CTLA-4 expression by B-1a B cells is essential for immune tolerance
CTLA-4 is an important co-inhibitory receptor for T cells. Here, the authors show that CTLA-4 also has a function on B-1a cells, as conditional deletion results in activation of these cells and knockout mice develop an autoimmune profile.
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Nature Portfolio
2021
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| Acceso en línea: | https://doaj.org/article/229a32c1fd3d4c71969347ac1499f7d4 |
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oai:doaj.org-article:229a32c1fd3d4c71969347ac1499f7d42021-12-02T10:49:14ZCTLA-4 expression by B-1a B cells is essential for immune tolerance10.1038/s41467-020-20874-x2041-1723https://doaj.org/article/229a32c1fd3d4c71969347ac1499f7d42021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20874-xhttps://doaj.org/toc/2041-1723CTLA-4 is an important co-inhibitory receptor for T cells. Here, the authors show that CTLA-4 also has a function on B-1a cells, as conditional deletion results in activation of these cells and knockout mice develop an autoimmune profile.Yang YangXiao LiZhihai MaChunlin WangQunying YangMiranda Byrne-SteeleRongjian HongQing MinGao ZhouYong ChengGuang QinJustin V. YoungyunpipatkulJames B. WingShimon SakaguchiChristian ToonstraLai-Xi WangJose G. Vilches-MoureDenong WangMichael P. SnyderJi-Yang WangJian HanLeonore A. HerzenbergNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Yang Yang Xiao Li Zhihai Ma Chunlin Wang Qunying Yang Miranda Byrne-Steele Rongjian Hong Qing Min Gao Zhou Yong Cheng Guang Qin Justin V. Youngyunpipatkul James B. Wing Shimon Sakaguchi Christian Toonstra Lai-Xi Wang Jose G. Vilches-Moure Denong Wang Michael P. Snyder Ji-Yang Wang Jian Han Leonore A. Herzenberg CTLA-4 expression by B-1a B cells is essential for immune tolerance |
| description |
CTLA-4 is an important co-inhibitory receptor for T cells. Here, the authors show that CTLA-4 also has a function on B-1a cells, as conditional deletion results in activation of these cells and knockout mice develop an autoimmune profile. |
| format |
article |
| author |
Yang Yang Xiao Li Zhihai Ma Chunlin Wang Qunying Yang Miranda Byrne-Steele Rongjian Hong Qing Min Gao Zhou Yong Cheng Guang Qin Justin V. Youngyunpipatkul James B. Wing Shimon Sakaguchi Christian Toonstra Lai-Xi Wang Jose G. Vilches-Moure Denong Wang Michael P. Snyder Ji-Yang Wang Jian Han Leonore A. Herzenberg |
| author_facet |
Yang Yang Xiao Li Zhihai Ma Chunlin Wang Qunying Yang Miranda Byrne-Steele Rongjian Hong Qing Min Gao Zhou Yong Cheng Guang Qin Justin V. Youngyunpipatkul James B. Wing Shimon Sakaguchi Christian Toonstra Lai-Xi Wang Jose G. Vilches-Moure Denong Wang Michael P. Snyder Ji-Yang Wang Jian Han Leonore A. Herzenberg |
| author_sort |
Yang Yang |
| title |
CTLA-4 expression by B-1a B cells is essential for immune tolerance |
| title_short |
CTLA-4 expression by B-1a B cells is essential for immune tolerance |
| title_full |
CTLA-4 expression by B-1a B cells is essential for immune tolerance |
| title_fullStr |
CTLA-4 expression by B-1a B cells is essential for immune tolerance |
| title_full_unstemmed |
CTLA-4 expression by B-1a B cells is essential for immune tolerance |
| title_sort |
ctla-4 expression by b-1a b cells is essential for immune tolerance |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/229a32c1fd3d4c71969347ac1499f7d4 |
| work_keys_str_mv |
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