Synaptotagmin 17 controls neurite outgrowth and synaptic physiology via distinct cellular pathways

The functional role of synaptotagmin-17 (syt-17) has remained unanswered. In this study, authors demonstrate that syt-17 exists in two distinct pools in hippocampal neurons (Golgi complex and early endosomes), where it served two completely independent functions: controlling neurite outgrowth and sy...

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Autores principales:	David A. Ruhl, Ewa Bomba-Warczak, Emma T. Watson, Mazdak M. Bradberry, Tabitha A. Peterson, Trina Basu, Alyssa Frelka, Chantell S. Evans, Joseph S. Briguglio, Tamara Basta, Michael H. B. Stowell, Jeffrey N. Savas, Avtar Roopra, Robert A. Pearce, Robert C. Piper, Edwin R. Chapman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2285b841eadf401cae3e662ea7ba2f42
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spelling	oai:doaj.org-article:2285b841eadf401cae3e662ea7ba2f422021-12-02T17:01:40ZSynaptotagmin 17 controls neurite outgrowth and synaptic physiology via distinct cellular pathways10.1038/s41467-019-11459-42041-1723https://doaj.org/article/2285b841eadf401cae3e662ea7ba2f422019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11459-4https://doaj.org/toc/2041-1723The functional role of synaptotagmin-17 (syt-17) has remained unanswered. In this study, authors demonstrate that syt-17 exists in two distinct pools in hippocampal neurons (Golgi complex and early endosomes), where it served two completely independent functions: controlling neurite outgrowth and synaptic physiologyDavid A. RuhlEwa Bomba-WarczakEmma T. WatsonMazdak M. BradberryTabitha A. PetersonTrina BasuAlyssa FrelkaChantell S. EvansJoseph S. BriguglioTamara BastaMichael H. B. StowellJeffrey N. SavasAvtar RoopraRobert A. PearceRobert C. PiperEdwin R. ChapmanNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q David A. Ruhl Ewa Bomba-Warczak Emma T. Watson Mazdak M. Bradberry Tabitha A. Peterson Trina Basu Alyssa Frelka Chantell S. Evans Joseph S. Briguglio Tamara Basta Michael H. B. Stowell Jeffrey N. Savas Avtar Roopra Robert A. Pearce Robert C. Piper Edwin R. Chapman Synaptotagmin 17 controls neurite outgrowth and synaptic physiology via distinct cellular pathways
description	The functional role of synaptotagmin-17 (syt-17) has remained unanswered. In this study, authors demonstrate that syt-17 exists in two distinct pools in hippocampal neurons (Golgi complex and early endosomes), where it served two completely independent functions: controlling neurite outgrowth and synaptic physiology
format	article
author	David A. Ruhl Ewa Bomba-Warczak Emma T. Watson Mazdak M. Bradberry Tabitha A. Peterson Trina Basu Alyssa Frelka Chantell S. Evans Joseph S. Briguglio Tamara Basta Michael H. B. Stowell Jeffrey N. Savas Avtar Roopra Robert A. Pearce Robert C. Piper Edwin R. Chapman
author_facet	David A. Ruhl Ewa Bomba-Warczak Emma T. Watson Mazdak M. Bradberry Tabitha A. Peterson Trina Basu Alyssa Frelka Chantell S. Evans Joseph S. Briguglio Tamara Basta Michael H. B. Stowell Jeffrey N. Savas Avtar Roopra Robert A. Pearce Robert C. Piper Edwin R. Chapman
author_sort	David A. Ruhl
title	Synaptotagmin 17 controls neurite outgrowth and synaptic physiology via distinct cellular pathways
title_short	Synaptotagmin 17 controls neurite outgrowth and synaptic physiology via distinct cellular pathways
title_full	Synaptotagmin 17 controls neurite outgrowth and synaptic physiology via distinct cellular pathways
title_fullStr	Synaptotagmin 17 controls neurite outgrowth and synaptic physiology via distinct cellular pathways
title_full_unstemmed	Synaptotagmin 17 controls neurite outgrowth and synaptic physiology via distinct cellular pathways
title_sort	synaptotagmin 17 controls neurite outgrowth and synaptic physiology via distinct cellular pathways
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/2285b841eadf401cae3e662ea7ba2f42
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Synaptotagmin 17 controls neurite outgrowth and synaptic physiology via distinct cellular pathways

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