Engineering a microbial biosynthesis platform for de novo production of tropane alkaloids

Tropane alkaloids (TAs) are a group of phytochemicals that are used to treat neurological disorders. Here, the authors engineer baker’s yeast to produce tropine, a key intermediate in the biosynthetic pathway of TAs, and cinnamoyltropine, a non-canonical TA, from simple carbon and nitrogen sources....

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Autores principales:	Prashanth Srinivasan, Christina D. Smolke
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/228fb2896bb7466ebf6688fcfa91ede9
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spelling	oai:doaj.org-article:228fb2896bb7466ebf6688fcfa91ede92021-12-02T15:36:22ZEngineering a microbial biosynthesis platform for de novo production of tropane alkaloids10.1038/s41467-019-11588-w2041-1723https://doaj.org/article/228fb2896bb7466ebf6688fcfa91ede92019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11588-whttps://doaj.org/toc/2041-1723Tropane alkaloids (TAs) are a group of phytochemicals that are used to treat neurological disorders. Here, the authors engineer baker’s yeast to produce tropine, a key intermediate in the biosynthetic pathway of TAs, and cinnamoyltropine, a non-canonical TA, from simple carbon and nitrogen sources.Prashanth SrinivasanChristina D. SmolkeNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Prashanth Srinivasan Christina D. Smolke Engineering a microbial biosynthesis platform for de novo production of tropane alkaloids
description	Tropane alkaloids (TAs) are a group of phytochemicals that are used to treat neurological disorders. Here, the authors engineer baker’s yeast to produce tropine, a key intermediate in the biosynthetic pathway of TAs, and cinnamoyltropine, a non-canonical TA, from simple carbon and nitrogen sources.
format	article
author	Prashanth Srinivasan Christina D. Smolke
author_facet	Prashanth Srinivasan Christina D. Smolke
author_sort	Prashanth Srinivasan
title	Engineering a microbial biosynthesis platform for de novo production of tropane alkaloids
title_short	Engineering a microbial biosynthesis platform for de novo production of tropane alkaloids
title_full	Engineering a microbial biosynthesis platform for de novo production of tropane alkaloids
title_fullStr	Engineering a microbial biosynthesis platform for de novo production of tropane alkaloids
title_full_unstemmed	Engineering a microbial biosynthesis platform for de novo production of tropane alkaloids
title_sort	engineering a microbial biosynthesis platform for de novo production of tropane alkaloids
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/228fb2896bb7466ebf6688fcfa91ede9
work_keys_str_mv	AT prashanthsrinivasan engineeringamicrobialbiosynthesisplatformfordenovoproductionoftropanealkaloids AT christinadsmolke engineeringamicrobialbiosynthesisplatformfordenovoproductionoftropanealkaloids
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Engineering a microbial biosynthesis platform for de novo production of tropane alkaloids

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