Caspr1 is a host receptor for meningitis-causing Escherichia coli
Penetration of the blood–brain barrier (BBB) is crucial for development of E. coli-caused meningitis. Here, the authors show that a host membrane protein, Caspr1, acts as a receptor for a bacterial virulence factor to facilitate BBB penetration and entry of E. coli into brain neurons.
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| Lenguaje: | EN |
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Nature Portfolio
2018
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| Acceso en línea: | https://doaj.org/article/2284a8655d2b415395c6982bdf49525d |
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oai:doaj.org-article:2284a8655d2b415395c6982bdf49525d2021-12-02T14:39:08ZCaspr1 is a host receptor for meningitis-causing Escherichia coli10.1038/s41467-018-04637-32041-1723https://doaj.org/article/2284a8655d2b415395c6982bdf49525d2018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04637-3https://doaj.org/toc/2041-1723Penetration of the blood–brain barrier (BBB) is crucial for development of E. coli-caused meningitis. Here, the authors show that a host membrane protein, Caspr1, acts as a receptor for a bacterial virulence factor to facilitate BBB penetration and entry of E. coli into brain neurons.Wei-Dong ZhaoDong-Xin LiuJia-Yi WeiZi-Wei MiaoKe ZhangZheng-Kang SuXue-Wei ZhangQiang LiWen-Gang FangXiao-Xue QinDe-Shu ShangBo LiQing-Chang LiLiu CaoKwang Sik KimYu-Hua ChenNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Wei-Dong Zhao Dong-Xin Liu Jia-Yi Wei Zi-Wei Miao Ke Zhang Zheng-Kang Su Xue-Wei Zhang Qiang Li Wen-Gang Fang Xiao-Xue Qin De-Shu Shang Bo Li Qing-Chang Li Liu Cao Kwang Sik Kim Yu-Hua Chen Caspr1 is a host receptor for meningitis-causing Escherichia coli |
| description |
Penetration of the blood–brain barrier (BBB) is crucial for development of E. coli-caused meningitis. Here, the authors show that a host membrane protein, Caspr1, acts as a receptor for a bacterial virulence factor to facilitate BBB penetration and entry of E. coli into brain neurons. |
| format |
article |
| author |
Wei-Dong Zhao Dong-Xin Liu Jia-Yi Wei Zi-Wei Miao Ke Zhang Zheng-Kang Su Xue-Wei Zhang Qiang Li Wen-Gang Fang Xiao-Xue Qin De-Shu Shang Bo Li Qing-Chang Li Liu Cao Kwang Sik Kim Yu-Hua Chen |
| author_facet |
Wei-Dong Zhao Dong-Xin Liu Jia-Yi Wei Zi-Wei Miao Ke Zhang Zheng-Kang Su Xue-Wei Zhang Qiang Li Wen-Gang Fang Xiao-Xue Qin De-Shu Shang Bo Li Qing-Chang Li Liu Cao Kwang Sik Kim Yu-Hua Chen |
| author_sort |
Wei-Dong Zhao |
| title |
Caspr1 is a host receptor for meningitis-causing Escherichia coli |
| title_short |
Caspr1 is a host receptor for meningitis-causing Escherichia coli |
| title_full |
Caspr1 is a host receptor for meningitis-causing Escherichia coli |
| title_fullStr |
Caspr1 is a host receptor for meningitis-causing Escherichia coli |
| title_full_unstemmed |
Caspr1 is a host receptor for meningitis-causing Escherichia coli |
| title_sort |
caspr1 is a host receptor for meningitis-causing escherichia coli |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/2284a8655d2b415395c6982bdf49525d |
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