Community-acquired bacterial meningitis in alcoholic patients.

<h4>Background</h4>Alcoholism is associated with susceptibility to infectious disease, particularly bacterial pneumonia. In the present study we described characteristics in alcoholic patients with bacterial meningitis and delineate the differences with findings in non-alcoholic adults w...

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Autores principales:	Martijn Weisfelt, Jan de Gans, Arie van der Ende, Diederik van de Beek
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/224b144af26845329d108fc999da9ed0
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spelling	oai:doaj.org-article:224b144af26845329d108fc999da9ed02021-11-25T06:26:02ZCommunity-acquired bacterial meningitis in alcoholic patients.1932-620310.1371/journal.pone.0009102https://doaj.org/article/224b144af26845329d108fc999da9ed02010-02-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20161709/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Alcoholism is associated with susceptibility to infectious disease, particularly bacterial pneumonia. In the present study we described characteristics in alcoholic patients with bacterial meningitis and delineate the differences with findings in non-alcoholic adults with bacterial meningitis.<h4>Methods/principal findings</h4>This was a prospective nationwide observational cohort study including patients aged >16 years who had bacterial meningitis confirmed by culture of cerebrospinal fluid (696 episodes of bacterial meningitis occurring in 671 patients). Alcoholism was present in 27 of 686 recorded episodes of bacterial meningitis (4%) and alcoholics were more often male than non-alcoholics (82% vs 48%, P = 0.001). A higher proportion of alcoholics had underlying pneumonia (41% vs 11% P<0.001). Alcoholics were more likely to have meningitis due to infection with Streptococcus pneumoniae (70% vs 50%, P = 0.01) and Listeria monocytogenes (19% vs 4%, P = 0.005), whereas Neisseria meningitidis was more common in non-alcoholic patients (39% vs 4%, P = 0.01). A large proportion of alcoholics developed complications during clinical course (82% vs 62%, as compared with non-alcoholics; P = 0.04), often cardiorespiratory failure (52% vs 28%, as compared with non-alcoholics; P = 0.01). Alcoholic patients were at risk for unfavourable outcome (67% vs 33%, as compared with non-alcoholics; P<0.001).<h4>Conclusions/significance</h4>Alcoholic patients are at high risk for complications resulting in high morbidity and mortality. They are especially at risk for cardiorespiratory failure due to underlying pneumonia, and therefore, aggressive supportive care may be crucial in the treatment of these patients.Martijn WeisfeltJan de GansArie van der EndeDiederik van de BeekPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 2, p e9102 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Martijn Weisfelt Jan de Gans Arie van der Ende Diederik van de Beek Community-acquired bacterial meningitis in alcoholic patients.
description	<h4>Background</h4>Alcoholism is associated with susceptibility to infectious disease, particularly bacterial pneumonia. In the present study we described characteristics in alcoholic patients with bacterial meningitis and delineate the differences with findings in non-alcoholic adults with bacterial meningitis.<h4>Methods/principal findings</h4>This was a prospective nationwide observational cohort study including patients aged >16 years who had bacterial meningitis confirmed by culture of cerebrospinal fluid (696 episodes of bacterial meningitis occurring in 671 patients). Alcoholism was present in 27 of 686 recorded episodes of bacterial meningitis (4%) and alcoholics were more often male than non-alcoholics (82% vs 48%, P = 0.001). A higher proportion of alcoholics had underlying pneumonia (41% vs 11% P<0.001). Alcoholics were more likely to have meningitis due to infection with Streptococcus pneumoniae (70% vs 50%, P = 0.01) and Listeria monocytogenes (19% vs 4%, P = 0.005), whereas Neisseria meningitidis was more common in non-alcoholic patients (39% vs 4%, P = 0.01). A large proportion of alcoholics developed complications during clinical course (82% vs 62%, as compared with non-alcoholics; P = 0.04), often cardiorespiratory failure (52% vs 28%, as compared with non-alcoholics; P = 0.01). Alcoholic patients were at risk for unfavourable outcome (67% vs 33%, as compared with non-alcoholics; P<0.001).<h4>Conclusions/significance</h4>Alcoholic patients are at high risk for complications resulting in high morbidity and mortality. They are especially at risk for cardiorespiratory failure due to underlying pneumonia, and therefore, aggressive supportive care may be crucial in the treatment of these patients.
format	article
author	Martijn Weisfelt Jan de Gans Arie van der Ende Diederik van de Beek
author_facet	Martijn Weisfelt Jan de Gans Arie van der Ende Diederik van de Beek
author_sort	Martijn Weisfelt
title	Community-acquired bacterial meningitis in alcoholic patients.
title_short	Community-acquired bacterial meningitis in alcoholic patients.
title_full	Community-acquired bacterial meningitis in alcoholic patients.
title_fullStr	Community-acquired bacterial meningitis in alcoholic patients.
title_full_unstemmed	Community-acquired bacterial meningitis in alcoholic patients.
title_sort	community-acquired bacterial meningitis in alcoholic patients.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/224b144af26845329d108fc999da9ed0
work_keys_str_mv	AT martijnweisfelt communityacquiredbacterialmeningitisinalcoholicpatients AT jandegans communityacquiredbacterialmeningitisinalcoholicpatients AT arievanderende communityacquiredbacterialmeningitisinalcoholicpatients AT diederikvandebeek communityacquiredbacterialmeningitisinalcoholicpatients
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Community-acquired bacterial meningitis in alcoholic patients.

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