EGFR/ARF6 regulation of Hh signalling stimulates oncogenic Ras tumour overgrowth

EGFR signalling is required for oncogenic Ras driven tumorigenesis. In this study, using aDrosophilatumour model the authors demonstrate that depletion of Arf6, a Ras-related GTP-binding protein activated by EGFR, supresses oncogenic Ras driven overgrowth via modulation of Hedgehog signalling.

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Autores principales:	Chiswili Chabu, Da-Ming Li, Tian Xu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/22505722246448f89a425539c5692e26
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spelling	oai:doaj.org-article:22505722246448f89a425539c5692e262021-12-02T14:42:28ZEGFR/ARF6 regulation of Hh signalling stimulates oncogenic Ras tumour overgrowth10.1038/ncomms146882041-1723https://doaj.org/article/22505722246448f89a425539c5692e262017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14688https://doaj.org/toc/2041-1723EGFR signalling is required for oncogenic Ras driven tumorigenesis. In this study, using aDrosophilatumour model the authors demonstrate that depletion of Arf6, a Ras-related GTP-binding protein activated by EGFR, supresses oncogenic Ras driven overgrowth via modulation of Hedgehog signalling.Chiswili ChabuDa-Ming LiTian XuNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chiswili Chabu Da-Ming Li Tian Xu EGFR/ARF6 regulation of Hh signalling stimulates oncogenic Ras tumour overgrowth
description	EGFR signalling is required for oncogenic Ras driven tumorigenesis. In this study, using aDrosophilatumour model the authors demonstrate that depletion of Arf6, a Ras-related GTP-binding protein activated by EGFR, supresses oncogenic Ras driven overgrowth via modulation of Hedgehog signalling.
format	article
author	Chiswili Chabu Da-Ming Li Tian Xu
author_facet	Chiswili Chabu Da-Ming Li Tian Xu
author_sort	Chiswili Chabu
title	EGFR/ARF6 regulation of Hh signalling stimulates oncogenic Ras tumour overgrowth
title_short	EGFR/ARF6 regulation of Hh signalling stimulates oncogenic Ras tumour overgrowth
title_full	EGFR/ARF6 regulation of Hh signalling stimulates oncogenic Ras tumour overgrowth
title_fullStr	EGFR/ARF6 regulation of Hh signalling stimulates oncogenic Ras tumour overgrowth
title_full_unstemmed	EGFR/ARF6 regulation of Hh signalling stimulates oncogenic Ras tumour overgrowth
title_sort	egfr/arf6 regulation of hh signalling stimulates oncogenic ras tumour overgrowth
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/22505722246448f89a425539c5692e26
work_keys_str_mv	AT chiswilichabu egfrarf6regulationofhhsignallingstimulatesoncogenicrastumourovergrowth AT damingli egfrarf6regulationofhhsignallingstimulatesoncogenicrastumourovergrowth AT tianxu egfrarf6regulationofhhsignallingstimulatesoncogenicrastumourovergrowth
_version_	1718389677942112256

EGFR/ARF6 regulation of Hh signalling stimulates oncogenic Ras tumour overgrowth

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