Nuclear Import of HIV-1

The delivery of the HIV-1 genome into the nucleus is an indispensable step in retroviral infection of non-dividing cells, but the mechanism of HIV-1 nuclear import has been a longstanding debate due to controversial experimental evidence. It was commonly believed that the HIV-1 capsid would need to...

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Autores principales:	Qi Shen, Chunxiang Wu, Christian Freniere, Therese N. Tripler, Yong Xiong
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	HIV-1 core capsid nuclear import reverse transcription uncoating nuclear pore complex Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/22794b4332f540ca981914c0430fa18f
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spelling	oai:doaj.org-article:22794b4332f540ca981914c0430fa18f2021-11-25T19:13:42ZNuclear Import of HIV-110.3390/v131122421999-4915https://doaj.org/article/22794b4332f540ca981914c0430fa18f2021-11-01T00:00:00Zhttps://www.mdpi.com/1999-4915/13/11/2242https://doaj.org/toc/1999-4915The delivery of the HIV-1 genome into the nucleus is an indispensable step in retroviral infection of non-dividing cells, but the mechanism of HIV-1 nuclear import has been a longstanding debate due to controversial experimental evidence. It was commonly believed that the HIV-1 capsid would need to disassemble (uncoat) in the cytosol before nuclear import because the capsid is larger than the central channel of nuclear pore complexes (NPCs); however, increasing evidence demonstrates that intact, or nearly intact, HIV-1 capsid passes through the NPC to enter the nucleus. With the protection of the capsid, the HIV-1 core completes reverse transcription in the nucleus and is translocated to the integration site. Uncoating occurs while, or after, the viral genome is released near the integration site. These independent discoveries reveal a compelling new paradigm of this important step of the HIV-1 life cycle. In this review, we summarize the recent studies related to HIV-1 nuclear import, highlighting the spatial–temporal relationship between the nuclear entry of the virus core, reverse transcription, and capsid uncoating.Qi ShenChunxiang WuChristian FreniereTherese N. TriplerYong XiongMDPI AGarticleHIV-1 corecapsidnuclear importreverse transcriptionuncoatingnuclear pore complexMicrobiologyQR1-502ENViruses, Vol 13, Iss 2242, p 2242 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	HIV-1 core capsid nuclear import reverse transcription uncoating nuclear pore complex Microbiology QR1-502
spellingShingle	HIV-1 core capsid nuclear import reverse transcription uncoating nuclear pore complex Microbiology QR1-502 Qi Shen Chunxiang Wu Christian Freniere Therese N. Tripler Yong Xiong Nuclear Import of HIV-1
description	The delivery of the HIV-1 genome into the nucleus is an indispensable step in retroviral infection of non-dividing cells, but the mechanism of HIV-1 nuclear import has been a longstanding debate due to controversial experimental evidence. It was commonly believed that the HIV-1 capsid would need to disassemble (uncoat) in the cytosol before nuclear import because the capsid is larger than the central channel of nuclear pore complexes (NPCs); however, increasing evidence demonstrates that intact, or nearly intact, HIV-1 capsid passes through the NPC to enter the nucleus. With the protection of the capsid, the HIV-1 core completes reverse transcription in the nucleus and is translocated to the integration site. Uncoating occurs while, or after, the viral genome is released near the integration site. These independent discoveries reveal a compelling new paradigm of this important step of the HIV-1 life cycle. In this review, we summarize the recent studies related to HIV-1 nuclear import, highlighting the spatial–temporal relationship between the nuclear entry of the virus core, reverse transcription, and capsid uncoating.
format	article
author	Qi Shen Chunxiang Wu Christian Freniere Therese N. Tripler Yong Xiong
author_facet	Qi Shen Chunxiang Wu Christian Freniere Therese N. Tripler Yong Xiong
author_sort	Qi Shen
title	Nuclear Import of HIV-1
title_short	Nuclear Import of HIV-1
title_full	Nuclear Import of HIV-1
title_fullStr	Nuclear Import of HIV-1
title_full_unstemmed	Nuclear Import of HIV-1
title_sort	nuclear import of hiv-1
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/22794b4332f540ca981914c0430fa18f
work_keys_str_mv	AT qishen nuclearimportofhiv1 AT chunxiangwu nuclearimportofhiv1 AT christianfreniere nuclearimportofhiv1 AT theresentripler nuclearimportofhiv1 AT yongxiong nuclearimportofhiv1
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Nuclear Import of HIV-1

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