In children allergic to ragweed pollen, nasal inflammation is not influenced by monosensitization or polysensitization

Matteo Gelardi,1 Mariangela Bosoni,2 Marco Morelli,2 Silvia Beretta,2 Cristoforo Incorvaia,3 Serena Buttafava,4 Massimo Landi,5 Simonetta Masieri,6 Franco Frati,4 Nicola Quaranta,1 Gian Vincenzo Zuccotti21Otolaryngology Section, Department of Neuroscience and Sensory Organs, University of Bari, 2Dep...

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Autores principales:	Gelardi M, Bosoni M, Morelli M, Beretta S, Incorvaia C, Buttafava S, Landi M, Masieri S, Frati F, Quaranta N, Zuccotti GV
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	allergic rhinitis polysensitization nasal inflammation nasal cytology ragweed pollen grass pollen. Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/22571fb2f1054bb5a8ec07cfc2d6cf56
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spelling	oai:doaj.org-article:22571fb2f1054bb5a8ec07cfc2d6cf562021-12-02T05:09:50ZIn children allergic to ragweed pollen, nasal inflammation is not influenced by monosensitization or polysensitization1178-7031https://doaj.org/article/22571fb2f1054bb5a8ec07cfc2d6cf562016-04-01T00:00:00Zhttps://www.dovepress.com/in-children-allergic-to-ragweed-pollen-nasal-inflammation-is-not-influ-peer-reviewed-article-JIRhttps://doaj.org/toc/1178-7031Matteo Gelardi,1 Mariangela Bosoni,2 Marco Morelli,2 Silvia Beretta,2 Cristoforo Incorvaia,3 Serena Buttafava,4 Massimo Landi,5 Simonetta Masieri,6 Franco Frati,4 Nicola Quaranta,1 Gian Vincenzo Zuccotti21Otolaryngology Section, Department of Neuroscience and Sensory Organs, University of Bari, 2Department of Pediatrics, Luigi Sacco Hospital, University of Milan, 3Allergy/Pulmonary Rehabilitation Unit, ICP Hospital, 4Medical and Scientific Department, Stallergenes Italy, Milan, 5Department of Pediatrics, ASL TO1, Turin, 6Department of Otorhinolaryngology, Sapienza University of Rome, Rome, ItalyBackground: In patients polysensitized to pollen allergens, the priming effect, by which the sensitivity of the nasal mucosa to an allergen is increased by the previous exposure to another allergen, is a known phenomenon. This study was aimed at evaluating the degree of nasal inflammation, assessed by nasal cytology, in children with allergic rhinitis (AR) from ragweed pollen according to being monosensitized or polysensitized.Methods: The study included 47 children. Of them, 24 suffered from AR caused by sensitization to grass pollen and ragweed pollen (group A) and 23 were sensitized only to ragweed pollen (group B). In all patients, the severity of AR was assessed according to the Allergic Rhinitis and Its Impact on Asthma guidelines, and comorbidities were also evaluated.Results: In group A, 16.7% of children had a mild intermittent AR, 4.2% a moderate-to-severe intermittent, 33.3% a mild persistent, and 45.8% a moderate-to-severe persistent; in group B, 26.1% of children had a mild intermittent AR, 0% a moderate-to-severe intermittent, 52.2% a mild persistent, and 21.7% a moderate-to-severe persistent. No significant difference was detected in the number of the considered comorbidities between the two groups. The cell counts of neutrophils, eosinophils, lymphocytes/plasma cells, and mast cells were high but not significantly different in the two groups.Conclusion: These findings show that the degree of nasal inflammation found in children with ragweed-induced AR is not influenced by additional allergy to grass pollen and confirm the previously reported absence of priming effect in ragweed allergy.Keywords: allergic rhinitis, pollen sensitization, priming effect, nasal cytology, eosinophils, neutrophilsGelardi MBosoni MMorelli MBeretta SIncorvaia CButtafava SLandi MMasieri SFrati FQuaranta NZuccotti GVDove Medical Pressarticleallergic rhinitispolysensitizationnasal inflammationnasal cytologyragweed pollengrass pollen.PathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol 2016, Iss Issue 1, Pp 21-25 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	allergic rhinitis polysensitization nasal inflammation nasal cytology ragweed pollen grass pollen. Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	allergic rhinitis polysensitization nasal inflammation nasal cytology ragweed pollen grass pollen. Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Gelardi M Bosoni M Morelli M Beretta S Incorvaia C Buttafava S Landi M Masieri S Frati F Quaranta N Zuccotti GV In children allergic to ragweed pollen, nasal inflammation is not influenced by monosensitization or polysensitization
description	Matteo Gelardi,1 Mariangela Bosoni,2 Marco Morelli,2 Silvia Beretta,2 Cristoforo Incorvaia,3 Serena Buttafava,4 Massimo Landi,5 Simonetta Masieri,6 Franco Frati,4 Nicola Quaranta,1 Gian Vincenzo Zuccotti21Otolaryngology Section, Department of Neuroscience and Sensory Organs, University of Bari, 2Department of Pediatrics, Luigi Sacco Hospital, University of Milan, 3Allergy/Pulmonary Rehabilitation Unit, ICP Hospital, 4Medical and Scientific Department, Stallergenes Italy, Milan, 5Department of Pediatrics, ASL TO1, Turin, 6Department of Otorhinolaryngology, Sapienza University of Rome, Rome, ItalyBackground: In patients polysensitized to pollen allergens, the priming effect, by which the sensitivity of the nasal mucosa to an allergen is increased by the previous exposure to another allergen, is a known phenomenon. This study was aimed at evaluating the degree of nasal inflammation, assessed by nasal cytology, in children with allergic rhinitis (AR) from ragweed pollen according to being monosensitized or polysensitized.Methods: The study included 47 children. Of them, 24 suffered from AR caused by sensitization to grass pollen and ragweed pollen (group A) and 23 were sensitized only to ragweed pollen (group B). In all patients, the severity of AR was assessed according to the Allergic Rhinitis and Its Impact on Asthma guidelines, and comorbidities were also evaluated.Results: In group A, 16.7% of children had a mild intermittent AR, 4.2% a moderate-to-severe intermittent, 33.3% a mild persistent, and 45.8% a moderate-to-severe persistent; in group B, 26.1% of children had a mild intermittent AR, 0% a moderate-to-severe intermittent, 52.2% a mild persistent, and 21.7% a moderate-to-severe persistent. No significant difference was detected in the number of the considered comorbidities between the two groups. The cell counts of neutrophils, eosinophils, lymphocytes/plasma cells, and mast cells were high but not significantly different in the two groups.Conclusion: These findings show that the degree of nasal inflammation found in children with ragweed-induced AR is not influenced by additional allergy to grass pollen and confirm the previously reported absence of priming effect in ragweed allergy.Keywords: allergic rhinitis, pollen sensitization, priming effect, nasal cytology, eosinophils, neutrophils
format	article
author	Gelardi M Bosoni M Morelli M Beretta S Incorvaia C Buttafava S Landi M Masieri S Frati F Quaranta N Zuccotti GV
author_facet	Gelardi M Bosoni M Morelli M Beretta S Incorvaia C Buttafava S Landi M Masieri S Frati F Quaranta N Zuccotti GV
author_sort	Gelardi M
title	In children allergic to ragweed pollen, nasal inflammation is not influenced by monosensitization or polysensitization
title_short	In children allergic to ragweed pollen, nasal inflammation is not influenced by monosensitization or polysensitization
title_full	In children allergic to ragweed pollen, nasal inflammation is not influenced by monosensitization or polysensitization
title_fullStr	In children allergic to ragweed pollen, nasal inflammation is not influenced by monosensitization or polysensitization
title_full_unstemmed	In children allergic to ragweed pollen, nasal inflammation is not influenced by monosensitization or polysensitization
title_sort	in children allergic to ragweed pollen, nasal inflammation is not influenced by monosensitization or polysensitization
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/22571fb2f1054bb5a8ec07cfc2d6cf56
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In children allergic to ragweed pollen, nasal inflammation is not influenced by monosensitization or polysensitization

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