Wounding triggers MIRO-1 dependent mitochondrial fragmentation that accelerates epidermal wound closure through oxidative signaling

Mitochondria are important organelles that generate and respond to signals to maintain cellular homeostasis. Here the authors show that wounding triggers GTPase MIRO-1- and calcium-dependent mitochondrial fragmentation, which aids tissue wound repair through cytochrome P450 and mitochondrial reactiv...

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Autores principales: Hongying Fu, Hengda Zhou, Xinghai Yu, Jingxiu Xu, Jinghua Zhou, Xinan Meng, Jianzhi Zhao, Yu Zhou, Andrew D. Chisholm, Suhong Xu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/2257f5fe94b74eefb78548a5646635fb
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Sumario:Mitochondria are important organelles that generate and respond to signals to maintain cellular homeostasis. Here the authors show that wounding triggers GTPase MIRO-1- and calcium-dependent mitochondrial fragmentation, which aids tissue wound repair through cytochrome P450 and mitochondrial reactive oxygen species.