The effects of levosimendan on renal functions in open-heart surgery patients with a low ejection fraction

The effects of levosimendan on renal functions in open-heart surgery patients with a low ejection fraction

Purpose. This study investigated the effects of levosimendan on renal functions in patients with a preoperative low ejection fraction undergoing open-heart surgery and cardiopulmonary bypass (CPB). Materials and Methods. The study retrospectively evaluated 64 patients with a diagnosis of mitral valv...

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Autores principales: Süleyman Yazıcı, Mehmet N. Karabulut, Ayşe Baysal, Rahmi Zeybek
Formato: article
Lenguaje:EN
Publicado: Digital ProScholar Media 2021
Materias:
levosimendan
low ejection fraction
cardiopulmonary bypass
serum creatinine
Medicine
R
Acceso en línea:https://doaj.org/article/22800e4859124507bd3765b1c49d3323
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spelling oai:doaj.org-article:22800e4859124507bd3765b1c49d33232021-11-23T17:28:06ZThe effects of levosimendan on renal functions in open-heart surgery patients with a low ejection fraction10.25083/2559.5555/6.2.62559-5555https://doaj.org/article/22800e4859124507bd3765b1c49d33232021-11-01T00:00:00Zhttps://www.e-repository.org/jcis/6/2/6.pdfhttps://doaj.org/toc/2559-5555Purpose. This study investigated the effects of levosimendan on renal functions in patients with a preoperative low ejection fraction undergoing open-heart surgery and cardiopulmonary bypass (CPB). Materials and Methods. The study retrospectively evaluated 64 patients with a diagnosis of mitral valve insufficiency and left ventricular dysfunction undergoing open-heart surgery with CPB. Patients were divided depending on the preoperative blood creatinine level less (Group 1) or more than 1.2 mg/dL (Group 2). A bolus dose of levosimendan was administered through the aortic arch at the end of the CPB, preceding an infusion of levosimendan intravenously in all patients. Demographic data, preoperative and 48-hour postoperative echocardiographic studies were done. The blood urea and creatinine levels were collected preoperatively and on postoperative days 1, 3, and 10. The use of inotropic support, intra-aortic balloon pump, and complications were recorded. Results. The demographic data were similar between groups (p>0.05). Preoperative serum creatinine levels were higher in Group 1 in comparison to Group 2 (p=0.01, p<0.001, respectively). The aortic cross-clamp and cardiopulmonary bypass times were similar between groups (p>0.05). Preoperative serum creatinine levels were higher in Group 1 in comparison to Group 2 (p<0.001). On postoperative day 1, serum creatinine levels of Group 1 were significantly lower than Group 2 (p<0.001). On postoperative days 3 and 10, no differences were observed regarding serum creatinine levels between groups (p>0.05). Complications were similar between groups (p>0.05). Conclusions. In patients with low ejection fraction undergoing open-heart surgery, the use of levosimendan intraoperatively and 24 hours postoperatively prevents deterioration of renal functions in patients with or without preoperative disturbance in serum creatinine level.Süleyman YazıcıMehmet N. KarabulutAyşe BaysalRahmi ZeybekDigital ProScholar Mediaarticlelevosimendanlow ejection fractioncardiopulmonary bypassserum creatinineMedicineRENJournal of Clinical and Investigative Surgery, Vol 6, Iss 2, Pp 121-130 (2021)
institution DOAJ
collection DOAJ
language EN
topic levosimendan
low ejection fraction
cardiopulmonary bypass
serum creatinine
Medicine
R
spellingShingle levosimendan
low ejection fraction
cardiopulmonary bypass
serum creatinine
Medicine
R
Süleyman Yazıcı
Mehmet N. Karabulut
Ayşe Baysal
Rahmi Zeybek
The effects of levosimendan on renal functions in open-heart surgery patients with a low ejection fraction
description Purpose. This study investigated the effects of levosimendan on renal functions in patients with a preoperative low ejection fraction undergoing open-heart surgery and cardiopulmonary bypass (CPB). Materials and Methods. The study retrospectively evaluated 64 patients with a diagnosis of mitral valve insufficiency and left ventricular dysfunction undergoing open-heart surgery with CPB. Patients were divided depending on the preoperative blood creatinine level less (Group 1) or more than 1.2 mg/dL (Group 2). A bolus dose of levosimendan was administered through the aortic arch at the end of the CPB, preceding an infusion of levosimendan intravenously in all patients. Demographic data, preoperative and 48-hour postoperative echocardiographic studies were done. The blood urea and creatinine levels were collected preoperatively and on postoperative days 1, 3, and 10. The use of inotropic support, intra-aortic balloon pump, and complications were recorded. Results. The demographic data were similar between groups (p>0.05). Preoperative serum creatinine levels were higher in Group 1 in comparison to Group 2 (p=0.01, p<0.001, respectively). The aortic cross-clamp and cardiopulmonary bypass times were similar between groups (p>0.05). Preoperative serum creatinine levels were higher in Group 1 in comparison to Group 2 (p<0.001). On postoperative day 1, serum creatinine levels of Group 1 were significantly lower than Group 2 (p<0.001). On postoperative days 3 and 10, no differences were observed regarding serum creatinine levels between groups (p>0.05). Complications were similar between groups (p>0.05). Conclusions. In patients with low ejection fraction undergoing open-heart surgery, the use of levosimendan intraoperatively and 24 hours postoperatively prevents deterioration of renal functions in patients with or without preoperative disturbance in serum creatinine level.
format article
author Süleyman Yazıcı
Mehmet N. Karabulut
Ayşe Baysal
Rahmi Zeybek
author_facet Süleyman Yazıcı
Mehmet N. Karabulut
Ayşe Baysal
Rahmi Zeybek
author_sort Süleyman Yazıcı
title The effects of levosimendan on renal functions in open-heart surgery patients with a low ejection fraction
title_short The effects of levosimendan on renal functions in open-heart surgery patients with a low ejection fraction
title_full The effects of levosimendan on renal functions in open-heart surgery patients with a low ejection fraction
title_fullStr The effects of levosimendan on renal functions in open-heart surgery patients with a low ejection fraction
title_full_unstemmed The effects of levosimendan on renal functions in open-heart surgery patients with a low ejection fraction
title_sort effects of levosimendan on renal functions in open-heart surgery patients with a low ejection fraction
publisher Digital ProScholar Media
publishDate 2021
url https://doaj.org/article/22800e4859124507bd3765b1c49d3323
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