Force-induced increased osteogenesis enables accelerated orthodontic tooth movement in ovariectomized rats

Abstract As the number of elderly orthodontic patients increases, the impact of postmenopausal osteoporosis on orthodontic tooth movement (OTM) has attracted a great deal of attention because OTM relies on alveolar bone remodeling. The question of whether OTM causes subsequent alveolar bone loss and...

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Autores principales:	Qinggang Dai, Siru Zhou, Peng Zhang, Xuhui Ma, Nayong Ha, Xiao Yang, Zhifeng Yu, Bing Fang, Lingyong Jiang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/228993deadf54cd3a23d5646bf2c9e66
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spelling	oai:doaj.org-article:228993deadf54cd3a23d5646bf2c9e662021-12-02T16:06:44ZForce-induced increased osteogenesis enables accelerated orthodontic tooth movement in ovariectomized rats10.1038/s41598-017-04422-02045-2322https://doaj.org/article/228993deadf54cd3a23d5646bf2c9e662017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04422-0https://doaj.org/toc/2045-2322Abstract As the number of elderly orthodontic patients increases, the impact of postmenopausal osteoporosis on orthodontic tooth movement (OTM) has attracted a great deal of attention because OTM relies on alveolar bone remodeling. The question of whether OTM causes subsequent alveolar bone loss and is harmful to alveolar bone health under osteoporotic conditions remains to be answered. The present study aimed to clarify the influences of OTM on alveolar bone in osteoporotic rats. OTM was accelerated in ovariectomized (OVX) rats as a result of increased bone resorption in the pressure area. At the same time, anabolic bone formation was promoted in the tension area during OTM in OVX rats. Micro-CT analysis of alveolar bone revealed a decrease in BMD, BV/TV and Tb.Th. in the OTM group compared with that in non-OTM rats on day 21 of OTM, suggesting that OTM caused alveolar bone loss in OVX rats during OTM. However, the OTM-induced bone loss could be recovered 3 months after OTM in OVX rats. Thus, our findings suggest that increased osteogenesis may compensate for the increased bone resorption during and after OTM and enable effective accelerated OTM in OVX rats.Qinggang DaiSiru ZhouPeng ZhangXuhui MaNayong HaXiao YangZhifeng YuBing FangLingyong JiangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Qinggang Dai Siru Zhou Peng Zhang Xuhui Ma Nayong Ha Xiao Yang Zhifeng Yu Bing Fang Lingyong Jiang Force-induced increased osteogenesis enables accelerated orthodontic tooth movement in ovariectomized rats
description	Abstract As the number of elderly orthodontic patients increases, the impact of postmenopausal osteoporosis on orthodontic tooth movement (OTM) has attracted a great deal of attention because OTM relies on alveolar bone remodeling. The question of whether OTM causes subsequent alveolar bone loss and is harmful to alveolar bone health under osteoporotic conditions remains to be answered. The present study aimed to clarify the influences of OTM on alveolar bone in osteoporotic rats. OTM was accelerated in ovariectomized (OVX) rats as a result of increased bone resorption in the pressure area. At the same time, anabolic bone formation was promoted in the tension area during OTM in OVX rats. Micro-CT analysis of alveolar bone revealed a decrease in BMD, BV/TV and Tb.Th. in the OTM group compared with that in non-OTM rats on day 21 of OTM, suggesting that OTM caused alveolar bone loss in OVX rats during OTM. However, the OTM-induced bone loss could be recovered 3 months after OTM in OVX rats. Thus, our findings suggest that increased osteogenesis may compensate for the increased bone resorption during and after OTM and enable effective accelerated OTM in OVX rats.
format	article
author	Qinggang Dai Siru Zhou Peng Zhang Xuhui Ma Nayong Ha Xiao Yang Zhifeng Yu Bing Fang Lingyong Jiang
author_facet	Qinggang Dai Siru Zhou Peng Zhang Xuhui Ma Nayong Ha Xiao Yang Zhifeng Yu Bing Fang Lingyong Jiang
author_sort	Qinggang Dai
title	Force-induced increased osteogenesis enables accelerated orthodontic tooth movement in ovariectomized rats
title_short	Force-induced increased osteogenesis enables accelerated orthodontic tooth movement in ovariectomized rats
title_full	Force-induced increased osteogenesis enables accelerated orthodontic tooth movement in ovariectomized rats
title_fullStr	Force-induced increased osteogenesis enables accelerated orthodontic tooth movement in ovariectomized rats
title_full_unstemmed	Force-induced increased osteogenesis enables accelerated orthodontic tooth movement in ovariectomized rats
title_sort	force-induced increased osteogenesis enables accelerated orthodontic tooth movement in ovariectomized rats
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/228993deadf54cd3a23d5646bf2c9e66
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Force-induced increased osteogenesis enables accelerated orthodontic tooth movement in ovariectomized rats

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