Heterogeneity of mesenchymal stem cells in cartilage regeneration: from characterization to application

Abstract Articular cartilage is susceptible to damage but hard to self-repair due to its avascular nature. Traditional treatment methods are not able to produce satisfactory effects. Mesenchymal stem cells (MSCs) have shown great promise in cartilage repair. However, the therapeutic effect of MSCs i...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Kangkang Zha, Xu Li, Zhen Yang, Guangzhao Tian, Zhiqiang Sun, Xiang Sui, Yongjing Dai, Shuyun Liu, Quanyi Guo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R
Acceso en línea:	https://doaj.org/article/227d50a74b184d3abd2338a08d74e8a3
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:227d50a74b184d3abd2338a08d74e8a3
record_format	dspace
spelling	oai:doaj.org-article:227d50a74b184d3abd2338a08d74e8a32021-12-02T14:25:40ZHeterogeneity of mesenchymal stem cells in cartilage regeneration: from characterization to application10.1038/s41536-021-00122-62057-3995https://doaj.org/article/227d50a74b184d3abd2338a08d74e8a32021-03-01T00:00:00Zhttps://doi.org/10.1038/s41536-021-00122-6https://doaj.org/toc/2057-3995Abstract Articular cartilage is susceptible to damage but hard to self-repair due to its avascular nature. Traditional treatment methods are not able to produce satisfactory effects. Mesenchymal stem cells (MSCs) have shown great promise in cartilage repair. However, the therapeutic effect of MSCs is often unstable partly due to their heterogeneity. Understanding the heterogeneity of MSCs and the potential of different types of MSCs for cartilage regeneration will facilitate the selection of superior MSCs for treating cartilage damage. This review provides an overview of the heterogeneity of MSCs at the donor, tissue source and cell immunophenotype levels, including their cytological properties, such as their ability for proliferation, chondrogenic differentiation and immunoregulation, as well as their current applications in cartilage regeneration. This information will improve the precision of MSC-based therapeutic strategies, thus maximizing the efficiency of articular cartilage repair.Kangkang ZhaXu LiZhen YangGuangzhao TianZhiqiang SunXiang SuiYongjing DaiShuyun LiuQuanyi GuoNature PortfolioarticleMedicineRENnpj Regenerative Medicine, Vol 6, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R
spellingShingle	Medicine R Kangkang Zha Xu Li Zhen Yang Guangzhao Tian Zhiqiang Sun Xiang Sui Yongjing Dai Shuyun Liu Quanyi Guo Heterogeneity of mesenchymal stem cells in cartilage regeneration: from characterization to application
description	Abstract Articular cartilage is susceptible to damage but hard to self-repair due to its avascular nature. Traditional treatment methods are not able to produce satisfactory effects. Mesenchymal stem cells (MSCs) have shown great promise in cartilage repair. However, the therapeutic effect of MSCs is often unstable partly due to their heterogeneity. Understanding the heterogeneity of MSCs and the potential of different types of MSCs for cartilage regeneration will facilitate the selection of superior MSCs for treating cartilage damage. This review provides an overview of the heterogeneity of MSCs at the donor, tissue source and cell immunophenotype levels, including their cytological properties, such as their ability for proliferation, chondrogenic differentiation and immunoregulation, as well as their current applications in cartilage regeneration. This information will improve the precision of MSC-based therapeutic strategies, thus maximizing the efficiency of articular cartilage repair.
format	article
author	Kangkang Zha Xu Li Zhen Yang Guangzhao Tian Zhiqiang Sun Xiang Sui Yongjing Dai Shuyun Liu Quanyi Guo
author_facet	Kangkang Zha Xu Li Zhen Yang Guangzhao Tian Zhiqiang Sun Xiang Sui Yongjing Dai Shuyun Liu Quanyi Guo
author_sort	Kangkang Zha
title	Heterogeneity of mesenchymal stem cells in cartilage regeneration: from characterization to application
title_short	Heterogeneity of mesenchymal stem cells in cartilage regeneration: from characterization to application
title_full	Heterogeneity of mesenchymal stem cells in cartilage regeneration: from characterization to application
title_fullStr	Heterogeneity of mesenchymal stem cells in cartilage regeneration: from characterization to application
title_full_unstemmed	Heterogeneity of mesenchymal stem cells in cartilage regeneration: from characterization to application
title_sort	heterogeneity of mesenchymal stem cells in cartilage regeneration: from characterization to application
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/227d50a74b184d3abd2338a08d74e8a3
work_keys_str_mv	AT kangkangzha heterogeneityofmesenchymalstemcellsincartilageregenerationfromcharacterizationtoapplication AT xuli heterogeneityofmesenchymalstemcellsincartilageregenerationfromcharacterizationtoapplication AT zhenyang heterogeneityofmesenchymalstemcellsincartilageregenerationfromcharacterizationtoapplication AT guangzhaotian heterogeneityofmesenchymalstemcellsincartilageregenerationfromcharacterizationtoapplication AT zhiqiangsun heterogeneityofmesenchymalstemcellsincartilageregenerationfromcharacterizationtoapplication AT xiangsui heterogeneityofmesenchymalstemcellsincartilageregenerationfromcharacterizationtoapplication AT yongjingdai heterogeneityofmesenchymalstemcellsincartilageregenerationfromcharacterizationtoapplication AT shuyunliu heterogeneityofmesenchymalstemcellsincartilageregenerationfromcharacterizationtoapplication AT quanyiguo heterogeneityofmesenchymalstemcellsincartilageregenerationfromcharacterizationtoapplication
_version_	1718391357611966464

Heterogeneity of mesenchymal stem cells in cartilage regeneration: from characterization to application

Ejemplares similares