Clonal yet Different: Understanding the Causes of Genomic Heterogeneity in Microbial Species and Impacts on Public Health

ABSTRACT Why are members of a microbial species not the same? They may be clonal, but microbial populations are often composed of multiple cocirculating lineages distinguished by large phenotypic and genetic differences. Species and the mechanisms of speciation have been notoriously challenging to s...

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Autor principal:	Cheryl P. Andam
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2019
Materias:	bacterial pathogens microbial evolution microbial population genomics Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/2286f8c2d6fc4a7cb19bdeb6214ed599
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spelling	oai:doaj.org-article:2286f8c2d6fc4a7cb19bdeb6214ed5992021-12-02T18:25:17ZClonal yet Different: Understanding the Causes of Genomic Heterogeneity in Microbial Species and Impacts on Public Health10.1128/mSystems.00097-192379-5077https://doaj.org/article/2286f8c2d6fc4a7cb19bdeb6214ed5992019-06-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSystems.00097-19https://doaj.org/toc/2379-5077ABSTRACT Why are members of a microbial species not the same? They may be clonal, but microbial populations are often composed of multiple cocirculating lineages distinguished by large phenotypic and genetic differences. Species and the mechanisms of speciation have been notoriously challenging to study in microbes owing to pervasive horizontal gene flow, widespread geographical distribution, and cryptic ecological niches that structure microbial populations. Understanding the origins of genomic variation in microbial species and populations is fundamental to questions critical to society and public health, such as “Are emerging diseases new species or variants of existing ones?,” “What makes a resistant strain successful?,” and “How will a pathogen respond to selective pressures?” To explore these questions, I use whole-genome sequencing of closely related strains to understand the evolutionary, ecological, and epidemiological dynamics of bacterial pathogens to inform effective, more precisely targeted public health interventions.Cheryl P. AndamAmerican Society for Microbiologyarticlebacterial pathogensmicrobial evolutionmicrobial population genomicsMicrobiologyQR1-502ENmSystems, Vol 4, Iss 3 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	bacterial pathogens microbial evolution microbial population genomics Microbiology QR1-502
spellingShingle	bacterial pathogens microbial evolution microbial population genomics Microbiology QR1-502 Cheryl P. Andam Clonal yet Different: Understanding the Causes of Genomic Heterogeneity in Microbial Species and Impacts on Public Health
description	ABSTRACT Why are members of a microbial species not the same? They may be clonal, but microbial populations are often composed of multiple cocirculating lineages distinguished by large phenotypic and genetic differences. Species and the mechanisms of speciation have been notoriously challenging to study in microbes owing to pervasive horizontal gene flow, widespread geographical distribution, and cryptic ecological niches that structure microbial populations. Understanding the origins of genomic variation in microbial species and populations is fundamental to questions critical to society and public health, such as “Are emerging diseases new species or variants of existing ones?,” “What makes a resistant strain successful?,” and “How will a pathogen respond to selective pressures?” To explore these questions, I use whole-genome sequencing of closely related strains to understand the evolutionary, ecological, and epidemiological dynamics of bacterial pathogens to inform effective, more precisely targeted public health interventions.
format	article
author	Cheryl P. Andam
author_facet	Cheryl P. Andam
author_sort	Cheryl P. Andam
title	Clonal yet Different: Understanding the Causes of Genomic Heterogeneity in Microbial Species and Impacts on Public Health
title_short	Clonal yet Different: Understanding the Causes of Genomic Heterogeneity in Microbial Species and Impacts on Public Health
title_full	Clonal yet Different: Understanding the Causes of Genomic Heterogeneity in Microbial Species and Impacts on Public Health
title_fullStr	Clonal yet Different: Understanding the Causes of Genomic Heterogeneity in Microbial Species and Impacts on Public Health
title_full_unstemmed	Clonal yet Different: Understanding the Causes of Genomic Heterogeneity in Microbial Species and Impacts on Public Health
title_sort	clonal yet different: understanding the causes of genomic heterogeneity in microbial species and impacts on public health
publisher	American Society for Microbiology
publishDate	2019
url	https://doaj.org/article/2286f8c2d6fc4a7cb19bdeb6214ed599
work_keys_str_mv	AT cherylpandam clonalyetdifferentunderstandingthecausesofgenomicheterogeneityinmicrobialspeciesandimpactsonpublichealth
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Clonal yet Different: Understanding the Causes of Genomic Heterogeneity in Microbial Species and Impacts on Public Health

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