Novel β-Lactamase <italic toggle="yes">bla</italic><sub>ARL</sub> in <named-content content-type="genus-species">Staphylococcus arlettae</named-content>
ABSTRACT Whole-genome sequencing of penicillin-resistant Staphylococcus arlettae strain SAN1670 from bovine mastitis milk revealed a novel β-lactamase operon consisting of the β-lactamase-encoding gene blaARL, the antirepressor-encoding gene blaR1ARL, and the repressor-encoding gene blaIARL. The fun...
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American Society for Microbiology
2017
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oai:doaj.org-article:228d2589a8a44f1a9fe7b9ca2eda70cd2021-11-15T15:21:47ZNovel β-Lactamase <italic toggle="yes">bla</italic><sub>ARL</sub> in <named-content content-type="genus-species">Staphylococcus arlettae</named-content>10.1128/mSphere.00117-172379-5042https://doaj.org/article/228d2589a8a44f1a9fe7b9ca2eda70cd2017-06-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSphere.00117-17https://doaj.org/toc/2379-5042ABSTRACT Whole-genome sequencing of penicillin-resistant Staphylococcus arlettae strain SAN1670 from bovine mastitis milk revealed a novel β-lactamase operon consisting of the β-lactamase-encoding gene blaARL, the antirepressor-encoding gene blaR1ARL, and the repressor-encoding gene blaIARL. The functionality of blaARL was demonstrated by gene expression in Staphylococcus aureus. The blaARL operon was chromosomally located in SAN1670 and present in 10 additional unrelated strains, suggesting intrinsic penicillin resistance in S. arlettae. Furthermore, a GenBank search revealed more unique potential β-lactamases in Staphylococcus species. IMPORTANCE Penicillins are an important group of antibiotics used to treat various types of infections caused by Gram-positive bacteria. So far, the blaZ gene was the only known β-lactamase gene in staphylococci. However, other putative β-lactamases were identified, and one of them was shown to be a novel functional β-lactamase encoded by blaARL in Staphylococcus arlettae, further limiting treatment options.Sabrina N. AndreisVincent PerretenSybille SchwendenerAmerican Society for Microbiologyarticleantibiotic resistancebeta-lactamasescoagulase-negative staphylococcipenicillinaseMicrobiologyQR1-502ENmSphere, Vol 2, Iss 3 (2017) |
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DOAJ |
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DOAJ |
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EN |
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antibiotic resistance beta-lactamases coagulase-negative staphylococci penicillinase Microbiology QR1-502 |
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antibiotic resistance beta-lactamases coagulase-negative staphylococci penicillinase Microbiology QR1-502 Sabrina N. Andreis Vincent Perreten Sybille Schwendener Novel β-Lactamase <italic toggle="yes">bla</italic><sub>ARL</sub> in <named-content content-type="genus-species">Staphylococcus arlettae</named-content> |
| description |
ABSTRACT Whole-genome sequencing of penicillin-resistant Staphylococcus arlettae strain SAN1670 from bovine mastitis milk revealed a novel β-lactamase operon consisting of the β-lactamase-encoding gene blaARL, the antirepressor-encoding gene blaR1ARL, and the repressor-encoding gene blaIARL. The functionality of blaARL was demonstrated by gene expression in Staphylococcus aureus. The blaARL operon was chromosomally located in SAN1670 and present in 10 additional unrelated strains, suggesting intrinsic penicillin resistance in S. arlettae. Furthermore, a GenBank search revealed more unique potential β-lactamases in Staphylococcus species. IMPORTANCE Penicillins are an important group of antibiotics used to treat various types of infections caused by Gram-positive bacteria. So far, the blaZ gene was the only known β-lactamase gene in staphylococci. However, other putative β-lactamases were identified, and one of them was shown to be a novel functional β-lactamase encoded by blaARL in Staphylococcus arlettae, further limiting treatment options. |
| format |
article |
| author |
Sabrina N. Andreis Vincent Perreten Sybille Schwendener |
| author_facet |
Sabrina N. Andreis Vincent Perreten Sybille Schwendener |
| author_sort |
Sabrina N. Andreis |
| title |
Novel β-Lactamase <italic toggle="yes">bla</italic><sub>ARL</sub> in <named-content content-type="genus-species">Staphylococcus arlettae</named-content> |
| title_short |
Novel β-Lactamase <italic toggle="yes">bla</italic><sub>ARL</sub> in <named-content content-type="genus-species">Staphylococcus arlettae</named-content> |
| title_full |
Novel β-Lactamase <italic toggle="yes">bla</italic><sub>ARL</sub> in <named-content content-type="genus-species">Staphylococcus arlettae</named-content> |
| title_fullStr |
Novel β-Lactamase <italic toggle="yes">bla</italic><sub>ARL</sub> in <named-content content-type="genus-species">Staphylococcus arlettae</named-content> |
| title_full_unstemmed |
Novel β-Lactamase <italic toggle="yes">bla</italic><sub>ARL</sub> in <named-content content-type="genus-species">Staphylococcus arlettae</named-content> |
| title_sort |
novel β-lactamase <italic toggle="yes">bla</italic><sub>arl</sub> in <named-content content-type="genus-species">staphylococcus arlettae</named-content> |
| publisher |
American Society for Microbiology |
| publishDate |
2017 |
| url |
https://doaj.org/article/228d2589a8a44f1a9fe7b9ca2eda70cd |
| work_keys_str_mv |
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