LipidII interaction with specific residues of Mycobacterium tuberculosis PknB extracytoplasmic domain governs its optimal activation

The Mycobacterium tuberculosis kinase PknB regulates essential cell functions via interactions with muropeptides. Here the authors identify interaction sites in the extracytoplasmic PASTA domain and show that abrogation of ligand binding leads to a hyper-activated kinase, causing loss of homeostasis...

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Autores principales:	Prabhjot Kaur, Marvin Rausch, Basanti Malakar, Uchenna Watson, Nikhil P. Damle, Yogesh Chawla, Sandhya Srinivasan, Kanika Sharma, Tanja Schneider, Gagan Deep Jhingan, Deepak Saini, Debasisa Mohanty, Fabian Grein, Vinay Kumar Nandicoori
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/229dcd6f9fca48209698162286590a15
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spelling	oai:doaj.org-article:229dcd6f9fca48209698162286590a152021-12-02T16:57:53ZLipidII interaction with specific residues of Mycobacterium tuberculosis PknB extracytoplasmic domain governs its optimal activation10.1038/s41467-019-09223-92041-1723https://doaj.org/article/229dcd6f9fca48209698162286590a152019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09223-9https://doaj.org/toc/2041-1723The Mycobacterium tuberculosis kinase PknB regulates essential cell functions via interactions with muropeptides. Here the authors identify interaction sites in the extracytoplasmic PASTA domain and show that abrogation of ligand binding leads to a hyper-activated kinase, causing loss of homeostasis and cell death.Prabhjot KaurMarvin RauschBasanti MalakarUchenna WatsonNikhil P. DamleYogesh ChawlaSandhya SrinivasanKanika SharmaTanja SchneiderGagan Deep JhinganDeepak SainiDebasisa MohantyFabian GreinVinay Kumar NandicooriNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Prabhjot Kaur Marvin Rausch Basanti Malakar Uchenna Watson Nikhil P. Damle Yogesh Chawla Sandhya Srinivasan Kanika Sharma Tanja Schneider Gagan Deep Jhingan Deepak Saini Debasisa Mohanty Fabian Grein Vinay Kumar Nandicoori LipidII interaction with specific residues of Mycobacterium tuberculosis PknB extracytoplasmic domain governs its optimal activation
description	The Mycobacterium tuberculosis kinase PknB regulates essential cell functions via interactions with muropeptides. Here the authors identify interaction sites in the extracytoplasmic PASTA domain and show that abrogation of ligand binding leads to a hyper-activated kinase, causing loss of homeostasis and cell death.
format	article
author	Prabhjot Kaur Marvin Rausch Basanti Malakar Uchenna Watson Nikhil P. Damle Yogesh Chawla Sandhya Srinivasan Kanika Sharma Tanja Schneider Gagan Deep Jhingan Deepak Saini Debasisa Mohanty Fabian Grein Vinay Kumar Nandicoori
author_facet	Prabhjot Kaur Marvin Rausch Basanti Malakar Uchenna Watson Nikhil P. Damle Yogesh Chawla Sandhya Srinivasan Kanika Sharma Tanja Schneider Gagan Deep Jhingan Deepak Saini Debasisa Mohanty Fabian Grein Vinay Kumar Nandicoori
author_sort	Prabhjot Kaur
title	LipidII interaction with specific residues of Mycobacterium tuberculosis PknB extracytoplasmic domain governs its optimal activation
title_short	LipidII interaction with specific residues of Mycobacterium tuberculosis PknB extracytoplasmic domain governs its optimal activation
title_full	LipidII interaction with specific residues of Mycobacterium tuberculosis PknB extracytoplasmic domain governs its optimal activation
title_fullStr	LipidII interaction with specific residues of Mycobacterium tuberculosis PknB extracytoplasmic domain governs its optimal activation
title_full_unstemmed	LipidII interaction with specific residues of Mycobacterium tuberculosis PknB extracytoplasmic domain governs its optimal activation
title_sort	lipidii interaction with specific residues of mycobacterium tuberculosis pknb extracytoplasmic domain governs its optimal activation
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/229dcd6f9fca48209698162286590a15
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LipidII interaction with specific residues of Mycobacterium tuberculosis PknB extracytoplasmic domain governs its optimal activation

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