Transient microglial absence assists postmigratory cortical neurons in proper differentiation

Microglia temporarily disappear from the cortical plate in the midembryonic stage. This study demonstrated that microglial transient absence from the cortical plate is required for postmigratory neurons to appropriately fine-tune the expression of molecules needed for their proper differentiation.

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Autores principales:	Yuki Hattori, Yu Naito, Yoji Tsugawa, Shigenori Nonaka, Hiroaki Wake, Takashi Nagasawa, Ayano Kawaguchi, Takaki Miyata
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/228777daf6424d718afb037c8a743819
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spelling	oai:doaj.org-article:228777daf6424d718afb037c8a7438192021-12-02T16:49:45ZTransient microglial absence assists postmigratory cortical neurons in proper differentiation10.1038/s41467-020-15409-32041-1723https://doaj.org/article/228777daf6424d718afb037c8a7438192020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15409-3https://doaj.org/toc/2041-1723Microglia temporarily disappear from the cortical plate in the midembryonic stage. This study demonstrated that microglial transient absence from the cortical plate is required for postmigratory neurons to appropriately fine-tune the expression of molecules needed for their proper differentiation.Yuki HattoriYu NaitoYoji TsugawaShigenori NonakaHiroaki WakeTakashi NagasawaAyano KawaguchiTakaki MiyataNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yuki Hattori Yu Naito Yoji Tsugawa Shigenori Nonaka Hiroaki Wake Takashi Nagasawa Ayano Kawaguchi Takaki Miyata Transient microglial absence assists postmigratory cortical neurons in proper differentiation
description	Microglia temporarily disappear from the cortical plate in the midembryonic stage. This study demonstrated that microglial transient absence from the cortical plate is required for postmigratory neurons to appropriately fine-tune the expression of molecules needed for their proper differentiation.
format	article
author	Yuki Hattori Yu Naito Yoji Tsugawa Shigenori Nonaka Hiroaki Wake Takashi Nagasawa Ayano Kawaguchi Takaki Miyata
author_facet	Yuki Hattori Yu Naito Yoji Tsugawa Shigenori Nonaka Hiroaki Wake Takashi Nagasawa Ayano Kawaguchi Takaki Miyata
author_sort	Yuki Hattori
title	Transient microglial absence assists postmigratory cortical neurons in proper differentiation
title_short	Transient microglial absence assists postmigratory cortical neurons in proper differentiation
title_full	Transient microglial absence assists postmigratory cortical neurons in proper differentiation
title_fullStr	Transient microglial absence assists postmigratory cortical neurons in proper differentiation
title_full_unstemmed	Transient microglial absence assists postmigratory cortical neurons in proper differentiation
title_sort	transient microglial absence assists postmigratory cortical neurons in proper differentiation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/228777daf6424d718afb037c8a743819
work_keys_str_mv	AT yukihattori transientmicroglialabsenceassistspostmigratorycorticalneuronsinproperdifferentiation AT yunaito transientmicroglialabsenceassistspostmigratorycorticalneuronsinproperdifferentiation AT yojitsugawa transientmicroglialabsenceassistspostmigratorycorticalneuronsinproperdifferentiation AT shigenorinonaka transientmicroglialabsenceassistspostmigratorycorticalneuronsinproperdifferentiation AT hiroakiwake transientmicroglialabsenceassistspostmigratorycorticalneuronsinproperdifferentiation AT takashinagasawa transientmicroglialabsenceassistspostmigratorycorticalneuronsinproperdifferentiation AT ayanokawaguchi transientmicroglialabsenceassistspostmigratorycorticalneuronsinproperdifferentiation AT takakimiyata transientmicroglialabsenceassistspostmigratorycorticalneuronsinproperdifferentiation
_version_	1718383202508210176

Transient microglial absence assists postmigratory cortical neurons in proper differentiation

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