Small nucleolar RNA 42 promotes the growth of hepatocellular carcinoma through the p53 signaling pathway

Abstract Recent studies show that small nucleolar RNAs (snoRNAs) play an important role in tumorigenesis. SNORA42 is a potential therapeutic target and prognostic biomarker for various cancers, and the aim of the present study was to investigate the function and clinical relevance of SNORA42 in hepa...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ganggang Wang, Jinghua Li, Ye Yao, Yingyi Liu, Peng Xia, Hao Zhang, Maohui Yin, Zhixiang Qin, Weijie Ma, Yufeng Yuan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Publishing Group 2021
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Cytology QH573-671
Acceso en línea:	https://doaj.org/article/228af5d1430445a3a27dc6f6d37b6018
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:228af5d1430445a3a27dc6f6d37b6018
record_format	dspace
spelling	oai:doaj.org-article:228af5d1430445a3a27dc6f6d37b60182021-11-14T12:12:29ZSmall nucleolar RNA 42 promotes the growth of hepatocellular carcinoma through the p53 signaling pathway10.1038/s41420-021-00740-52058-7716https://doaj.org/article/228af5d1430445a3a27dc6f6d37b60182021-11-01T00:00:00Zhttps://doi.org/10.1038/s41420-021-00740-5https://doaj.org/toc/2058-7716Abstract Recent studies show that small nucleolar RNAs (snoRNAs) play an important role in tumorigenesis. SNORA42 is a potential therapeutic target and prognostic biomarker for various cancers, and the aim of the present study was to investigate the function and clinical relevance of SNORA42 in hepatocellular carcinoma (HCC). We detected the expression levels of SNORA42 in HCC and normal liver tissue samples, as well as in tumor and hepatocyte-derived cell lines. SNORA42 was significantly upregulated in the HCC tissues and cells compared to the adjacent liver tissues and normal hepatocytes. Furthermore, overexpression of SNORA42 correlated with poor prognosis in the HCC patients. Knocking down SNORA42 in HCC cell lines decreased their proliferation, migration and invasion in vitro, and inhibited tumor growth and metastasis in vivo. In contrast, ectopic expression of SNORA42 promoted HCC cell proliferation and inhibited apoptosis. Mechanistically, SNORA42 exerted its oncogenic effects by targeting the p53 signaling pathway and cell cycle transition. In conclusion, SNORA42 acted as an oncogene in HCC and was a potential prognostic biomarker and therapeutic target.Ganggang WangJinghua LiYe YaoYingyi LiuPeng XiaHao ZhangMaohui YinZhixiang QinWeijie MaYufeng YuanNature Publishing GrouparticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282CytologyQH573-671ENCell Death Discovery, Vol 7, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Cytology QH573-671
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Cytology QH573-671 Ganggang Wang Jinghua Li Ye Yao Yingyi Liu Peng Xia Hao Zhang Maohui Yin Zhixiang Qin Weijie Ma Yufeng Yuan Small nucleolar RNA 42 promotes the growth of hepatocellular carcinoma through the p53 signaling pathway
description	Abstract Recent studies show that small nucleolar RNAs (snoRNAs) play an important role in tumorigenesis. SNORA42 is a potential therapeutic target and prognostic biomarker for various cancers, and the aim of the present study was to investigate the function and clinical relevance of SNORA42 in hepatocellular carcinoma (HCC). We detected the expression levels of SNORA42 in HCC and normal liver tissue samples, as well as in tumor and hepatocyte-derived cell lines. SNORA42 was significantly upregulated in the HCC tissues and cells compared to the adjacent liver tissues and normal hepatocytes. Furthermore, overexpression of SNORA42 correlated with poor prognosis in the HCC patients. Knocking down SNORA42 in HCC cell lines decreased their proliferation, migration and invasion in vitro, and inhibited tumor growth and metastasis in vivo. In contrast, ectopic expression of SNORA42 promoted HCC cell proliferation and inhibited apoptosis. Mechanistically, SNORA42 exerted its oncogenic effects by targeting the p53 signaling pathway and cell cycle transition. In conclusion, SNORA42 acted as an oncogene in HCC and was a potential prognostic biomarker and therapeutic target.
format	article
author	Ganggang Wang Jinghua Li Ye Yao Yingyi Liu Peng Xia Hao Zhang Maohui Yin Zhixiang Qin Weijie Ma Yufeng Yuan
author_facet	Ganggang Wang Jinghua Li Ye Yao Yingyi Liu Peng Xia Hao Zhang Maohui Yin Zhixiang Qin Weijie Ma Yufeng Yuan
author_sort	Ganggang Wang
title	Small nucleolar RNA 42 promotes the growth of hepatocellular carcinoma through the p53 signaling pathway
title_short	Small nucleolar RNA 42 promotes the growth of hepatocellular carcinoma through the p53 signaling pathway
title_full	Small nucleolar RNA 42 promotes the growth of hepatocellular carcinoma through the p53 signaling pathway
title_fullStr	Small nucleolar RNA 42 promotes the growth of hepatocellular carcinoma through the p53 signaling pathway
title_full_unstemmed	Small nucleolar RNA 42 promotes the growth of hepatocellular carcinoma through the p53 signaling pathway
title_sort	small nucleolar rna 42 promotes the growth of hepatocellular carcinoma through the p53 signaling pathway
publisher	Nature Publishing Group
publishDate	2021
url	https://doaj.org/article/228af5d1430445a3a27dc6f6d37b6018
work_keys_str_mv	AT ganggangwang smallnucleolarrna42promotesthegrowthofhepatocellularcarcinomathroughthep53signalingpathway AT jinghuali smallnucleolarrna42promotesthegrowthofhepatocellularcarcinomathroughthep53signalingpathway AT yeyao smallnucleolarrna42promotesthegrowthofhepatocellularcarcinomathroughthep53signalingpathway AT yingyiliu smallnucleolarrna42promotesthegrowthofhepatocellularcarcinomathroughthep53signalingpathway AT pengxia smallnucleolarrna42promotesthegrowthofhepatocellularcarcinomathroughthep53signalingpathway AT haozhang smallnucleolarrna42promotesthegrowthofhepatocellularcarcinomathroughthep53signalingpathway AT maohuiyin smallnucleolarrna42promotesthegrowthofhepatocellularcarcinomathroughthep53signalingpathway AT zhixiangqin smallnucleolarrna42promotesthegrowthofhepatocellularcarcinomathroughthep53signalingpathway AT weijiema smallnucleolarrna42promotesthegrowthofhepatocellularcarcinomathroughthep53signalingpathway AT yufengyuan smallnucleolarrna42promotesthegrowthofhepatocellularcarcinomathroughthep53signalingpathway
_version_	1718429334113353728

Small nucleolar RNA 42 promotes the growth of hepatocellular carcinoma through the p53 signaling pathway

Ejemplares similares