Crizotinib-induced immunogenic cell death in non-small cell lung cancer

Certain chemotherapeutic agents can exert their anticancer effect through indirect immune-dependent mechanism. Here, the authors screen a library of tyrosine kinase inhibitors and show that crizotinib is an effective stimulator of immunogenic cell death and can potentiate the efficacy of immune chec...

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Autores principales:	Peng Liu, Liwei Zhao, Jonathan Pol, Sarah Levesque, Adriana Petrazzuolo, Christina Pfirschke, Camilla Engblom, Steffen Rickelt, Takahiro Yamazaki, Kristina Iribarren, Laura Senovilla, Lucillia Bezu, Erika Vacchelli, Valentina Sica, Andréa Melis, Tiffany Martin, Lin Xia, Heng Yang, Qingqing Li, Jinfeng Chen, Sylvère Durand, Fanny Aprahamian, Deborah Lefevre, Sophie Broutin, Angelo Paci, Amaury Bongers, Veronique Minard-Colin, Eric Tartour, Laurence Zitvogel, Lionel Apetoh, Yuting Ma, Mikael J. Pittet, Oliver Kepp, Guido Kroemer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/228ee56caf814e7fbcca341ed093aaed
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spelling	oai:doaj.org-article:228ee56caf814e7fbcca341ed093aaed2021-12-02T16:58:18ZCrizotinib-induced immunogenic cell death in non-small cell lung cancer10.1038/s41467-019-09415-32041-1723https://doaj.org/article/228ee56caf814e7fbcca341ed093aaed2019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09415-3https://doaj.org/toc/2041-1723Certain chemotherapeutic agents can exert their anticancer effect through indirect immune-dependent mechanism. Here, the authors screen a library of tyrosine kinase inhibitors and show that crizotinib is an effective stimulator of immunogenic cell death and can potentiate the efficacy of immune checkpoint blockade.Peng LiuLiwei ZhaoJonathan PolSarah LevesqueAdriana PetrazzuoloChristina PfirschkeCamilla EngblomSteffen RickeltTakahiro YamazakiKristina IribarrenLaura SenovillaLucillia BezuErika VacchelliValentina SicaAndréa MelisTiffany MartinLin XiaHeng YangQingqing LiJinfeng ChenSylvère DurandFanny AprahamianDeborah LefevreSophie BroutinAngelo PaciAmaury BongersVeronique Minard-ColinEric TartourLaurence ZitvogelLionel ApetohYuting MaMikael J. PittetOliver KeppGuido KroemerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Peng Liu Liwei Zhao Jonathan Pol Sarah Levesque Adriana Petrazzuolo Christina Pfirschke Camilla Engblom Steffen Rickelt Takahiro Yamazaki Kristina Iribarren Laura Senovilla Lucillia Bezu Erika Vacchelli Valentina Sica Andréa Melis Tiffany Martin Lin Xia Heng Yang Qingqing Li Jinfeng Chen Sylvère Durand Fanny Aprahamian Deborah Lefevre Sophie Broutin Angelo Paci Amaury Bongers Veronique Minard-Colin Eric Tartour Laurence Zitvogel Lionel Apetoh Yuting Ma Mikael J. Pittet Oliver Kepp Guido Kroemer Crizotinib-induced immunogenic cell death in non-small cell lung cancer
description	Certain chemotherapeutic agents can exert their anticancer effect through indirect immune-dependent mechanism. Here, the authors screen a library of tyrosine kinase inhibitors and show that crizotinib is an effective stimulator of immunogenic cell death and can potentiate the efficacy of immune checkpoint blockade.
format	article
author	Peng Liu Liwei Zhao Jonathan Pol Sarah Levesque Adriana Petrazzuolo Christina Pfirschke Camilla Engblom Steffen Rickelt Takahiro Yamazaki Kristina Iribarren Laura Senovilla Lucillia Bezu Erika Vacchelli Valentina Sica Andréa Melis Tiffany Martin Lin Xia Heng Yang Qingqing Li Jinfeng Chen Sylvère Durand Fanny Aprahamian Deborah Lefevre Sophie Broutin Angelo Paci Amaury Bongers Veronique Minard-Colin Eric Tartour Laurence Zitvogel Lionel Apetoh Yuting Ma Mikael J. Pittet Oliver Kepp Guido Kroemer
author_facet	Peng Liu Liwei Zhao Jonathan Pol Sarah Levesque Adriana Petrazzuolo Christina Pfirschke Camilla Engblom Steffen Rickelt Takahiro Yamazaki Kristina Iribarren Laura Senovilla Lucillia Bezu Erika Vacchelli Valentina Sica Andréa Melis Tiffany Martin Lin Xia Heng Yang Qingqing Li Jinfeng Chen Sylvère Durand Fanny Aprahamian Deborah Lefevre Sophie Broutin Angelo Paci Amaury Bongers Veronique Minard-Colin Eric Tartour Laurence Zitvogel Lionel Apetoh Yuting Ma Mikael J. Pittet Oliver Kepp Guido Kroemer
author_sort	Peng Liu
title	Crizotinib-induced immunogenic cell death in non-small cell lung cancer
title_short	Crizotinib-induced immunogenic cell death in non-small cell lung cancer
title_full	Crizotinib-induced immunogenic cell death in non-small cell lung cancer
title_fullStr	Crizotinib-induced immunogenic cell death in non-small cell lung cancer
title_full_unstemmed	Crizotinib-induced immunogenic cell death in non-small cell lung cancer
title_sort	crizotinib-induced immunogenic cell death in non-small cell lung cancer
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/228ee56caf814e7fbcca341ed093aaed
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Crizotinib-induced immunogenic cell death in non-small cell lung cancer

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