Linking the metabolic syndrome and obesity with vitamin D status: risks and opportunities for improving cardiometabolic health and well-being

Meis Moukayed,1 William B Grant21School of Arts and Sciences, American University in Dubai, Dubai, UAE; 2Sunlight, Nutrition, and Health Research Center, San Francisco, CA 94164-1603, USACorrespondence: William B GrantSunlight, Nutrition, and Health Research Center, P.O. Box 641603, San Francisco, C...

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Autores principales:	Moukayed M, Grant WB
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	vitamin D vitamin D deficiency prevention metabolic syndrome obesity adipose tissue cardiovascular disease risk reduction noncommunicable diseases Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/22559d8b1f7c4d3f823586eae6bb0d33
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spelling	oai:doaj.org-article:22559d8b1f7c4d3f823586eae6bb0d332021-12-02T10:46:25ZLinking the metabolic syndrome and obesity with vitamin D status: risks and opportunities for improving cardiometabolic health and well-being1178-7007https://doaj.org/article/22559d8b1f7c4d3f823586eae6bb0d332019-08-01T00:00:00Zhttps://www.dovepress.com/linking-the-metabolic-syndrome-and-obesity-with-vitamin-d-status-risks-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Meis Moukayed,1 William B Grant21School of Arts and Sciences, American University in Dubai, Dubai, UAE; 2Sunlight, Nutrition, and Health Research Center, San Francisco, CA 94164-1603, USACorrespondence: William B GrantSunlight, Nutrition, and Health Research Center, P.O. Box 641603, San Francisco, CA 94164-1603, USAEmail wbgrant@infionline.netAbstract: The global death toll from noncommunicable diseases is exceptionally high, reported to cause 71% of global deaths worldwide. Metabolic syndrome risk factors, especially excessive adiposity and obesity, are at the heart of the problem resulting in increased co-morbidities such as cardiometabolic diseases and cancer, increased health costs, poorer quality of life, and shortened survival. Vitamin D3 can positively reverse many of these adverse effects and outcomes through blocking signaling mechanisms that predispose to cardiometabolic and metastatic disease. As an affordable natural agent, vitamin D3 can be used to counteract obesity-induced inflammation, block early adipogenesis, enhance glucose uptake, counteract hyperleptinemia, ameliorate insulin resistance, and reduce hypertension. This is supported by data from in vitro, in vivo and epidemiological studies and clinical trials. We propose that everyone in general and obese patients in particular consider raising 25-hydroxyvitamin D levels through UVB exposure and/or supplemental vitamin D3 intake to reduce cardiometabolic and metastatic disease and increase longevity.Keywords: vitamin D, metabolic syndrome, obesity, adipose tissue, cardiovascular disease, risk reductionMoukayed MGrant WBDove Medical Pressarticlevitamin Dvitamin D deficiencypreventionmetabolic syndromeobesityadipose tissuecardiovascular diseaserisk reductionnoncommunicable diseasesSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 12, Pp 1437-1447 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	vitamin D vitamin D deficiency prevention metabolic syndrome obesity adipose tissue cardiovascular disease risk reduction noncommunicable diseases Specialties of internal medicine RC581-951
spellingShingle	vitamin D vitamin D deficiency prevention metabolic syndrome obesity adipose tissue cardiovascular disease risk reduction noncommunicable diseases Specialties of internal medicine RC581-951 Moukayed M Grant WB Linking the metabolic syndrome and obesity with vitamin D status: risks and opportunities for improving cardiometabolic health and well-being
description	Meis Moukayed,1 William B Grant21School of Arts and Sciences, American University in Dubai, Dubai, UAE; 2Sunlight, Nutrition, and Health Research Center, San Francisco, CA 94164-1603, USACorrespondence: William B GrantSunlight, Nutrition, and Health Research Center, P.O. Box 641603, San Francisco, CA 94164-1603, USAEmail wbgrant@infionline.netAbstract: The global death toll from noncommunicable diseases is exceptionally high, reported to cause 71% of global deaths worldwide. Metabolic syndrome risk factors, especially excessive adiposity and obesity, are at the heart of the problem resulting in increased co-morbidities such as cardiometabolic diseases and cancer, increased health costs, poorer quality of life, and shortened survival. Vitamin D3 can positively reverse many of these adverse effects and outcomes through blocking signaling mechanisms that predispose to cardiometabolic and metastatic disease. As an affordable natural agent, vitamin D3 can be used to counteract obesity-induced inflammation, block early adipogenesis, enhance glucose uptake, counteract hyperleptinemia, ameliorate insulin resistance, and reduce hypertension. This is supported by data from in vitro, in vivo and epidemiological studies and clinical trials. We propose that everyone in general and obese patients in particular consider raising 25-hydroxyvitamin D levels through UVB exposure and/or supplemental vitamin D3 intake to reduce cardiometabolic and metastatic disease and increase longevity.Keywords: vitamin D, metabolic syndrome, obesity, adipose tissue, cardiovascular disease, risk reduction
format	article
author	Moukayed M Grant WB
author_facet	Moukayed M Grant WB
author_sort	Moukayed M
title	Linking the metabolic syndrome and obesity with vitamin D status: risks and opportunities for improving cardiometabolic health and well-being
title_short	Linking the metabolic syndrome and obesity with vitamin D status: risks and opportunities for improving cardiometabolic health and well-being
title_full	Linking the metabolic syndrome and obesity with vitamin D status: risks and opportunities for improving cardiometabolic health and well-being
title_fullStr	Linking the metabolic syndrome and obesity with vitamin D status: risks and opportunities for improving cardiometabolic health and well-being
title_full_unstemmed	Linking the metabolic syndrome and obesity with vitamin D status: risks and opportunities for improving cardiometabolic health and well-being
title_sort	linking the metabolic syndrome and obesity with vitamin d status: risks and opportunities for improving cardiometabolic health and well-being
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/22559d8b1f7c4d3f823586eae6bb0d33
work_keys_str_mv	AT moukayedm linkingthemetabolicsyndromeandobesitywithvitamindstatusrisksandopportunitiesforimprovingcardiometabolichealthandwellbeing AT grantwb linkingthemetabolicsyndromeandobesitywithvitamindstatusrisksandopportunitiesforimprovingcardiometabolichealthandwellbeing
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Linking the metabolic syndrome and obesity with vitamin D status: risks and opportunities for improving cardiometabolic health and well-being

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