The influence of marital status on survival of gallbladder cancer patients: a population-based study

Abstract Marital status has been found to be a prognostic factor for survival in various cancers, but its role in gallbladder cancer (GBC) has not been fully studied. In this study, we used the Surveillance, Epidemiology, and End Results Program (SEER)-registered database to analyze the survival of...

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Autores principales:	Xinxing Li, Ye Liu, Yi Wang, Canping Ruan, Haolu Wang, Xiaowen Liang, Yanping Sun, Zhiqian Hu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/229010c95eaf407abc87af5226c3e8eb
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spelling	oai:doaj.org-article:229010c95eaf407abc87af5226c3e8eb2021-12-02T15:06:00ZThe influence of marital status on survival of gallbladder cancer patients: a population-based study10.1038/s41598-017-05545-02045-2322https://doaj.org/article/229010c95eaf407abc87af5226c3e8eb2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05545-0https://doaj.org/toc/2045-2322Abstract Marital status has been found to be a prognostic factor for survival in various cancers, but its role in gallbladder cancer (GBC) has not been fully studied. In this study, we used the Surveillance, Epidemiology, and End Results Program (SEER)-registered database to analyze the survival of GBC patients with different marital status. A total of 6,627 GBC patients were selected from SEER database from 2004 to 2013. The age, race, grade, histologic type, AJCC stage, SEER stage and marital status were identified as independent prognostic factors. Married GBC patients had a higher 5-year cancer-specific survival (CSS) than that of unmarried ones (20.1% v.s. 17.8%, P < 0.05). Subgroup analyses showed that widowed patients had 14.0% less of 5-year CSS compared to married ones of stage I (55.9% v.s. 41.9%, P < 0.05), 14.7% of stage II (15.6% v.s. 10.9%, P < 0.05), and 1.5% of stage III + IV (2.9% v.s. 1.4%, P < 0.05). In addition, single is an independent prognostic factor at stage III + IV (HR = 1.225, 95%CI 1.054–1.423, P = 0.008). These results indicated that widowed patients were at a high risk of cancer-specific mortality and marriage can be a protective prognostic factor in CSS.Xinxing LiYe LiuYi WangCanping RuanHaolu WangXiaowen LiangYanping SunZhiqian HuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xinxing Li Ye Liu Yi Wang Canping Ruan Haolu Wang Xiaowen Liang Yanping Sun Zhiqian Hu The influence of marital status on survival of gallbladder cancer patients: a population-based study
description	Abstract Marital status has been found to be a prognostic factor for survival in various cancers, but its role in gallbladder cancer (GBC) has not been fully studied. In this study, we used the Surveillance, Epidemiology, and End Results Program (SEER)-registered database to analyze the survival of GBC patients with different marital status. A total of 6,627 GBC patients were selected from SEER database from 2004 to 2013. The age, race, grade, histologic type, AJCC stage, SEER stage and marital status were identified as independent prognostic factors. Married GBC patients had a higher 5-year cancer-specific survival (CSS) than that of unmarried ones (20.1% v.s. 17.8%, P < 0.05). Subgroup analyses showed that widowed patients had 14.0% less of 5-year CSS compared to married ones of stage I (55.9% v.s. 41.9%, P < 0.05), 14.7% of stage II (15.6% v.s. 10.9%, P < 0.05), and 1.5% of stage III + IV (2.9% v.s. 1.4%, P < 0.05). In addition, single is an independent prognostic factor at stage III + IV (HR = 1.225, 95%CI 1.054–1.423, P = 0.008). These results indicated that widowed patients were at a high risk of cancer-specific mortality and marriage can be a protective prognostic factor in CSS.
format	article
author	Xinxing Li Ye Liu Yi Wang Canping Ruan Haolu Wang Xiaowen Liang Yanping Sun Zhiqian Hu
author_facet	Xinxing Li Ye Liu Yi Wang Canping Ruan Haolu Wang Xiaowen Liang Yanping Sun Zhiqian Hu
author_sort	Xinxing Li
title	The influence of marital status on survival of gallbladder cancer patients: a population-based study
title_short	The influence of marital status on survival of gallbladder cancer patients: a population-based study
title_full	The influence of marital status on survival of gallbladder cancer patients: a population-based study
title_fullStr	The influence of marital status on survival of gallbladder cancer patients: a population-based study
title_full_unstemmed	The influence of marital status on survival of gallbladder cancer patients: a population-based study
title_sort	influence of marital status on survival of gallbladder cancer patients: a population-based study
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/229010c95eaf407abc87af5226c3e8eb
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The influence of marital status on survival of gallbladder cancer patients: a population-based study

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