Spatial Navigation and Visuospatial Strategies in Typical and Atypical Aging

Age-related spatial navigation decline is more pronounced in patients with mild cognitive impairment (MCI) and Alzheimer’s disease (AD) dementia. We used a realistic-looking virtual navigation test suite to analyze different aspects of visuospatial processing in typical and atypical aging. A total o...

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Autores principales:	Martina Laczó, Jan M. Wiener, Jana Kalinova, Veronika Matuskova, Martin Vyhnalek, Jakub Hort, Jan Laczó
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	mild cognitive impairment Alzheimer’s disease spatial navigation route learning wayfinding perspective taking Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/226695d8bee7423f8e07dd7d8bd1157a
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id	oai:doaj.org-article:226695d8bee7423f8e07dd7d8bd1157a
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spelling	oai:doaj.org-article:226695d8bee7423f8e07dd7d8bd1157a2021-11-25T16:56:54ZSpatial Navigation and Visuospatial Strategies in Typical and Atypical Aging10.3390/brainsci111114212076-3425https://doaj.org/article/226695d8bee7423f8e07dd7d8bd1157a2021-10-01T00:00:00Zhttps://www.mdpi.com/2076-3425/11/11/1421https://doaj.org/toc/2076-3425Age-related spatial navigation decline is more pronounced in patients with mild cognitive impairment (MCI) and Alzheimer’s disease (AD) dementia. We used a realistic-looking virtual navigation test suite to analyze different aspects of visuospatial processing in typical and atypical aging. A total of 219 older adults were recruited from the Czech Brain Aging Study cohort. Cognitively normal older adults (CN; <i>n</i> = 78), patients with amnestic MCI (<i>n</i> = 75), and those with mild AD dementia (<i>n</i> = 66) underwent three navigational tasks, cognitive assessment, and brain MRI. Route learning and wayfinding/perspective-taking tasks distinguished the groups as performance and learning declined and specific visuospatial strategies were less utilized with increasing cognitive impairment. Increased perspective shift and utilization of non-specific strategies were associated with worse task performance across the groups. Primacy and recency effects were observed across the groups in the route learning and the wayfinding/perspective-taking task, respectively. In addition, a primacy effect was present in the wayfinding/perspective-taking task in the CN older adults. More effective spatial navigation was associated with better memory and executive functions. The results demonstrate that a realistic and ecologically valid spatial navigation test suite can reveal different aspects of visuospatial processing in typical and atypical aging.Martina LaczóJan M. WienerJana KalinovaVeronika MatuskovaMartin VyhnalekJakub HortJan LaczóMDPI AGarticlemild cognitive impairmentAlzheimer’s diseasespatial navigationroute learningwayfindingperspective takingNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENBrain Sciences, Vol 11, Iss 1421, p 1421 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	mild cognitive impairment Alzheimer’s disease spatial navigation route learning wayfinding perspective taking Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	mild cognitive impairment Alzheimer’s disease spatial navigation route learning wayfinding perspective taking Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Martina Laczó Jan M. Wiener Jana Kalinova Veronika Matuskova Martin Vyhnalek Jakub Hort Jan Laczó Spatial Navigation and Visuospatial Strategies in Typical and Atypical Aging
description	Age-related spatial navigation decline is more pronounced in patients with mild cognitive impairment (MCI) and Alzheimer’s disease (AD) dementia. We used a realistic-looking virtual navigation test suite to analyze different aspects of visuospatial processing in typical and atypical aging. A total of 219 older adults were recruited from the Czech Brain Aging Study cohort. Cognitively normal older adults (CN; <i>n</i> = 78), patients with amnestic MCI (<i>n</i> = 75), and those with mild AD dementia (<i>n</i> = 66) underwent three navigational tasks, cognitive assessment, and brain MRI. Route learning and wayfinding/perspective-taking tasks distinguished the groups as performance and learning declined and specific visuospatial strategies were less utilized with increasing cognitive impairment. Increased perspective shift and utilization of non-specific strategies were associated with worse task performance across the groups. Primacy and recency effects were observed across the groups in the route learning and the wayfinding/perspective-taking task, respectively. In addition, a primacy effect was present in the wayfinding/perspective-taking task in the CN older adults. More effective spatial navigation was associated with better memory and executive functions. The results demonstrate that a realistic and ecologically valid spatial navigation test suite can reveal different aspects of visuospatial processing in typical and atypical aging.
format	article
author	Martina Laczó Jan M. Wiener Jana Kalinova Veronika Matuskova Martin Vyhnalek Jakub Hort Jan Laczó
author_facet	Martina Laczó Jan M. Wiener Jana Kalinova Veronika Matuskova Martin Vyhnalek Jakub Hort Jan Laczó
author_sort	Martina Laczó
title	Spatial Navigation and Visuospatial Strategies in Typical and Atypical Aging
title_short	Spatial Navigation and Visuospatial Strategies in Typical and Atypical Aging
title_full	Spatial Navigation and Visuospatial Strategies in Typical and Atypical Aging
title_fullStr	Spatial Navigation and Visuospatial Strategies in Typical and Atypical Aging
title_full_unstemmed	Spatial Navigation and Visuospatial Strategies in Typical and Atypical Aging
title_sort	spatial navigation and visuospatial strategies in typical and atypical aging
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/226695d8bee7423f8e07dd7d8bd1157a
work_keys_str_mv	AT martinalaczo spatialnavigationandvisuospatialstrategiesintypicalandatypicalaging AT janmwiener spatialnavigationandvisuospatialstrategiesintypicalandatypicalaging AT janakalinova spatialnavigationandvisuospatialstrategiesintypicalandatypicalaging AT veronikamatuskova spatialnavigationandvisuospatialstrategiesintypicalandatypicalaging AT martinvyhnalek spatialnavigationandvisuospatialstrategiesintypicalandatypicalaging AT jakubhort spatialnavigationandvisuospatialstrategiesintypicalandatypicalaging AT janlaczo spatialnavigationandvisuospatialstrategiesintypicalandatypicalaging
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Spatial Navigation and Visuospatial Strategies in Typical and Atypical Aging

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