Fungus Causing White-Nose Syndrome in Bats Accumulates Genetic Variability in North America with No Sign of Recombination

ABSTRACT Emerging fungal diseases of wildlife are on the rise worldwide, and the white-nose syndrome (WNS) epidemic in North American bats is a catastrophic example. The causal agent of WNS is a single clone of the fungus Pseudogymnoascus destructans. Early evolutionary change in this clonal populat...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jigar Trivedi, Josianne Lachapelle, Karen J. Vanderwolf, Vikram Misra, Craig K. R. Willis, John M. Ratcliffe, Rob W. Ness, James B. Anderson, Linda M. Kohn
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2017
Materias:	clonal reproduction epidemic fungal pathogens population biology population genomics spontaneous mutations Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/2258666ba31846ce8ff5019d3965a060
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2258666ba31846ce8ff5019d3965a060
record_format	dspace
spelling	oai:doaj.org-article:2258666ba31846ce8ff5019d3965a0602021-11-15T15:22:05ZFungus Causing White-Nose Syndrome in Bats Accumulates Genetic Variability in North America with No Sign of Recombination10.1128/mSphereDirect.00271-172379-5042https://doaj.org/article/2258666ba31846ce8ff5019d3965a0602017-08-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSphereDirect.00271-17https://doaj.org/toc/2379-5042ABSTRACT Emerging fungal diseases of wildlife are on the rise worldwide, and the white-nose syndrome (WNS) epidemic in North American bats is a catastrophic example. The causal agent of WNS is a single clone of the fungus Pseudogymnoascus destructans. Early evolutionary change in this clonal population has major implications for disease ecology and conservation. Accumulation of variation in the fungus through mutation, and shuffling of variation through recombination, could affect the virulence and transmissibility of the fungus and the durability of what appears to be resistance arising in some bat populations. Our genome-wide analysis shows that the clonal population of P. destructans has expanded in size from a single genotype, has begun to accumulate variation through mutation, and presents no evidence as yet of genetic exchange among individuals. IMPORTANCE Since its discovery in 2006, the emerging infectious disease known as white-nose syndrome has killed millions of bats in North America, making it one of the most devastating wildlife epidemics in recorded history. We demonstrate that there has been as yet only spontaneous mutation across the North American population of P. destructans, and we find no indication of recombination. Thus, selective forces, which might otherwise impact pathogenic virulence, have so far had essentially no genetic variation on which to act. Our study confirmed the time of origin for the first and, thus far, only introduction of P. destructans to North America. This system provides an unprecedented opportunity to follow the evolution of a host-pathogen interaction unfolding in real time.Jigar TrivediJosianne LachapelleKaren J. VanderwolfVikram MisraCraig K. R. WillisJohn M. RatcliffeRob W. NessJames B. AndersonLinda M. KohnAmerican Society for Microbiologyarticleclonal reproductionepidemicfungal pathogenspopulation biologypopulation genomicsspontaneous mutationsMicrobiologyQR1-502ENmSphere, Vol 2, Iss 4 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	clonal reproduction epidemic fungal pathogens population biology population genomics spontaneous mutations Microbiology QR1-502
spellingShingle	clonal reproduction epidemic fungal pathogens population biology population genomics spontaneous mutations Microbiology QR1-502 Jigar Trivedi Josianne Lachapelle Karen J. Vanderwolf Vikram Misra Craig K. R. Willis John M. Ratcliffe Rob W. Ness James B. Anderson Linda M. Kohn Fungus Causing White-Nose Syndrome in Bats Accumulates Genetic Variability in North America with No Sign of Recombination
description	ABSTRACT Emerging fungal diseases of wildlife are on the rise worldwide, and the white-nose syndrome (WNS) epidemic in North American bats is a catastrophic example. The causal agent of WNS is a single clone of the fungus Pseudogymnoascus destructans. Early evolutionary change in this clonal population has major implications for disease ecology and conservation. Accumulation of variation in the fungus through mutation, and shuffling of variation through recombination, could affect the virulence and transmissibility of the fungus and the durability of what appears to be resistance arising in some bat populations. Our genome-wide analysis shows that the clonal population of P. destructans has expanded in size from a single genotype, has begun to accumulate variation through mutation, and presents no evidence as yet of genetic exchange among individuals. IMPORTANCE Since its discovery in 2006, the emerging infectious disease known as white-nose syndrome has killed millions of bats in North America, making it one of the most devastating wildlife epidemics in recorded history. We demonstrate that there has been as yet only spontaneous mutation across the North American population of P. destructans, and we find no indication of recombination. Thus, selective forces, which might otherwise impact pathogenic virulence, have so far had essentially no genetic variation on which to act. Our study confirmed the time of origin for the first and, thus far, only introduction of P. destructans to North America. This system provides an unprecedented opportunity to follow the evolution of a host-pathogen interaction unfolding in real time.
format	article
author	Jigar Trivedi Josianne Lachapelle Karen J. Vanderwolf Vikram Misra Craig K. R. Willis John M. Ratcliffe Rob W. Ness James B. Anderson Linda M. Kohn
author_facet	Jigar Trivedi Josianne Lachapelle Karen J. Vanderwolf Vikram Misra Craig K. R. Willis John M. Ratcliffe Rob W. Ness James B. Anderson Linda M. Kohn
author_sort	Jigar Trivedi
title	Fungus Causing White-Nose Syndrome in Bats Accumulates Genetic Variability in North America with No Sign of Recombination
title_short	Fungus Causing White-Nose Syndrome in Bats Accumulates Genetic Variability in North America with No Sign of Recombination
title_full	Fungus Causing White-Nose Syndrome in Bats Accumulates Genetic Variability in North America with No Sign of Recombination
title_fullStr	Fungus Causing White-Nose Syndrome in Bats Accumulates Genetic Variability in North America with No Sign of Recombination
title_full_unstemmed	Fungus Causing White-Nose Syndrome in Bats Accumulates Genetic Variability in North America with No Sign of Recombination
title_sort	fungus causing white-nose syndrome in bats accumulates genetic variability in north america with no sign of recombination
publisher	American Society for Microbiology
publishDate	2017
url	https://doaj.org/article/2258666ba31846ce8ff5019d3965a060
work_keys_str_mv	AT jigartrivedi funguscausingwhitenosesyndromeinbatsaccumulatesgeneticvariabilityinnorthamericawithnosignofrecombination AT josiannelachapelle funguscausingwhitenosesyndromeinbatsaccumulatesgeneticvariabilityinnorthamericawithnosignofrecombination AT karenjvanderwolf funguscausingwhitenosesyndromeinbatsaccumulatesgeneticvariabilityinnorthamericawithnosignofrecombination AT vikrammisra funguscausingwhitenosesyndromeinbatsaccumulatesgeneticvariabilityinnorthamericawithnosignofrecombination AT craigkrwillis funguscausingwhitenosesyndromeinbatsaccumulatesgeneticvariabilityinnorthamericawithnosignofrecombination AT johnmratcliffe funguscausingwhitenosesyndromeinbatsaccumulatesgeneticvariabilityinnorthamericawithnosignofrecombination AT robwness funguscausingwhitenosesyndromeinbatsaccumulatesgeneticvariabilityinnorthamericawithnosignofrecombination AT jamesbanderson funguscausingwhitenosesyndromeinbatsaccumulatesgeneticvariabilityinnorthamericawithnosignofrecombination AT lindamkohn funguscausingwhitenosesyndromeinbatsaccumulatesgeneticvariabilityinnorthamericawithnosignofrecombination
_version_	1718428057948127232

Fungus Causing White-Nose Syndrome in Bats Accumulates Genetic Variability in North America with No Sign of Recombination

Ejemplares similares