Increase in polymorphonuclear myeloid-derived suppressor cells and regulatory T-cells in children with B-cell acute lymphoblastic leukemia

Abstract Our study aimed to evaluate the levels of MDSCs and Tregs in pediatric B-cell acute lymphoblastic leukemia (B-ALL), their relation to patients’ clinical and laboratory features, and the impact of these cells on the induction response. This study included 31 pediatric B-ALL patients and 27 h...

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Autores principales:	Asmaa M. Zahran, Azza Shibl, Amal Rayan, Mohamed Alaa Eldeen Hassan Mohamed, Amira M. M. Osman, Khaled Saad, Khaled Hashim Mahmoud, Aliaa M. A. Ghandour, Khalid I. Elsayh, Omnia El-Badawy
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/22637e1834364003a4dee865fcc7aa34
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spelling	oai:doaj.org-article:22637e1834364003a4dee865fcc7aa342021-12-02T16:26:23ZIncrease in polymorphonuclear myeloid-derived suppressor cells and regulatory T-cells in children with B-cell acute lymphoblastic leukemia10.1038/s41598-021-94469-x2045-2322https://doaj.org/article/22637e1834364003a4dee865fcc7aa342021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94469-xhttps://doaj.org/toc/2045-2322Abstract Our study aimed to evaluate the levels of MDSCs and Tregs in pediatric B-cell acute lymphoblastic leukemia (B-ALL), their relation to patients’ clinical and laboratory features, and the impact of these cells on the induction response. This study included 31 pediatric B-ALL patients and 27 healthy controls. All patients were treated according to the protocols of the modified St. Jude Children’s Research Hospital total therapy study XIIIB for ALL. Levels of MDSCs and Tregs were analyzed using flow cytometry. We observed a reduction in the levels of CD4 + T-cells and an increase in both the polymorphonuclear MDSCs (PMN-MDSCs) and Tregs. The frequencies of PMN-MDSCs and Tregs were directly related to the levels of peripheral and bone marrow blast cells and CD34 + cells. Complete postinduction remission was associated with reduced percentages of PMN-MDSCs and Tregs, with the level of PMN-MDCs in this subpopulation approaching that of healthy controls. PMN-MDSCs and Tregs jointly play a critical role in maintaining an immune-suppressive state suitable for B-ALL tumor progression. Thereby, they could be independent predictors of B-ALL progress, and finely targeting both PMN-MDSCs and Tregs may be a promising approach for the treatment of B-ALL.Asmaa M. ZahranAzza ShiblAmal RayanMohamed Alaa Eldeen Hassan MohamedAmira M. M. OsmanKhaled SaadKhaled Hashim MahmoudAliaa M. A. GhandourKhalid I. ElsayhOmnia El-BadawyNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Asmaa M. Zahran Azza Shibl Amal Rayan Mohamed Alaa Eldeen Hassan Mohamed Amira M. M. Osman Khaled Saad Khaled Hashim Mahmoud Aliaa M. A. Ghandour Khalid I. Elsayh Omnia El-Badawy Increase in polymorphonuclear myeloid-derived suppressor cells and regulatory T-cells in children with B-cell acute lymphoblastic leukemia
description	Abstract Our study aimed to evaluate the levels of MDSCs and Tregs in pediatric B-cell acute lymphoblastic leukemia (B-ALL), their relation to patients’ clinical and laboratory features, and the impact of these cells on the induction response. This study included 31 pediatric B-ALL patients and 27 healthy controls. All patients were treated according to the protocols of the modified St. Jude Children’s Research Hospital total therapy study XIIIB for ALL. Levels of MDSCs and Tregs were analyzed using flow cytometry. We observed a reduction in the levels of CD4 + T-cells and an increase in both the polymorphonuclear MDSCs (PMN-MDSCs) and Tregs. The frequencies of PMN-MDSCs and Tregs were directly related to the levels of peripheral and bone marrow blast cells and CD34 + cells. Complete postinduction remission was associated with reduced percentages of PMN-MDSCs and Tregs, with the level of PMN-MDCs in this subpopulation approaching that of healthy controls. PMN-MDSCs and Tregs jointly play a critical role in maintaining an immune-suppressive state suitable for B-ALL tumor progression. Thereby, they could be independent predictors of B-ALL progress, and finely targeting both PMN-MDSCs and Tregs may be a promising approach for the treatment of B-ALL.
format	article
author	Asmaa M. Zahran Azza Shibl Amal Rayan Mohamed Alaa Eldeen Hassan Mohamed Amira M. M. Osman Khaled Saad Khaled Hashim Mahmoud Aliaa M. A. Ghandour Khalid I. Elsayh Omnia El-Badawy
author_facet	Asmaa M. Zahran Azza Shibl Amal Rayan Mohamed Alaa Eldeen Hassan Mohamed Amira M. M. Osman Khaled Saad Khaled Hashim Mahmoud Aliaa M. A. Ghandour Khalid I. Elsayh Omnia El-Badawy
author_sort	Asmaa M. Zahran
title	Increase in polymorphonuclear myeloid-derived suppressor cells and regulatory T-cells in children with B-cell acute lymphoblastic leukemia
title_short	Increase in polymorphonuclear myeloid-derived suppressor cells and regulatory T-cells in children with B-cell acute lymphoblastic leukemia
title_full	Increase in polymorphonuclear myeloid-derived suppressor cells and regulatory T-cells in children with B-cell acute lymphoblastic leukemia
title_fullStr	Increase in polymorphonuclear myeloid-derived suppressor cells and regulatory T-cells in children with B-cell acute lymphoblastic leukemia
title_full_unstemmed	Increase in polymorphonuclear myeloid-derived suppressor cells and regulatory T-cells in children with B-cell acute lymphoblastic leukemia
title_sort	increase in polymorphonuclear myeloid-derived suppressor cells and regulatory t-cells in children with b-cell acute lymphoblastic leukemia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/22637e1834364003a4dee865fcc7aa34
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Increase in polymorphonuclear myeloid-derived suppressor cells and regulatory T-cells in children with B-cell acute lymphoblastic leukemia

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