miRNA142-3p targets Tet2 and impairs Treg differentiation and stability in models of type 1 diabetes

miRNA142-3p targets Tet2 and impairs Treg differentiation and stability in models of type 1 diabetes

miRNA142-3p and Tet2 are separately known to regulate Treg. Here the authors show that miRNA142-3p targets Tet2 and by this opposes Treg differentiation in autoimmune diabetes.

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Autores principales: Martin G. Scherm, Isabelle Serr, Adam M. Zahm, Jonathan Schug, Saverio Bellusci, Rossella Manfredini, Victoria K. Salb, Katharina Gerlach, Benno Weigmann, Anette-Gabriele Ziegler, Klaus H. Kaestner, Carolin Daniel
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/224be2193f454379b9efe6527272f625
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spelling oai:doaj.org-article:224be2193f454379b9efe6527272f6252021-12-02T14:39:56ZmiRNA142-3p targets Tet2 and impairs Treg differentiation and stability in models of type 1 diabetes10.1038/s41467-019-13587-32041-1723https://doaj.org/article/224be2193f454379b9efe6527272f6252019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13587-3https://doaj.org/toc/2041-1723miRNA142-3p and Tet2 are separately known to regulate Treg. Here the authors show that miRNA142-3p targets Tet2 and by this opposes Treg differentiation in autoimmune diabetes.Martin G. SchermIsabelle SerrAdam M. ZahmJonathan SchugSaverio BellusciRossella ManfrediniVictoria K. SalbKatharina GerlachBenno WeigmannAnette-Gabriele ZieglerKlaus H. KaestnerCarolin DanielNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Martin G. Scherm
Isabelle Serr
Adam M. Zahm
Jonathan Schug
Saverio Bellusci
Rossella Manfredini
Victoria K. Salb
Katharina Gerlach
Benno Weigmann
Anette-Gabriele Ziegler
Klaus H. Kaestner
Carolin Daniel
miRNA142-3p targets Tet2 and impairs Treg differentiation and stability in models of type 1 diabetes
description miRNA142-3p and Tet2 are separately known to regulate Treg. Here the authors show that miRNA142-3p targets Tet2 and by this opposes Treg differentiation in autoimmune diabetes.
format article
author Martin G. Scherm
Isabelle Serr
Adam M. Zahm
Jonathan Schug
Saverio Bellusci
Rossella Manfredini
Victoria K. Salb
Katharina Gerlach
Benno Weigmann
Anette-Gabriele Ziegler
Klaus H. Kaestner
Carolin Daniel
author_facet Martin G. Scherm
Isabelle Serr
Adam M. Zahm
Jonathan Schug
Saverio Bellusci
Rossella Manfredini
Victoria K. Salb
Katharina Gerlach
Benno Weigmann
Anette-Gabriele Ziegler
Klaus H. Kaestner
Carolin Daniel
author_sort Martin G. Scherm
title miRNA142-3p targets Tet2 and impairs Treg differentiation and stability in models of type 1 diabetes
title_short miRNA142-3p targets Tet2 and impairs Treg differentiation and stability in models of type 1 diabetes
title_full miRNA142-3p targets Tet2 and impairs Treg differentiation and stability in models of type 1 diabetes
title_fullStr miRNA142-3p targets Tet2 and impairs Treg differentiation and stability in models of type 1 diabetes
title_full_unstemmed miRNA142-3p targets Tet2 and impairs Treg differentiation and stability in models of type 1 diabetes
title_sort mirna142-3p targets tet2 and impairs treg differentiation and stability in models of type 1 diabetes
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/224be2193f454379b9efe6527272f625
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