Characterization of an engineered live bacterial therapeutic for the treatment of phenylketonuria in a human gut-on-a-chip

Engineered live bacteria could represent a new class of therapeutic treatment for human disease. Here, the authors use a human gut-on-a-chip microfluidics system to characterize an engineered live bacterial therapeutic, designed for the treatment of phenylketonuria, and to construct mathematical mod...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	M. Tyler Nelson, Mark R. Charbonneau, Heidi G. Coia, Mary J. Castillo, Corey Holt, Eric S. Greenwood, Peter J. Robinson, Elaine A. Merrill, David Lubkowicz, Camilla A. Mauzy
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/229bd7533d5f4591b5fea3903111b0fd
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:229bd7533d5f4591b5fea3903111b0fd
record_format	dspace
spelling	oai:doaj.org-article:229bd7533d5f4591b5fea3903111b0fd2021-12-02T15:43:16ZCharacterization of an engineered live bacterial therapeutic for the treatment of phenylketonuria in a human gut-on-a-chip10.1038/s41467-021-23072-52041-1723https://doaj.org/article/229bd7533d5f4591b5fea3903111b0fd2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23072-5https://doaj.org/toc/2041-1723Engineered live bacteria could represent a new class of therapeutic treatment for human disease. Here, the authors use a human gut-on-a-chip microfluidics system to characterize an engineered live bacterial therapeutic, designed for the treatment of phenylketonuria, and to construct mathematical models that predict therapeutic strain function in non-human primates.M. Tyler NelsonMark R. CharbonneauHeidi G. CoiaMary J. CastilloCorey HoltEric S. GreenwoodPeter J. RobinsonElaine A. MerrillDavid LubkowiczCamilla A. MauzyNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q M. Tyler Nelson Mark R. Charbonneau Heidi G. Coia Mary J. Castillo Corey Holt Eric S. Greenwood Peter J. Robinson Elaine A. Merrill David Lubkowicz Camilla A. Mauzy Characterization of an engineered live bacterial therapeutic for the treatment of phenylketonuria in a human gut-on-a-chip
description	Engineered live bacteria could represent a new class of therapeutic treatment for human disease. Here, the authors use a human gut-on-a-chip microfluidics system to characterize an engineered live bacterial therapeutic, designed for the treatment of phenylketonuria, and to construct mathematical models that predict therapeutic strain function in non-human primates.
format	article
author	M. Tyler Nelson Mark R. Charbonneau Heidi G. Coia Mary J. Castillo Corey Holt Eric S. Greenwood Peter J. Robinson Elaine A. Merrill David Lubkowicz Camilla A. Mauzy
author_facet	M. Tyler Nelson Mark R. Charbonneau Heidi G. Coia Mary J. Castillo Corey Holt Eric S. Greenwood Peter J. Robinson Elaine A. Merrill David Lubkowicz Camilla A. Mauzy
author_sort	M. Tyler Nelson
title	Characterization of an engineered live bacterial therapeutic for the treatment of phenylketonuria in a human gut-on-a-chip
title_short	Characterization of an engineered live bacterial therapeutic for the treatment of phenylketonuria in a human gut-on-a-chip
title_full	Characterization of an engineered live bacterial therapeutic for the treatment of phenylketonuria in a human gut-on-a-chip
title_fullStr	Characterization of an engineered live bacterial therapeutic for the treatment of phenylketonuria in a human gut-on-a-chip
title_full_unstemmed	Characterization of an engineered live bacterial therapeutic for the treatment of phenylketonuria in a human gut-on-a-chip
title_sort	characterization of an engineered live bacterial therapeutic for the treatment of phenylketonuria in a human gut-on-a-chip
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/229bd7533d5f4591b5fea3903111b0fd
work_keys_str_mv	AT mtylernelson characterizationofanengineeredlivebacterialtherapeuticforthetreatmentofphenylketonuriainahumangutonachip AT markrcharbonneau characterizationofanengineeredlivebacterialtherapeuticforthetreatmentofphenylketonuriainahumangutonachip AT heidigcoia characterizationofanengineeredlivebacterialtherapeuticforthetreatmentofphenylketonuriainahumangutonachip AT maryjcastillo characterizationofanengineeredlivebacterialtherapeuticforthetreatmentofphenylketonuriainahumangutonachip AT coreyholt characterizationofanengineeredlivebacterialtherapeuticforthetreatmentofphenylketonuriainahumangutonachip AT ericsgreenwood characterizationofanengineeredlivebacterialtherapeuticforthetreatmentofphenylketonuriainahumangutonachip AT peterjrobinson characterizationofanengineeredlivebacterialtherapeuticforthetreatmentofphenylketonuriainahumangutonachip AT elaineamerrill characterizationofanengineeredlivebacterialtherapeuticforthetreatmentofphenylketonuriainahumangutonachip AT davidlubkowicz characterizationofanengineeredlivebacterialtherapeuticforthetreatmentofphenylketonuriainahumangutonachip AT camillaamauzy characterizationofanengineeredlivebacterialtherapeuticforthetreatmentofphenylketonuriainahumangutonachip
_version_	1718385797765267456

Characterization of an engineered live bacterial therapeutic for the treatment of phenylketonuria in a human gut-on-a-chip

Ejemplares similares