Anticomplement therapy

Anticomplement therapy

Prathit A Kulkarni1, Vahid Afshar-Kharghan21Baylor College of Medicine, Houston, Texas, USA; 2The University of Texas, M.D. Anderson Cancer Center, Houston, Texas, USAAbstract: The complement system is an important part of innate immunity; however, as with other parts of the immune system, the compl...

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Autores principales: Prathit A Kulkarni, Vahid Afshar-Kharghan
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2009
Materias:
Medicine (General)
R5-920
Acceso en línea:https://doaj.org/article/2270e7b75e2d4967945be6dff192830e
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spelling oai:doaj.org-article:2270e7b75e2d4967945be6dff192830e2021-12-02T01:07:34ZAnticomplement therapy1177-54751177-5491https://doaj.org/article/2270e7b75e2d4967945be6dff192830e2009-02-01T00:00:00Zhttp://www.dovepress.com/anticomplement-therapy-a2863https://doaj.org/toc/1177-5475https://doaj.org/toc/1177-5491Prathit A Kulkarni1, Vahid Afshar-Kharghan21Baylor College of Medicine, Houston, Texas, USA; 2The University of Texas, M.D. Anderson Cancer Center, Houston, Texas, USAAbstract: The complement system is an important part of innate immunity; however, as with other parts of the immune system, the complement system can become pathologically activated and create or worsen disease. Anticomplement reagents have been studied for several years, but only recently have they emerged as a viable therapeutic tool. Here, we describe the role of the complement system in a wide array of diseases, as well as the use of anticomplement therapy as treatment for these diseases in animal models and in human clinical trials. Specifically, we will discuss the role of anticomplement therapy in paroxysmal nocturnal hemoglobinuria, glomerulonephritis, and heart disease, including coronary artery disease, myocardial infarction, and coronary revascularization procedures such as percutaneous coronary angioplasty and coronary artery bypass graft surgery.Keywords: complement, paroxysmal nocturnal hemoglobinuria, glomerulonephritis, myocardial infarction, cardiopulmonary bypass Prathit A KulkarniVahid Afshar-KharghanDove Medical PressarticleMedicine (General)R5-920ENBiologics: Targets & Therapy, Vol 2008, Iss Issue 4, Pp 671-685 (2009)
institution DOAJ
collection DOAJ
language EN
topic Medicine (General)
R5-920
spellingShingle Medicine (General)
R5-920
Prathit A Kulkarni
Vahid Afshar-Kharghan
Anticomplement therapy
description Prathit A Kulkarni1, Vahid Afshar-Kharghan21Baylor College of Medicine, Houston, Texas, USA; 2The University of Texas, M.D. Anderson Cancer Center, Houston, Texas, USAAbstract: The complement system is an important part of innate immunity; however, as with other parts of the immune system, the complement system can become pathologically activated and create or worsen disease. Anticomplement reagents have been studied for several years, but only recently have they emerged as a viable therapeutic tool. Here, we describe the role of the complement system in a wide array of diseases, as well as the use of anticomplement therapy as treatment for these diseases in animal models and in human clinical trials. Specifically, we will discuss the role of anticomplement therapy in paroxysmal nocturnal hemoglobinuria, glomerulonephritis, and heart disease, including coronary artery disease, myocardial infarction, and coronary revascularization procedures such as percutaneous coronary angioplasty and coronary artery bypass graft surgery.Keywords: complement, paroxysmal nocturnal hemoglobinuria, glomerulonephritis, myocardial infarction, cardiopulmonary bypass
format article
author Prathit A Kulkarni
Vahid Afshar-Kharghan
author_facet Prathit A Kulkarni
Vahid Afshar-Kharghan
author_sort Prathit A Kulkarni
title Anticomplement therapy
title_short Anticomplement therapy
title_full Anticomplement therapy
title_fullStr Anticomplement therapy
title_full_unstemmed Anticomplement therapy
title_sort anticomplement therapy
publisher Dove Medical Press
publishDate 2009
url https://doaj.org/article/2270e7b75e2d4967945be6dff192830e
work_keys_str_mv AT prathitakulkarni anticomplementtherapy
AT vahidafsharkharghan anticomplementtherapy
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