Immune-profiling of ZIKV-infected patients identifies a distinct function of plasmacytoid dendritic cells for immune cross-regulation

Zika virus (ZIKV) poses a significant public health threat, but the immune landscape changes following ZIKV infection is still unclear. Here, the authors show, using flow cytometry and transcriptomic data, that ZIKV induces a multitude of immune responses, with plasmacytoid dendritic cells poised ce...

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Autores principales:	Xiaoming Sun, Stephane Hua, Ce Gao, Jane E. Blackmer, Zhengyu Ouyang, Kevin Ard, Andrea Ciaranello, Sigal Yawetz, Paul E. Sax, Eric S. Rosenberg, Mathias Lichterfeld, Xu G. Yu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/22635906b94d4ef385dfa69cc1d812bc
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spelling	oai:doaj.org-article:22635906b94d4ef385dfa69cc1d812bc2021-12-02T15:42:58ZImmune-profiling of ZIKV-infected patients identifies a distinct function of plasmacytoid dendritic cells for immune cross-regulation10.1038/s41467-020-16217-52041-1723https://doaj.org/article/22635906b94d4ef385dfa69cc1d812bc2020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16217-5https://doaj.org/toc/2041-1723Zika virus (ZIKV) poses a significant public health threat, but the immune landscape changes following ZIKV infection is still unclear. Here, the authors show, using flow cytometry and transcriptomic data, that ZIKV induces a multitude of immune responses, with plasmacytoid dendritic cells poised centrally to interact with other immune cell types.Xiaoming SunStephane HuaCe GaoJane E. BlackmerZhengyu OuyangKevin ArdAndrea CiaranelloSigal YawetzPaul E. SaxEric S. RosenbergMathias LichterfeldXu G. YuNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiaoming Sun Stephane Hua Ce Gao Jane E. Blackmer Zhengyu Ouyang Kevin Ard Andrea Ciaranello Sigal Yawetz Paul E. Sax Eric S. Rosenberg Mathias Lichterfeld Xu G. Yu Immune-profiling of ZIKV-infected patients identifies a distinct function of plasmacytoid dendritic cells for immune cross-regulation
description	Zika virus (ZIKV) poses a significant public health threat, but the immune landscape changes following ZIKV infection is still unclear. Here, the authors show, using flow cytometry and transcriptomic data, that ZIKV induces a multitude of immune responses, with plasmacytoid dendritic cells poised centrally to interact with other immune cell types.
format	article
author	Xiaoming Sun Stephane Hua Ce Gao Jane E. Blackmer Zhengyu Ouyang Kevin Ard Andrea Ciaranello Sigal Yawetz Paul E. Sax Eric S. Rosenberg Mathias Lichterfeld Xu G. Yu
author_facet	Xiaoming Sun Stephane Hua Ce Gao Jane E. Blackmer Zhengyu Ouyang Kevin Ard Andrea Ciaranello Sigal Yawetz Paul E. Sax Eric S. Rosenberg Mathias Lichterfeld Xu G. Yu
author_sort	Xiaoming Sun
title	Immune-profiling of ZIKV-infected patients identifies a distinct function of plasmacytoid dendritic cells for immune cross-regulation
title_short	Immune-profiling of ZIKV-infected patients identifies a distinct function of plasmacytoid dendritic cells for immune cross-regulation
title_full	Immune-profiling of ZIKV-infected patients identifies a distinct function of plasmacytoid dendritic cells for immune cross-regulation
title_fullStr	Immune-profiling of ZIKV-infected patients identifies a distinct function of plasmacytoid dendritic cells for immune cross-regulation
title_full_unstemmed	Immune-profiling of ZIKV-infected patients identifies a distinct function of plasmacytoid dendritic cells for immune cross-regulation
title_sort	immune-profiling of zikv-infected patients identifies a distinct function of plasmacytoid dendritic cells for immune cross-regulation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/22635906b94d4ef385dfa69cc1d812bc
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Immune-profiling of ZIKV-infected patients identifies a distinct function of plasmacytoid dendritic cells for immune cross-regulation

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