Adeno-associated virus capsid assembly is divergent and stochastic

Adeno-associated viruses (AAVs) have emerged as promising gene therapy vectors.The AAV capsid consists of 60 subunits made up from three distinct viral proteins (VPs). Here authors record high-resolution native mass spectra of intact AAV capsids to assess the VP stoichiometries in a panel of serotyp...

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Autores principales:	Tobias P. Wörner, Antonette Bennett, Sana Habka, Joost Snijder, Olga Friese, Thomas Powers, Mavis Agbandje-McKenna, Albert J. R. Heck
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/225246aa1453400ca051adc69a713cdf
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spelling	oai:doaj.org-article:225246aa1453400ca051adc69a713cdf2021-12-02T13:31:14ZAdeno-associated virus capsid assembly is divergent and stochastic10.1038/s41467-021-21935-52041-1723https://doaj.org/article/225246aa1453400ca051adc69a713cdf2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21935-5https://doaj.org/toc/2041-1723Adeno-associated viruses (AAVs) have emerged as promising gene therapy vectors.The AAV capsid consists of 60 subunits made up from three distinct viral proteins (VPs). Here authors record high-resolution native mass spectra of intact AAV capsids to assess the VP stoichiometries in a panel of serotypes and reveals an extremely heterogeneous population of capsids of variable composition.Tobias P. WörnerAntonette BennettSana HabkaJoost SnijderOlga FrieseThomas PowersMavis Agbandje-McKennaAlbert J. R. HeckNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tobias P. Wörner Antonette Bennett Sana Habka Joost Snijder Olga Friese Thomas Powers Mavis Agbandje-McKenna Albert J. R. Heck Adeno-associated virus capsid assembly is divergent and stochastic
description	Adeno-associated viruses (AAVs) have emerged as promising gene therapy vectors.The AAV capsid consists of 60 subunits made up from three distinct viral proteins (VPs). Here authors record high-resolution native mass spectra of intact AAV capsids to assess the VP stoichiometries in a panel of serotypes and reveals an extremely heterogeneous population of capsids of variable composition.
format	article
author	Tobias P. Wörner Antonette Bennett Sana Habka Joost Snijder Olga Friese Thomas Powers Mavis Agbandje-McKenna Albert J. R. Heck
author_facet	Tobias P. Wörner Antonette Bennett Sana Habka Joost Snijder Olga Friese Thomas Powers Mavis Agbandje-McKenna Albert J. R. Heck
author_sort	Tobias P. Wörner
title	Adeno-associated virus capsid assembly is divergent and stochastic
title_short	Adeno-associated virus capsid assembly is divergent and stochastic
title_full	Adeno-associated virus capsid assembly is divergent and stochastic
title_fullStr	Adeno-associated virus capsid assembly is divergent and stochastic
title_full_unstemmed	Adeno-associated virus capsid assembly is divergent and stochastic
title_sort	adeno-associated virus capsid assembly is divergent and stochastic
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/225246aa1453400ca051adc69a713cdf
work_keys_str_mv	AT tobiaspworner adenoassociatedviruscapsidassemblyisdivergentandstochastic AT antonettebennett adenoassociatedviruscapsidassemblyisdivergentandstochastic AT sanahabka adenoassociatedviruscapsidassemblyisdivergentandstochastic AT joostsnijder adenoassociatedviruscapsidassemblyisdivergentandstochastic AT olgafriese adenoassociatedviruscapsidassemblyisdivergentandstochastic AT thomaspowers adenoassociatedviruscapsidassemblyisdivergentandstochastic AT mavisagbandjemckenna adenoassociatedviruscapsidassemblyisdivergentandstochastic AT albertjrheck adenoassociatedviruscapsidassemblyisdivergentandstochastic
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Adeno-associated virus capsid assembly is divergent and stochastic

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