Isoform specific differences in phospholipase C beta 1 expression in the prefrontal cortex in schizophrenia and suicide

Suicide risk: Pinpointing protein variants Variations in the expression of a specific protein may be linked to an increased risk of suicide in schizophrenia. The phospholipase C beta 1 (PLCB1) enzyme facilitates downstream signaling for multiple neurological systems, including dopamine regulation. M...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	M. Udawela, E. Scarr, S. Boer, J. Y. Um, A. J. Hannan, C. McOmish, C. C. Felder, E. A. Thomas, B. Dean
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Psychiatry RC435-571
Acceso en línea:	https://doaj.org/article/224f821bc93e4ba3b35f5142ed29b1f8
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:224f821bc93e4ba3b35f5142ed29b1f8
record_format	dspace
spelling	oai:doaj.org-article:224f821bc93e4ba3b35f5142ed29b1f82021-12-02T12:30:09ZIsoform specific differences in phospholipase C beta 1 expression in the prefrontal cortex in schizophrenia and suicide10.1038/s41537-017-0020-x2334-265Xhttps://doaj.org/article/224f821bc93e4ba3b35f5142ed29b1f82017-04-01T00:00:00Zhttps://doi.org/10.1038/s41537-017-0020-xhttps://doaj.org/toc/2334-265XSuicide risk: Pinpointing protein variants Variations in the expression of a specific protein may be linked to an increased risk of suicide in schizophrenia. The phospholipase C beta 1 (PLCB1) enzyme facilitates downstream signaling for multiple neurological systems, including dopamine regulation. Madhara Udewela at the Florey Institute, Australia, and co-workers measured post-mortem levels of two PLCB1 variants (a and b) in two areas of the prefrontal cortex (BA9 and BA46) in schizophrenia, many of whom were suicide completers. Levels of PLCB1a protein were lower in BA9 in patients with schizophrenia. In addition, PLCB1b protein levels were lower and PLCB1b RNA levels were higher in BA9 in those patients who died by suicide. However, these variations were not found in suicide victims who suffered from other mental health disorders. Changes in PLCB1 could provide a marker for suicide risk in schizophrenia.M. UdawelaE. ScarrS. BoerJ. Y. UmA. J. HannanC. McOmishC. C. FelderE. A. ThomasB. DeanNature PortfolioarticlePsychiatryRC435-571ENnpj Schizophrenia, Vol 3, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Psychiatry RC435-571
spellingShingle	Psychiatry RC435-571 M. Udawela E. Scarr S. Boer J. Y. Um A. J. Hannan C. McOmish C. C. Felder E. A. Thomas B. Dean Isoform specific differences in phospholipase C beta 1 expression in the prefrontal cortex in schizophrenia and suicide
description	Suicide risk: Pinpointing protein variants Variations in the expression of a specific protein may be linked to an increased risk of suicide in schizophrenia. The phospholipase C beta 1 (PLCB1) enzyme facilitates downstream signaling for multiple neurological systems, including dopamine regulation. Madhara Udewela at the Florey Institute, Australia, and co-workers measured post-mortem levels of two PLCB1 variants (a and b) in two areas of the prefrontal cortex (BA9 and BA46) in schizophrenia, many of whom were suicide completers. Levels of PLCB1a protein were lower in BA9 in patients with schizophrenia. In addition, PLCB1b protein levels were lower and PLCB1b RNA levels were higher in BA9 in those patients who died by suicide. However, these variations were not found in suicide victims who suffered from other mental health disorders. Changes in PLCB1 could provide a marker for suicide risk in schizophrenia.
format	article
author	M. Udawela E. Scarr S. Boer J. Y. Um A. J. Hannan C. McOmish C. C. Felder E. A. Thomas B. Dean
author_facet	M. Udawela E. Scarr S. Boer J. Y. Um A. J. Hannan C. McOmish C. C. Felder E. A. Thomas B. Dean
author_sort	M. Udawela
title	Isoform specific differences in phospholipase C beta 1 expression in the prefrontal cortex in schizophrenia and suicide
title_short	Isoform specific differences in phospholipase C beta 1 expression in the prefrontal cortex in schizophrenia and suicide
title_full	Isoform specific differences in phospholipase C beta 1 expression in the prefrontal cortex in schizophrenia and suicide
title_fullStr	Isoform specific differences in phospholipase C beta 1 expression in the prefrontal cortex in schizophrenia and suicide
title_full_unstemmed	Isoform specific differences in phospholipase C beta 1 expression in the prefrontal cortex in schizophrenia and suicide
title_sort	isoform specific differences in phospholipase c beta 1 expression in the prefrontal cortex in schizophrenia and suicide
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/224f821bc93e4ba3b35f5142ed29b1f8
work_keys_str_mv	AT mudawela isoformspecificdifferencesinphospholipasecbeta1expressionintheprefrontalcortexinschizophreniaandsuicide AT escarr isoformspecificdifferencesinphospholipasecbeta1expressionintheprefrontalcortexinschizophreniaandsuicide AT sboer isoformspecificdifferencesinphospholipasecbeta1expressionintheprefrontalcortexinschizophreniaandsuicide AT jyum isoformspecificdifferencesinphospholipasecbeta1expressionintheprefrontalcortexinschizophreniaandsuicide AT ajhannan isoformspecificdifferencesinphospholipasecbeta1expressionintheprefrontalcortexinschizophreniaandsuicide AT cmcomish isoformspecificdifferencesinphospholipasecbeta1expressionintheprefrontalcortexinschizophreniaandsuicide AT ccfelder isoformspecificdifferencesinphospholipasecbeta1expressionintheprefrontalcortexinschizophreniaandsuicide AT eathomas isoformspecificdifferencesinphospholipasecbeta1expressionintheprefrontalcortexinschizophreniaandsuicide AT bdean isoformspecificdifferencesinphospholipasecbeta1expressionintheprefrontalcortexinschizophreniaandsuicide
_version_	1718394384878141440

Isoform specific differences in phospholipase C beta 1 expression in the prefrontal cortex in schizophrenia and suicide

Ejemplares similares