Direct cysteine sulfenylation drives activation of the Src kinase

The activity of several protein kinases is increased upon cellular production of reactive oxygen species, which can cause cysteine oxidation. Here the authors show that sulfenylation of specific cysteine residues within Src induce local structural changes that directly impact its activation.

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Autores principales:	David E. Heppner, Christopher M. Dustin, Chenyi Liao, Milena Hristova, Carmen Veith, Andrew C. Little, Bethany A. Ahlers, Sheryl L. White, Bin Deng, Ying-Wai Lam, Jianing Li, Albert van der Vliet
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/224ec0c26833440495e8da4a22aecfde
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spelling	oai:doaj.org-article:224ec0c26833440495e8da4a22aecfde2021-12-02T15:33:59ZDirect cysteine sulfenylation drives activation of the Src kinase10.1038/s41467-018-06790-12041-1723https://doaj.org/article/224ec0c26833440495e8da4a22aecfde2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06790-1https://doaj.org/toc/2041-1723The activity of several protein kinases is increased upon cellular production of reactive oxygen species, which can cause cysteine oxidation. Here the authors show that sulfenylation of specific cysteine residues within Src induce local structural changes that directly impact its activation.David E. HeppnerChristopher M. DustinChenyi LiaoMilena HristovaCarmen VeithAndrew C. LittleBethany A. AhlersSheryl L. WhiteBin DengYing-Wai LamJianing LiAlbert van der VlietNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q David E. Heppner Christopher M. Dustin Chenyi Liao Milena Hristova Carmen Veith Andrew C. Little Bethany A. Ahlers Sheryl L. White Bin Deng Ying-Wai Lam Jianing Li Albert van der Vliet Direct cysteine sulfenylation drives activation of the Src kinase
description	The activity of several protein kinases is increased upon cellular production of reactive oxygen species, which can cause cysteine oxidation. Here the authors show that sulfenylation of specific cysteine residues within Src induce local structural changes that directly impact its activation.
format	article
author	David E. Heppner Christopher M. Dustin Chenyi Liao Milena Hristova Carmen Veith Andrew C. Little Bethany A. Ahlers Sheryl L. White Bin Deng Ying-Wai Lam Jianing Li Albert van der Vliet
author_facet	David E. Heppner Christopher M. Dustin Chenyi Liao Milena Hristova Carmen Veith Andrew C. Little Bethany A. Ahlers Sheryl L. White Bin Deng Ying-Wai Lam Jianing Li Albert van der Vliet
author_sort	David E. Heppner
title	Direct cysteine sulfenylation drives activation of the Src kinase
title_short	Direct cysteine sulfenylation drives activation of the Src kinase
title_full	Direct cysteine sulfenylation drives activation of the Src kinase
title_fullStr	Direct cysteine sulfenylation drives activation of the Src kinase
title_full_unstemmed	Direct cysteine sulfenylation drives activation of the Src kinase
title_sort	direct cysteine sulfenylation drives activation of the src kinase
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/224ec0c26833440495e8da4a22aecfde
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Direct cysteine sulfenylation drives activation of the Src kinase

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