potts Jing Wu Slawomir Kusmia Derek K. Jones Sam L. Evans David Marshall
author_sort	Stefano Zappalá
title	Full-field MRI measurements of in-vivo positional brain shift reveal the significance of intra-cranial geometry and head orientation for stereotactic surgery
title_short	Full-field MRI measurements of in-vivo positional brain shift reveal the significance of intra-cranial geometry and head orientation for stereotactic surgery
title_full	Full-field MRI measurements of in-vivo positional brain shift reveal the significance of intra-cranial geometry and head orientation for stereotactic surgery
title_fullStr	Full-field MRI measurements of in-vivo positional brain shift reveal the significance of intra-cranial geometry and head orientation for stereotactic surgery
title_full_unstemmed	Full-field MRI measurements of in-vivo positional brain shift reveal the significance of intra-cranial geometry and head orientation for stereotactic surgery
title_sort	full-field mri measurements of in-vivo positional brain shift reveal the significance of intra-cranial geometry and head orientation for stereotactic surgery
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2248f80b688f4bfb87b1e011e0d47071
work_keys_str_mv	AT stefanozappala fullfieldmrimeasurementsofinvivopositionalbrainshiftrevealthesignificanceofintracranialgeometryandheadorientationforstereotacticsurgery AT nicholasjbennion fullfieldmrimeasurementsofinvivopositionalbrainshiftrevealthesignificanceofintracranialgeometryandheadorientationforstereotacticsurgery AT matthewrpotts fullfieldmrimeasurementsofinvivopositionalbrainshiftrevealthesignificanceofintracranialgeometryandheadorientationforstereotacticsurgery AT jingwu fullfieldmrimeasurementsofinvivopositionalbrainshiftrevealthesignificanceofintracranialgeometryandheadorientationforstereotacticsurgery AT slawomirkusmia fullfieldmrimeasurementsofinvivopositionalbrainshiftrevealthesignificanceofintracranialgeometryandheadorientationforstereotacticsurgery AT derekkjones fullfieldmrimeasurementsofinvivopositionalbrainshiftrevealthesignificanceofintracranialgeometryandheadorientationforstereotacticsurgery AT samlevans fullfieldmrimeasurementsofinvivopositionalbrainshiftrevealthesignificanceofintracranialgeometryandheadorientationforstereotacticsurgery AT davidmarshall fullfieldmrimeasurementsofinvivopositionalbrainshiftrevealthesignificanceofintracranialgeometryandheadorientationforstereotacticsurgery
_version_	1718377135368830976

Full-field MRI measurements of in-vivo positional brain shift reveal the significance of intra-cranial geometry and head orientation for stereotactic surgery

Ejemplares similares