Emergence and Spread of Carbapenem-Resistant and Aminoglycoside-Panresistant <italic toggle="yes">Enterobacter cloacae</italic> Complex Isolates Coproducing NDM-Type Metallo-β-Lactamase and 16S rRNA Methylase in Myanmar

ABSTRACT Surveillance of 10 hospitals and a regional public health laboratory in Myanmar identified 31 isolates of carbapenem-resistant Enterobacter cloacae complex harboring blaNDM-type. Of these isolates, 19 were highly resistant to aminoglycosides and harbored one or more genes encoding 16S rRNA...

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Autores principales:	Satoshi Oshiro, Tatsuya Tada, Shin Watanabe, Mari Tohya, Tomomi Hishinuma, Hiroki Uchida, Kyoko Kuwahara-Arai, San Mya, Khin Nyein Zan, Teruo Kirikae, Htay Htay Tin
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2020
Materias:	NDM-type metallo-β-lactamase 16S rRNA methylase Enterobacter cloacae complex Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/22531456c6ea47308078911bc2783d6b
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spelling	oai:doaj.org-article:22531456c6ea47308078911bc2783d6b2021-11-15T15:29:17ZEmergence and Spread of Carbapenem-Resistant and Aminoglycoside-Panresistant <italic toggle="yes">Enterobacter cloacae</italic> Complex Isolates Coproducing NDM-Type Metallo-β-Lactamase and 16S rRNA Methylase in Myanmar10.1128/mSphere.00054-202379-5042https://doaj.org/article/22531456c6ea47308078911bc2783d6b2020-04-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSphere.00054-20https://doaj.org/toc/2379-5042ABSTRACT Surveillance of 10 hospitals and a regional public health laboratory in Myanmar identified 31 isolates of carbapenem-resistant Enterobacter cloacae complex harboring blaNDM-type. Of these isolates, 19 were highly resistant to aminoglycosides and harbored one or more genes encoding 16S rRNA methylases, including armA, rmtB, rmtC, and/or rmtE. Of the 19 isolates, 16 were Enterobacter xiangfangensis ST200, with armA on the chromosome and a plasmid harboring blaNDM-1 and rmtC, indicating that these isolates were clonally disseminated nationwide in Myanmar. IMPORTANCE The emergence of multidrug-resistant E. cloacae complex has become a public health threat worldwide. E. xiangfangensis is a recently classified species belonging to E. cloacae complex. Here, we report a clonal dissemination of multidrug-resistant E. xiangfangensis ST200 producing two types of New Delhi metallo-β-lactamase (NDM-type MBL), NDM-1 and -4, and three types of 16S rRNA methylases, ArmA, RmtC, and RmtE, in hospitals in Myanmar. The observation of these multidrug-resistant E. xiangfangensis ST200 isolates stresses the urgency to continue molecular epidemiological surveillance of these pathogens in Myanmar and in South Asian countries.Satoshi OshiroTatsuya TadaShin WatanabeMari TohyaTomomi HishinumaHiroki UchidaKyoko Kuwahara-AraiSan MyaKhin Nyein ZanTeruo KirikaeHtay Htay TinAmerican Society for MicrobiologyarticleNDM-type metallo-β-lactamase16S rRNA methylaseEnterobacter cloacae complexMicrobiologyQR1-502ENmSphere, Vol 5, Iss 2 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	NDM-type metallo-β-lactamase 16S rRNA methylase Enterobacter cloacae complex Microbiology QR1-502
spellingShingle	NDM-type metallo-β-lactamase 16S rRNA methylase Enterobacter cloacae complex Microbiology QR1-502 Satoshi Oshiro Tatsuya Tada Shin Watanabe Mari Tohya Tomomi Hishinuma Hiroki Uchida Kyoko Kuwahara-Arai San Mya Khin Nyein Zan Teruo Kirikae Htay Htay Tin Emergence and Spread of Carbapenem-Resistant and Aminoglycoside-Panresistant <italic toggle="yes">Enterobacter cloacae</italic> Complex Isolates Coproducing NDM-Type Metallo-β-Lactamase and 16S rRNA Methylase in Myanmar
description	ABSTRACT Surveillance of 10 hospitals and a regional public health laboratory in Myanmar identified 31 isolates of carbapenem-resistant Enterobacter cloacae complex harboring blaNDM-type. Of these isolates, 19 were highly resistant to aminoglycosides and harbored one or more genes encoding 16S rRNA methylases, including armA, rmtB, rmtC, and/or rmtE. Of the 19 isolates, 16 were Enterobacter xiangfangensis ST200, with armA on the chromosome and a plasmid harboring blaNDM-1 and rmtC, indicating that these isolates were clonally disseminated nationwide in Myanmar. IMPORTANCE The emergence of multidrug-resistant E. cloacae complex has become a public health threat worldwide. E. xiangfangensis is a recently classified species belonging to E. cloacae complex. Here, we report a clonal dissemination of multidrug-resistant E. xiangfangensis ST200 producing two types of New Delhi metallo-β-lactamase (NDM-type MBL), NDM-1 and -4, and three types of 16S rRNA methylases, ArmA, RmtC, and RmtE, in hospitals in Myanmar. The observation of these multidrug-resistant E. xiangfangensis ST200 isolates stresses the urgency to continue molecular epidemiological surveillance of these pathogens in Myanmar and in South Asian countries.
format	article
author	Satoshi Oshiro Tatsuya Tada Shin Watanabe Mari Tohya Tomomi Hishinuma Hiroki Uchida Kyoko Kuwahara-Arai San Mya Khin Nyein Zan Teruo Kirikae Htay Htay Tin
author_facet	Satoshi Oshiro Tatsuya Tada Shin Watanabe Mari Tohya Tomomi Hishinuma Hiroki Uchida Kyoko Kuwahara-Arai San Mya Khin Nyein Zan Teruo Kirikae Htay Htay Tin
author_sort	Satoshi Oshiro
title	Emergence and Spread of Carbapenem-Resistant and Aminoglycoside-Panresistant <italic toggle="yes">Enterobacter cloacae</italic> Complex Isolates Coproducing NDM-Type Metallo-β-Lactamase and 16S rRNA Methylase in Myanmar
title_short	Emergence and Spread of Carbapenem-Resistant and Aminoglycoside-Panresistant <italic toggle="yes">Enterobacter cloacae</italic> Complex Isolates Coproducing NDM-Type Metallo-β-Lactamase and 16S rRNA Methylase in Myanmar
title_full	Emergence and Spread of Carbapenem-Resistant and Aminoglycoside-Panresistant <italic toggle="yes">Enterobacter cloacae</italic> Complex Isolates Coproducing NDM-Type Metallo-β-Lactamase and 16S rRNA Methylase in Myanmar
title_fullStr	Emergence and Spread of Carbapenem-Resistant and Aminoglycoside-Panresistant <italic toggle="yes">Enterobacter cloacae</italic> Complex Isolates Coproducing NDM-Type Metallo-β-Lactamase and 16S rRNA Methylase in Myanmar
title_full_unstemmed	Emergence and Spread of Carbapenem-Resistant and Aminoglycoside-Panresistant <italic toggle="yes">Enterobacter cloacae</italic> Complex Isolates Coproducing NDM-Type Metallo-β-Lactamase and 16S rRNA Methylase in Myanmar
title_sort	emergence and spread of carbapenem-resistant and aminoglycoside-panresistant <italic toggle="yes">enterobacter cloacae</italic> complex isolates coproducing ndm-type metallo-β-lactamase and 16s rrna methylase in myanmar
publisher	American Society for Microbiology
publishDate	2020
url	https://doaj.org/article/22531456c6ea47308078911bc2783d6b
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Emergence and Spread of Carbapenem-Resistant and Aminoglycoside-Panresistant <italic toggle="yes">Enterobacter cloacae</italic> Complex Isolates Coproducing NDM-Type Metallo-β-Lactamase and 16S rRNA Methylase in Myanmar

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