Nanoparticle-based model of anti-inflammatory drug releasing LbL coatings for uncemented prosthesis aseptic loosening prevention

Hadil Faris Alotaibi, Stefano Perni, Polina Prokopovich School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff, UKCorrespondence: Polina ProkopovichSchool of Pharmacy and Pharmaceutical Sciences, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff CF10 3NB, UKT...

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Autores principales:	Alotaibi HF, Perni S, Prokopovich P
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	titanium cementless prosthesis aseptic loosening dexamethasone Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/228f22f1fe384b84807cdc394a792c5e
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spelling	oai:doaj.org-article:228f22f1fe384b84807cdc394a792c5e2021-12-02T08:22:01ZNanoparticle-based model of anti-inflammatory drug releasing LbL coatings for uncemented prosthesis aseptic loosening prevention1178-2013https://doaj.org/article/228f22f1fe384b84807cdc394a792c5e2019-09-01T00:00:00Zhttps://www.dovepress.com/nanoparticle-based-model-of-anti-inflammatory-drug-releasing-lbl-coati-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Hadil Faris Alotaibi, Stefano Perni, Polina Prokopovich School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff, UKCorrespondence: Polina ProkopovichSchool of Pharmacy and Pharmaceutical Sciences, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff CF10 3NB, UKTel +44 29 208 75820Fax +44 29 208 74149Email prokopovichp@cardiff.ac.ukIntroduction: The only treatment for aseptic loosening is the replacement of the prosthesis through revision surgery. A preventive approach, achieved through anti-inflammatory drugs released from the device, has shown to be a viable strategy; however, the performance of these devices is not yet satisfactory thus further improvements are necessary.Methods: We used titanium nanoparticles as a model for implant surfaces and developed a coating containing dexamethasone (DEX) using layer-by-layer deposition.Results: The amount of deposited drug depended on the number of layers and the release was sustained for months. The efficiency of the released DEX in reducing inflammation markers (tumor necrosis factor alpha and IL-6) produced by human monocytes and macrophages was similar to the pure drug at the same concentration without negative impacts on the viability and morphology of these cells.Conclusion: These coatings were not inferior to medical grade titanium (the standard material used in uncemented devices) regarding their ability to sustain osteoblasts and fibroblasts growth.Keywords: titanium, cementless prosthesis, aseptic loosening, dexamethasoneAlotaibi HFPerni SProkopovich PDove Medical Pressarticletitaniumcementless prosthesisaseptic looseningdexamethasoneMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 7309-7322 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	titanium cementless prosthesis aseptic loosening dexamethasone Medicine (General) R5-920
spellingShingle	titanium cementless prosthesis aseptic loosening dexamethasone Medicine (General) R5-920 Alotaibi HF Perni S Prokopovich P Nanoparticle-based model of anti-inflammatory drug releasing LbL coatings for uncemented prosthesis aseptic loosening prevention
description	Hadil Faris Alotaibi, Stefano Perni, Polina Prokopovich School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff, UKCorrespondence: Polina ProkopovichSchool of Pharmacy and Pharmaceutical Sciences, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff CF10 3NB, UKTel +44 29 208 75820Fax +44 29 208 74149Email prokopovichp@cardiff.ac.ukIntroduction: The only treatment for aseptic loosening is the replacement of the prosthesis through revision surgery. A preventive approach, achieved through anti-inflammatory drugs released from the device, has shown to be a viable strategy; however, the performance of these devices is not yet satisfactory thus further improvements are necessary.Methods: We used titanium nanoparticles as a model for implant surfaces and developed a coating containing dexamethasone (DEX) using layer-by-layer deposition.Results: The amount of deposited drug depended on the number of layers and the release was sustained for months. The efficiency of the released DEX in reducing inflammation markers (tumor necrosis factor alpha and IL-6) produced by human monocytes and macrophages was similar to the pure drug at the same concentration without negative impacts on the viability and morphology of these cells.Conclusion: These coatings were not inferior to medical grade titanium (the standard material used in uncemented devices) regarding their ability to sustain osteoblasts and fibroblasts growth.Keywords: titanium, cementless prosthesis, aseptic loosening, dexamethasone
format	article
author	Alotaibi HF Perni S Prokopovich P
author_facet	Alotaibi HF Perni S Prokopovich P
author_sort	Alotaibi HF
title	Nanoparticle-based model of anti-inflammatory drug releasing LbL coatings for uncemented prosthesis aseptic loosening prevention
title_short	Nanoparticle-based model of anti-inflammatory drug releasing LbL coatings for uncemented prosthesis aseptic loosening prevention
title_full	Nanoparticle-based model of anti-inflammatory drug releasing LbL coatings for uncemented prosthesis aseptic loosening prevention
title_fullStr	Nanoparticle-based model of anti-inflammatory drug releasing LbL coatings for uncemented prosthesis aseptic loosening prevention
title_full_unstemmed	Nanoparticle-based model of anti-inflammatory drug releasing LbL coatings for uncemented prosthesis aseptic loosening prevention
title_sort	nanoparticle-based model of anti-inflammatory drug releasing lbl coatings for uncemented prosthesis aseptic loosening prevention
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/228f22f1fe384b84807cdc394a792c5e
work_keys_str_mv	AT alotaibihf nanoparticlebasedmodelofantiinflammatorydrugreleasinglblcoatingsforuncementedprosthesisasepticlooseningprevention AT pernis nanoparticlebasedmodelofantiinflammatorydrugreleasinglblcoatingsforuncementedprosthesisasepticlooseningprevention AT prokopovichp nanoparticlebasedmodelofantiinflammatorydrugreleasinglblcoatingsforuncementedprosthesisasepticlooseningprevention
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Nanoparticle-based model of anti-inflammatory drug releasing LbL coatings for uncemented prosthesis aseptic loosening prevention

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