Drug administration errors in hospital inpatients: a systematic review.

<h4>Context</h4>Drug administration in the hospital setting is the last barrier before a possible error reaches the patient.<h4>Objectives</h4>We aimed to analyze the prevalence and nature of administration error rate detected by the observation method.<h4>Data sources&...

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Autores principales:	Sarah Berdot, Florence Gillaizeau, Thibaut Caruba, Patrice Prognon, Pierre Durieux, Brigitte Sabatier
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2250334e06b74a4289648349cac82954
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spelling	oai:doaj.org-article:2250334e06b74a4289648349cac829542021-11-18T07:40:54ZDrug administration errors in hospital inpatients: a systematic review.1932-620310.1371/journal.pone.0068856https://doaj.org/article/2250334e06b74a4289648349cac829542013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23818992/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Context</h4>Drug administration in the hospital setting is the last barrier before a possible error reaches the patient.<h4>Objectives</h4>We aimed to analyze the prevalence and nature of administration error rate detected by the observation method.<h4>Data sources</h4>Embase, MEDLINE, Cochrane Library from 1966 to December 2011 and reference lists of included studies.<h4>Study selection</h4>Observational studies, cross-sectional studies, before-and-after studies, and randomized controlled trials that measured the rate of administration errors in inpatients were included.<h4>Data extraction</h4>Two reviewers (senior pharmacists) independently identified studies for inclusion. One reviewer extracted the data; the second reviewer checked the data. The main outcome was the error rate calculated as being the number of errors without wrong time errors divided by the Total Opportunity for Errors (TOE, sum of the total number of doses ordered plus the unordered doses given), and multiplied by 100. For studies that reported it, clinical impact was reclassified into four categories from fatal to minor or no impact. Due to a large heterogeneity, results were expressed as median values (interquartile range, IQR), according to their study design.<h4>Results</h4>Among 2088 studies, a total of 52 reported TOE. Most of the studies were cross-sectional studies (N=46). The median error rate without wrong time errors for the cross-sectional studies using TOE was 10.5% [IQR: 7.3%-21.7%]. No fatal error was observed and most errors were classified as minor in the 18 studies in which clinical impact was analyzed. We did not find any evidence of publication bias.<h4>Conclusions</h4>Administration errors are frequent among inpatients. The median error rate without wrong time errors for the cross-sectional studies using TOE was about 10%. A standardization of administration error rate using the same denominator (TOE), numerator and types of errors is essential for further publications.Sarah BerdotFlorence GillaizeauThibaut CarubaPatrice PrognonPierre DurieuxBrigitte SabatierPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 6, p e68856 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sarah Berdot Florence Gillaizeau Thibaut Caruba Patrice Prognon Pierre Durieux Brigitte Sabatier Drug administration errors in hospital inpatients: a systematic review.
description	<h4>Context</h4>Drug administration in the hospital setting is the last barrier before a possible error reaches the patient.<h4>Objectives</h4>We aimed to analyze the prevalence and nature of administration error rate detected by the observation method.<h4>Data sources</h4>Embase, MEDLINE, Cochrane Library from 1966 to December 2011 and reference lists of included studies.<h4>Study selection</h4>Observational studies, cross-sectional studies, before-and-after studies, and randomized controlled trials that measured the rate of administration errors in inpatients were included.<h4>Data extraction</h4>Two reviewers (senior pharmacists) independently identified studies for inclusion. One reviewer extracted the data; the second reviewer checked the data. The main outcome was the error rate calculated as being the number of errors without wrong time errors divided by the Total Opportunity for Errors (TOE, sum of the total number of doses ordered plus the unordered doses given), and multiplied by 100. For studies that reported it, clinical impact was reclassified into four categories from fatal to minor or no impact. Due to a large heterogeneity, results were expressed as median values (interquartile range, IQR), according to their study design.<h4>Results</h4>Among 2088 studies, a total of 52 reported TOE. Most of the studies were cross-sectional studies (N=46). The median error rate without wrong time errors for the cross-sectional studies using TOE was 10.5% [IQR: 7.3%-21.7%]. No fatal error was observed and most errors were classified as minor in the 18 studies in which clinical impact was analyzed. We did not find any evidence of publication bias.<h4>Conclusions</h4>Administration errors are frequent among inpatients. The median error rate without wrong time errors for the cross-sectional studies using TOE was about 10%. A standardization of administration error rate using the same denominator (TOE), numerator and types of errors is essential for further publications.
format	article
author	Sarah Berdot Florence Gillaizeau Thibaut Caruba Patrice Prognon Pierre Durieux Brigitte Sabatier
author_facet	Sarah Berdot Florence Gillaizeau Thibaut Caruba Patrice Prognon Pierre Durieux Brigitte Sabatier
author_sort	Sarah Berdot
title	Drug administration errors in hospital inpatients: a systematic review.
title_short	Drug administration errors in hospital inpatients: a systematic review.
title_full	Drug administration errors in hospital inpatients: a systematic review.
title_fullStr	Drug administration errors in hospital inpatients: a systematic review.
title_full_unstemmed	Drug administration errors in hospital inpatients: a systematic review.
title_sort	drug administration errors in hospital inpatients: a systematic review.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/2250334e06b74a4289648349cac82954
work_keys_str_mv	AT sarahberdot drugadministrationerrorsinhospitalinpatientsasystematicreview AT florencegillaizeau drugadministrationerrorsinhospitalinpatientsasystematicreview AT thibautcaruba drugadministrationerrorsinhospitalinpatientsasystematicreview AT patriceprognon drugadministrationerrorsinhospitalinpatientsasystematicreview AT pierredurieux drugadministrationerrorsinhospitalinpatientsasystematicreview AT brigittesabatier drugadministrationerrorsinhospitalinpatientsasystematicreview
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Drug administration errors in hospital inpatients: a systematic review.

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