Predictive utility of fibrinogen in acute kidney injury in living donor liver transplantation: A propensity score-matching analysis.

<h4>Background</h4>This study investigated the association between the fibrinogen level and the risk of acute kidney injury (AKI) in patients who have undergone living donor liver transplantation (LDLT).<h4>Patients and methods</h4>A total of 676 patients who underwent LDLT w...

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Autores principales:	Jaesik Park, Min A Joo, Ho Joong Choi, Sang Hyun Hong, Chul Soo Park, Jong Ho Choi, Min Suk Chae
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/22894a8577b844db9acfe129e996fcaa
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spelling	oai:doaj.org-article:22894a8577b844db9acfe129e996fcaa2021-12-02T20:07:16ZPredictive utility of fibrinogen in acute kidney injury in living donor liver transplantation: A propensity score-matching analysis.1932-620310.1371/journal.pone.0252715https://doaj.org/article/22894a8577b844db9acfe129e996fcaa2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0252715https://doaj.org/toc/1932-6203<h4>Background</h4>This study investigated the association between the fibrinogen level and the risk of acute kidney injury (AKI) in patients who have undergone living donor liver transplantation (LDLT).<h4>Patients and methods</h4>A total of 676 patients who underwent LDLT were analyzed retrospectively. Exclusion criteria included a history of severe kidney dysfunction, emergency operation, deceased donor, ABO-incompatible transplantation, and missing data. The study population was divided into low and normal fibrinogen groups. A 1:1 propensity score (PS) matching analysis was used to evaluate the association between a low fibrinogen level (< 160 mg/dL) and postoperative development of AKI.<h4>Results</h4>In total, 142 patients (23.1%) developed AKI after LDLT. The PS matching analysis showed that the probability of AKI was two-fold higher in the low fibrinogen group than in the normal fibrinogen group. In addition, patients with AKI had poorer postoperative outcomes such as longer hospitalization, longer ICU stay, and higher mortality than patients without AKI.<h4>Conclusions</h4>The preoperative fibrinogen level may be useful for risk stratification of patients undergoing LDLT in terms postoperative development of AKI.Jaesik ParkMin A JooHo Joong ChoiSang Hyun HongChul Soo ParkJong Ho ChoiMin Suk ChaePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 6, p e0252715 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jaesik Park Min A Joo Ho Joong Choi Sang Hyun Hong Chul Soo Park Jong Ho Choi Min Suk Chae Predictive utility of fibrinogen in acute kidney injury in living donor liver transplantation: A propensity score-matching analysis.
description	<h4>Background</h4>This study investigated the association between the fibrinogen level and the risk of acute kidney injury (AKI) in patients who have undergone living donor liver transplantation (LDLT).<h4>Patients and methods</h4>A total of 676 patients who underwent LDLT were analyzed retrospectively. Exclusion criteria included a history of severe kidney dysfunction, emergency operation, deceased donor, ABO-incompatible transplantation, and missing data. The study population was divided into low and normal fibrinogen groups. A 1:1 propensity score (PS) matching analysis was used to evaluate the association between a low fibrinogen level (< 160 mg/dL) and postoperative development of AKI.<h4>Results</h4>In total, 142 patients (23.1%) developed AKI after LDLT. The PS matching analysis showed that the probability of AKI was two-fold higher in the low fibrinogen group than in the normal fibrinogen group. In addition, patients with AKI had poorer postoperative outcomes such as longer hospitalization, longer ICU stay, and higher mortality than patients without AKI.<h4>Conclusions</h4>The preoperative fibrinogen level may be useful for risk stratification of patients undergoing LDLT in terms postoperative development of AKI.
format	article
author	Jaesik Park Min A Joo Ho Joong Choi Sang Hyun Hong Chul Soo Park Jong Ho Choi Min Suk Chae
author_facet	Jaesik Park Min A Joo Ho Joong Choi Sang Hyun Hong Chul Soo Park Jong Ho Choi Min Suk Chae
author_sort	Jaesik Park
title	Predictive utility of fibrinogen in acute kidney injury in living donor liver transplantation: A propensity score-matching analysis.
title_short	Predictive utility of fibrinogen in acute kidney injury in living donor liver transplantation: A propensity score-matching analysis.
title_full	Predictive utility of fibrinogen in acute kidney injury in living donor liver transplantation: A propensity score-matching analysis.
title_fullStr	Predictive utility of fibrinogen in acute kidney injury in living donor liver transplantation: A propensity score-matching analysis.
title_full_unstemmed	Predictive utility of fibrinogen in acute kidney injury in living donor liver transplantation: A propensity score-matching analysis.
title_sort	predictive utility of fibrinogen in acute kidney injury in living donor liver transplantation: a propensity score-matching analysis.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/22894a8577b844db9acfe129e996fcaa
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Predictive utility of fibrinogen in acute kidney injury in living donor liver transplantation: A propensity score-matching analysis.

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