Malaria parasites both repress host CXCL10 and use it as a cue for growth acceleration

The chemokine CXCL10 is associated with pathogenesis of cerebral malaria in Plasmodium falciparum infection. Here the authors show that P. falciparum produces extracellular vesicles laden with RNAs that are taken up by monocytes resulting in a RIG-I and HUR-1 mediated mechanism of inhibition of CXCL...

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Autores principales:	Yifat Ofir-Birin, Hila Ben Ami Pilo, Abel Cruz Camacho, Ariel Rudik, Anna Rivkin, Or-Yam Revach, Netta Nir, Tal Block Tamin, Paula Abou Karam, Edo Kiper, Yoav Peleg, Reinat Nevo, Aryeh Solomon, Tal Havkin-Solomon, Alicia Rojas, Ron Rotkopf, Ziv Porat, Dror Avni, Eli Schwartz, Thomas Zillinger, Gunther Hartmann, Antonella Di Pizio, Neils Ben Quashie, Rivka Dikstein, Motti Gerlic, Ana Claudia Torrecilhas, Carmit Levy, Esther N. M. Nolte-‘t Hoen, Andrew G. Bowie, Neta Regev-Rudzki
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/224e6a94586f481d8f075fa74b8e8bf3
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spelling	oai:doaj.org-article:224e6a94586f481d8f075fa74b8e8bf32021-12-02T15:07:48ZMalaria parasites both repress host CXCL10 and use it as a cue for growth acceleration10.1038/s41467-021-24997-72041-1723https://doaj.org/article/224e6a94586f481d8f075fa74b8e8bf32021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24997-7https://doaj.org/toc/2041-1723The chemokine CXCL10 is associated with pathogenesis of cerebral malaria in Plasmodium falciparum infection. Here the authors show that P. falciparum produces extracellular vesicles laden with RNAs that are taken up by monocytes resulting in a RIG-I and HUR-1 mediated mechanism of inhibition of CXCL10 protein translation.Yifat Ofir-BirinHila Ben Ami PiloAbel Cruz CamachoAriel RudikAnna RivkinOr-Yam RevachNetta NirTal Block TaminPaula Abou KaramEdo KiperYoav PelegReinat NevoAryeh SolomonTal Havkin-SolomonAlicia RojasRon RotkopfZiv PoratDror AvniEli SchwartzThomas ZillingerGunther HartmannAntonella Di PizioNeils Ben QuashieRivka DiksteinMotti GerlicAna Claudia TorrecilhasCarmit LevyEsther N. M. Nolte-‘t HoenAndrew G. BowieNeta Regev-RudzkiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yifat Ofir-Birin Hila Ben Ami Pilo Abel Cruz Camacho Ariel Rudik Anna Rivkin Or-Yam Revach Netta Nir Tal Block Tamin Paula Abou Karam Edo Kiper Yoav Peleg Reinat Nevo Aryeh Solomon Tal Havkin-Solomon Alicia Rojas Ron Rotkopf Ziv Porat Dror Avni Eli Schwartz Thomas Zillinger Gunther Hartmann Antonella Di Pizio Neils Ben Quashie Rivka Dikstein Motti Gerlic Ana Claudia Torrecilhas Carmit Levy Esther N. M. Nolte-‘t Hoen Andrew G. Bowie Neta Regev-Rudzki Malaria parasites both repress host CXCL10 and use it as a cue for growth acceleration
description	The chemokine CXCL10 is associated with pathogenesis of cerebral malaria in Plasmodium falciparum infection. Here the authors show that P. falciparum produces extracellular vesicles laden with RNAs that are taken up by monocytes resulting in a RIG-I and HUR-1 mediated mechanism of inhibition of CXCL10 protein translation.
format	article
author	Yifat Ofir-Birin Hila Ben Ami Pilo Abel Cruz Camacho Ariel Rudik Anna Rivkin Or-Yam Revach Netta Nir Tal Block Tamin Paula Abou Karam Edo Kiper Yoav Peleg Reinat Nevo Aryeh Solomon Tal Havkin-Solomon Alicia Rojas Ron Rotkopf Ziv Porat Dror Avni Eli Schwartz Thomas Zillinger Gunther Hartmann Antonella Di Pizio Neils Ben Quashie Rivka Dikstein Motti Gerlic Ana Claudia Torrecilhas Carmit Levy Esther N. M. Nolte-‘t Hoen Andrew G. Bowie Neta Regev-Rudzki
author_facet	Yifat Ofir-Birin Hila Ben Ami Pilo Abel Cruz Camacho Ariel Rudik Anna Rivkin Or-Yam Revach Netta Nir Tal Block Tamin Paula Abou Karam Edo Kiper Yoav Peleg Reinat Nevo Aryeh Solomon Tal Havkin-Solomon Alicia Rojas Ron Rotkopf Ziv Porat Dror Avni Eli Schwartz Thomas Zillinger Gunther Hartmann Antonella Di Pizio Neils Ben Quashie Rivka Dikstein Motti Gerlic Ana Claudia Torrecilhas Carmit Levy Esther N. M. Nolte-‘t Hoen Andrew G. Bowie Neta Regev-Rudzki
author_sort	Yifat Ofir-Birin
title	Malaria parasites both repress host CXCL10 and use it as a cue for growth acceleration
title_short	Malaria parasites both repress host CXCL10 and use it as a cue for growth acceleration
title_full	Malaria parasites both repress host CXCL10 and use it as a cue for growth acceleration
title_fullStr	Malaria parasites both repress host CXCL10 and use it as a cue for growth acceleration
title_full_unstemmed	Malaria parasites both repress host CXCL10 and use it as a cue for growth acceleration
title_sort	malaria parasites both repress host cxcl10 and use it as a cue for growth acceleration
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/224e6a94586f481d8f075fa74b8e8bf3
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Malaria parasites both repress host CXCL10 and use it as a cue for growth acceleration

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