Toxoplasma LIPIN is essential in channeling host lipid fluxes through membrane biogenesis and lipid storage

Apicomplexa generate essential lipids as combination of host fatty acids and de novo synthesized within the apicoplast. Here, the authors identify a phosphatidic acid phosphatase in Toxoplasma gondii, TgLIPIN, as central for controlled lipid synthesis and define the host-scavenged lipidome.

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Autores principales:	Sheena Dass, Serena Shunmugam, Laurence Berry, Christophe-Sebastien Arnold, Nicholas J. Katris, Samuel Duley, Fabien Pierrel, Marie-France Cesbron-Delauw, Yoshiki Yamaryo-Botté, Cyrille Y. Botté
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/226664588bd840de98c6c9d52b6e4025
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spelling	oai:doaj.org-article:226664588bd840de98c6c9d52b6e40252021-12-02T14:58:43ZToxoplasma LIPIN is essential in channeling host lipid fluxes through membrane biogenesis and lipid storage10.1038/s41467-021-22956-w2041-1723https://doaj.org/article/226664588bd840de98c6c9d52b6e40252021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22956-whttps://doaj.org/toc/2041-1723Apicomplexa generate essential lipids as combination of host fatty acids and de novo synthesized within the apicoplast. Here, the authors identify a phosphatidic acid phosphatase in Toxoplasma gondii, TgLIPIN, as central for controlled lipid synthesis and define the host-scavenged lipidome.Sheena DassSerena ShunmugamLaurence BerryChristophe-Sebastien ArnoldNicholas J. KatrisSamuel DuleyFabien PierrelMarie-France Cesbron-DelauwYoshiki Yamaryo-BottéCyrille Y. BottéNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sheena Dass Serena Shunmugam Laurence Berry Christophe-Sebastien Arnold Nicholas J. Katris Samuel Duley Fabien Pierrel Marie-France Cesbron-Delauw Yoshiki Yamaryo-Botté Cyrille Y. Botté Toxoplasma LIPIN is essential in channeling host lipid fluxes through membrane biogenesis and lipid storage
description	Apicomplexa generate essential lipids as combination of host fatty acids and de novo synthesized within the apicoplast. Here, the authors identify a phosphatidic acid phosphatase in Toxoplasma gondii, TgLIPIN, as central for controlled lipid synthesis and define the host-scavenged lipidome.
format	article
author	Sheena Dass Serena Shunmugam Laurence Berry Christophe-Sebastien Arnold Nicholas J. Katris Samuel Duley Fabien Pierrel Marie-France Cesbron-Delauw Yoshiki Yamaryo-Botté Cyrille Y. Botté
author_facet	Sheena Dass Serena Shunmugam Laurence Berry Christophe-Sebastien Arnold Nicholas J. Katris Samuel Duley Fabien Pierrel Marie-France Cesbron-Delauw Yoshiki Yamaryo-Botté Cyrille Y. Botté
author_sort	Sheena Dass
title	Toxoplasma LIPIN is essential in channeling host lipid fluxes through membrane biogenesis and lipid storage
title_short	Toxoplasma LIPIN is essential in channeling host lipid fluxes through membrane biogenesis and lipid storage
title_full	Toxoplasma LIPIN is essential in channeling host lipid fluxes through membrane biogenesis and lipid storage
title_fullStr	Toxoplasma LIPIN is essential in channeling host lipid fluxes through membrane biogenesis and lipid storage
title_full_unstemmed	Toxoplasma LIPIN is essential in channeling host lipid fluxes through membrane biogenesis and lipid storage
title_sort	toxoplasma lipin is essential in channeling host lipid fluxes through membrane biogenesis and lipid storage
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/226664588bd840de98c6c9d52b6e4025
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Toxoplasma LIPIN is essential in channeling host lipid fluxes through membrane biogenesis and lipid storage

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