Wounding triggers MIRO-1 dependent mitochondrial fragmentation that accelerates epidermal wound closure through oxidative signaling

Mitochondria are important organelles that generate and respond to signals to maintain cellular homeostasis. Here the authors show that wounding triggers GTPase MIRO-1- and calcium-dependent mitochondrial fragmentation, which aids tissue wound repair through cytochrome P450 and mitochondrial reactiv...

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Autores principales:	Hongying Fu, Hengda Zhou, Xinghai Yu, Jingxiu Xu, Jinghua Zhou, Xinan Meng, Jianzhi Zhao, Yu Zhou, Andrew D. Chisholm, Suhong Xu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2257f5fe94b74eefb78548a5646635fb
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spelling	oai:doaj.org-article:2257f5fe94b74eefb78548a5646635fb2021-12-02T15:39:15ZWounding triggers MIRO-1 dependent mitochondrial fragmentation that accelerates epidermal wound closure through oxidative signaling10.1038/s41467-020-14885-x2041-1723https://doaj.org/article/2257f5fe94b74eefb78548a5646635fb2020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14885-xhttps://doaj.org/toc/2041-1723Mitochondria are important organelles that generate and respond to signals to maintain cellular homeostasis. Here the authors show that wounding triggers GTPase MIRO-1- and calcium-dependent mitochondrial fragmentation, which aids tissue wound repair through cytochrome P450 and mitochondrial reactive oxygen species.Hongying FuHengda ZhouXinghai YuJingxiu XuJinghua ZhouXinan MengJianzhi ZhaoYu ZhouAndrew D. ChisholmSuhong XuNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hongying Fu Hengda Zhou Xinghai Yu Jingxiu Xu Jinghua Zhou Xinan Meng Jianzhi Zhao Yu Zhou Andrew D. Chisholm Suhong Xu Wounding triggers MIRO-1 dependent mitochondrial fragmentation that accelerates epidermal wound closure through oxidative signaling
description	Mitochondria are important organelles that generate and respond to signals to maintain cellular homeostasis. Here the authors show that wounding triggers GTPase MIRO-1- and calcium-dependent mitochondrial fragmentation, which aids tissue wound repair through cytochrome P450 and mitochondrial reactive oxygen species.
format	article
author	Hongying Fu Hengda Zhou Xinghai Yu Jingxiu Xu Jinghua Zhou Xinan Meng Jianzhi Zhao Yu Zhou Andrew D. Chisholm Suhong Xu
author_facet	Hongying Fu Hengda Zhou Xinghai Yu Jingxiu Xu Jinghua Zhou Xinan Meng Jianzhi Zhao Yu Zhou Andrew D. Chisholm Suhong Xu
author_sort	Hongying Fu
title	Wounding triggers MIRO-1 dependent mitochondrial fragmentation that accelerates epidermal wound closure through oxidative signaling
title_short	Wounding triggers MIRO-1 dependent mitochondrial fragmentation that accelerates epidermal wound closure through oxidative signaling
title_full	Wounding triggers MIRO-1 dependent mitochondrial fragmentation that accelerates epidermal wound closure through oxidative signaling
title_fullStr	Wounding triggers MIRO-1 dependent mitochondrial fragmentation that accelerates epidermal wound closure through oxidative signaling
title_full_unstemmed	Wounding triggers MIRO-1 dependent mitochondrial fragmentation that accelerates epidermal wound closure through oxidative signaling
title_sort	wounding triggers miro-1 dependent mitochondrial fragmentation that accelerates epidermal wound closure through oxidative signaling
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/2257f5fe94b74eefb78548a5646635fb
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Wounding triggers MIRO-1 dependent mitochondrial fragmentation that accelerates epidermal wound closure through oxidative signaling

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