Electro-osmotic capture and ionic discrimination of peptide and protein biomarkers with FraC nanopores

Biological nanopore–based protein sequencing and recognition is challenging due to the folded structure or non-uniform charge of peptides. Here the authors show that engineered FraC nanopores can overcome these problems and recognize biomarkers in the form of oligopeptides, polypeptides and folded p...

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Autores principales:	Gang Huang, Kherim Willems, Misha Soskine, Carsten Wloka, Giovanni Maglia
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/229ceae5404f44ed83b8b5d44da50e41
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id	oai:doaj.org-article:229ceae5404f44ed83b8b5d44da50e41
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spelling	oai:doaj.org-article:229ceae5404f44ed83b8b5d44da50e412021-12-02T14:42:20ZElectro-osmotic capture and ionic discrimination of peptide and protein biomarkers with FraC nanopores10.1038/s41467-017-01006-42041-1723https://doaj.org/article/229ceae5404f44ed83b8b5d44da50e412017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01006-4https://doaj.org/toc/2041-1723Biological nanopore–based protein sequencing and recognition is challenging due to the folded structure or non-uniform charge of peptides. Here the authors show that engineered FraC nanopores can overcome these problems and recognize biomarkers in the form of oligopeptides, polypeptides and folded proteins.Gang HuangKherim WillemsMisha SoskineCarsten WlokaGiovanni MagliaNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gang Huang Kherim Willems Misha Soskine Carsten Wloka Giovanni Maglia Electro-osmotic capture and ionic discrimination of peptide and protein biomarkers with FraC nanopores
description	Biological nanopore–based protein sequencing and recognition is challenging due to the folded structure or non-uniform charge of peptides. Here the authors show that engineered FraC nanopores can overcome these problems and recognize biomarkers in the form of oligopeptides, polypeptides and folded proteins.
format	article
author	Gang Huang Kherim Willems Misha Soskine Carsten Wloka Giovanni Maglia
author_facet	Gang Huang Kherim Willems Misha Soskine Carsten Wloka Giovanni Maglia
author_sort	Gang Huang
title	Electro-osmotic capture and ionic discrimination of peptide and protein biomarkers with FraC nanopores
title_short	Electro-osmotic capture and ionic discrimination of peptide and protein biomarkers with FraC nanopores
title_full	Electro-osmotic capture and ionic discrimination of peptide and protein biomarkers with FraC nanopores
title_fullStr	Electro-osmotic capture and ionic discrimination of peptide and protein biomarkers with FraC nanopores
title_full_unstemmed	Electro-osmotic capture and ionic discrimination of peptide and protein biomarkers with FraC nanopores
title_sort	electro-osmotic capture and ionic discrimination of peptide and protein biomarkers with frac nanopores
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/229ceae5404f44ed83b8b5d44da50e41
work_keys_str_mv	AT ganghuang electroosmoticcaptureandionicdiscriminationofpeptideandproteinbiomarkerswithfracnanopores AT kherimwillems electroosmoticcaptureandionicdiscriminationofpeptideandproteinbiomarkerswithfracnanopores AT mishasoskine electroosmoticcaptureandionicdiscriminationofpeptideandproteinbiomarkerswithfracnanopores AT carstenwloka electroosmoticcaptureandionicdiscriminationofpeptideandproteinbiomarkerswithfracnanopores AT giovannimaglia electroosmoticcaptureandionicdiscriminationofpeptideandproteinbiomarkerswithfracnanopores
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Electro-osmotic capture and ionic discrimination of peptide and protein biomarkers with FraC nanopores

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