The transcriptional regulator ZNF398 mediates pluripotency and epithelial character downstream of TGF-beta in human PSCs

The transcriptional regulator ZNF398 mediates pluripotency and epithelial character downstream of TGF-beta in human PSCs

The downstream pathway regulating how TGF-beta affects pluripotency of human PSCs is unclear. Here, the authors find that transcription factor ZNF398 binds active promoters/enhancers together with the histone acetyltransferase EP300 and SMAD3, enabling expression of pluripotency and epithelial genes...

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Autores principales: Irene Zorzan, Marco Pellegrini, Mattia Arboit, Danny Incarnato, Mara Maldotti, Mattia Forcato, Guidantonio Malagoli Tagliazucchi, Elena Carbognin, Marco Montagner, Salvatore Oliviero, Graziano Martello
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/229d19576d604e2eaa019c9c5df632f1
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spelling oai:doaj.org-article:229d19576d604e2eaa019c9c5df632f12021-12-02T16:50:26ZThe transcriptional regulator ZNF398 mediates pluripotency and epithelial character downstream of TGF-beta in human PSCs10.1038/s41467-020-16205-92041-1723https://doaj.org/article/229d19576d604e2eaa019c9c5df632f12020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16205-9https://doaj.org/toc/2041-1723The downstream pathway regulating how TGF-beta affects pluripotency of human PSCs is unclear. Here, the authors find that transcription factor ZNF398 binds active promoters/enhancers together with the histone acetyltransferase EP300 and SMAD3, enabling expression of pluripotency and epithelial genes.Irene ZorzanMarco PellegriniMattia ArboitDanny IncarnatoMara MaldottiMattia ForcatoGuidantonio Malagoli TagliazucchiElena CarbogninMarco MontagnerSalvatore OlivieroGraziano MartelloNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Irene Zorzan
Marco Pellegrini
Mattia Arboit
Danny Incarnato
Mara Maldotti
Mattia Forcato
Guidantonio Malagoli Tagliazucchi
Elena Carbognin
Marco Montagner
Salvatore Oliviero
Graziano Martello
The transcriptional regulator ZNF398 mediates pluripotency and epithelial character downstream of TGF-beta in human PSCs
description The downstream pathway regulating how TGF-beta affects pluripotency of human PSCs is unclear. Here, the authors find that transcription factor ZNF398 binds active promoters/enhancers together with the histone acetyltransferase EP300 and SMAD3, enabling expression of pluripotency and epithelial genes.
format article
author Irene Zorzan
Marco Pellegrini
Mattia Arboit
Danny Incarnato
Mara Maldotti
Mattia Forcato
Guidantonio Malagoli Tagliazucchi
Elena Carbognin
Marco Montagner
Salvatore Oliviero
Graziano Martello
author_facet Irene Zorzan
Marco Pellegrini
Mattia Arboit
Danny Incarnato
Mara Maldotti
Mattia Forcato
Guidantonio Malagoli Tagliazucchi
Elena Carbognin
Marco Montagner
Salvatore Oliviero
Graziano Martello
author_sort Irene Zorzan
title The transcriptional regulator ZNF398 mediates pluripotency and epithelial character downstream of TGF-beta in human PSCs
title_short The transcriptional regulator ZNF398 mediates pluripotency and epithelial character downstream of TGF-beta in human PSCs
title_full The transcriptional regulator ZNF398 mediates pluripotency and epithelial character downstream of TGF-beta in human PSCs
title_fullStr The transcriptional regulator ZNF398 mediates pluripotency and epithelial character downstream of TGF-beta in human PSCs
title_full_unstemmed The transcriptional regulator ZNF398 mediates pluripotency and epithelial character downstream of TGF-beta in human PSCs
title_sort transcriptional regulator znf398 mediates pluripotency and epithelial character downstream of tgf-beta in human pscs
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/229d19576d604e2eaa019c9c5df632f1
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