Glycan recognition in globally dominant human rotaviruses

Human rotaviruses (RV) bind to histo-blood group antigens (HBGA) for attachment, but how different viral genotypes interact with HBGA isn’t known. Here, Hu et al. report crystal structures of a prevalent and a neonate-specific RV in complex with HBGA and provide insights into glycan recognition and...

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Autores principales:	Liya Hu, Banumathi Sankaran, Daniel R. Laucirica, Ketki Patil, Wilhelm Salmen, Allan Chris M Ferreon, Phoebe S. Tsoi, Yi Lasanajak, David F. Smith, Sasirekha Ramani, Robert L. Atmar, Mary K. Estes, Josephine C. Ferreon, B. V. Venkataram Prasad
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/226e37b8d4144a7d953870719068de7d
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spelling	oai:doaj.org-article:226e37b8d4144a7d953870719068de7d2021-12-02T16:49:56ZGlycan recognition in globally dominant human rotaviruses10.1038/s41467-018-05098-42041-1723https://doaj.org/article/226e37b8d4144a7d953870719068de7d2018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05098-4https://doaj.org/toc/2041-1723Human rotaviruses (RV) bind to histo-blood group antigens (HBGA) for attachment, but how different viral genotypes interact with HBGA isn’t known. Here, Hu et al. report crystal structures of a prevalent and a neonate-specific RV in complex with HBGA and provide insights into glycan recognition and age-restricted tropism of RVs.Liya HuBanumathi SankaranDaniel R. LauciricaKetki PatilWilhelm SalmenAllan Chris M FerreonPhoebe S. TsoiYi LasanajakDavid F. SmithSasirekha RamaniRobert L. AtmarMary K. EstesJosephine C. FerreonB. V. Venkataram PrasadNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Liya Hu Banumathi Sankaran Daniel R. Laucirica Ketki Patil Wilhelm Salmen Allan Chris M Ferreon Phoebe S. Tsoi Yi Lasanajak David F. Smith Sasirekha Ramani Robert L. Atmar Mary K. Estes Josephine C. Ferreon B. V. Venkataram Prasad Glycan recognition in globally dominant human rotaviruses
description	Human rotaviruses (RV) bind to histo-blood group antigens (HBGA) for attachment, but how different viral genotypes interact with HBGA isn’t known. Here, Hu et al. report crystal structures of a prevalent and a neonate-specific RV in complex with HBGA and provide insights into glycan recognition and age-restricted tropism of RVs.
format	article
author	Liya Hu Banumathi Sankaran Daniel R. Laucirica Ketki Patil Wilhelm Salmen Allan Chris M Ferreon Phoebe S. Tsoi Yi Lasanajak David F. Smith Sasirekha Ramani Robert L. Atmar Mary K. Estes Josephine C. Ferreon B. V. Venkataram Prasad
author_facet	Liya Hu Banumathi Sankaran Daniel R. Laucirica Ketki Patil Wilhelm Salmen Allan Chris M Ferreon Phoebe S. Tsoi Yi Lasanajak David F. Smith Sasirekha Ramani Robert L. Atmar Mary K. Estes Josephine C. Ferreon B. V. Venkataram Prasad
author_sort	Liya Hu
title	Glycan recognition in globally dominant human rotaviruses
title_short	Glycan recognition in globally dominant human rotaviruses
title_full	Glycan recognition in globally dominant human rotaviruses
title_fullStr	Glycan recognition in globally dominant human rotaviruses
title_full_unstemmed	Glycan recognition in globally dominant human rotaviruses
title_sort	glycan recognition in globally dominant human rotaviruses
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/226e37b8d4144a7d953870719068de7d
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Glycan recognition in globally dominant human rotaviruses

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