Phase and power modulations on the amplitude of TMS-induced motor evoked potentials.

The evaluation of transcranial magnetic stimulation (TMS)-induced motor evoked potentials (MEPs) promises valuable information about fundamental brain related mechanisms and may serve as a diagnostic tool for clinical monitoring of therapeutic progress or surgery procedures. However, reports about s...

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Autores principales:	Lukas Schilberg, Sanne Ten Oever, Teresa Schuhmann, Alexander T Sack
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/22a21cf381e94e8298bbe60446f964cb
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spelling	oai:doaj.org-article:22a21cf381e94e8298bbe60446f964cb2021-12-02T20:08:13ZPhase and power modulations on the amplitude of TMS-induced motor evoked potentials.1932-620310.1371/journal.pone.0255815https://doaj.org/article/22a21cf381e94e8298bbe60446f964cb2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0255815https://doaj.org/toc/1932-6203The evaluation of transcranial magnetic stimulation (TMS)-induced motor evoked potentials (MEPs) promises valuable information about fundamental brain related mechanisms and may serve as a diagnostic tool for clinical monitoring of therapeutic progress or surgery procedures. However, reports about spontaneous fluctuations of MEP amplitudes causing high intra-individual variability have led to increased concerns about the reliability of this measure. One possible cause for high variability of MEPs could be neuronal oscillatory activity, which reflects fluctuations of membrane potentials that systematically increase and decrease the excitability of neuronal networks. Here, we investigate the dependence of MEP amplitude on oscillation power and phase by combining the application of single pulse TMS over the primary motor cortex with concurrent recordings of electromyography and electroencephalography. Our results show that MEP amplitude is correlated to alpha phase, alpha power as well as beta phase. These findings may help explain corticospinal excitability fluctuations by highlighting the modulatory effect of alpha and beta phase on MEPs. In the future, controlling for such a causal relationship may allow for the development of new protocols, improve this method as a (diagnostic) tool and increase the specificity and efficacy of general TMS applications.Lukas SchilbergSanne Ten OeverTeresa SchuhmannAlexander T SackPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 9, p e0255815 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lukas Schilberg Sanne Ten Oever Teresa Schuhmann Alexander T Sack Phase and power modulations on the amplitude of TMS-induced motor evoked potentials.
description	The evaluation of transcranial magnetic stimulation (TMS)-induced motor evoked potentials (MEPs) promises valuable information about fundamental brain related mechanisms and may serve as a diagnostic tool for clinical monitoring of therapeutic progress or surgery procedures. However, reports about spontaneous fluctuations of MEP amplitudes causing high intra-individual variability have led to increased concerns about the reliability of this measure. One possible cause for high variability of MEPs could be neuronal oscillatory activity, which reflects fluctuations of membrane potentials that systematically increase and decrease the excitability of neuronal networks. Here, we investigate the dependence of MEP amplitude on oscillation power and phase by combining the application of single pulse TMS over the primary motor cortex with concurrent recordings of electromyography and electroencephalography. Our results show that MEP amplitude is correlated to alpha phase, alpha power as well as beta phase. These findings may help explain corticospinal excitability fluctuations by highlighting the modulatory effect of alpha and beta phase on MEPs. In the future, controlling for such a causal relationship may allow for the development of new protocols, improve this method as a (diagnostic) tool and increase the specificity and efficacy of general TMS applications.
format	article
author	Lukas Schilberg Sanne Ten Oever Teresa Schuhmann Alexander T Sack
author_facet	Lukas Schilberg Sanne Ten Oever Teresa Schuhmann Alexander T Sack
author_sort	Lukas Schilberg
title	Phase and power modulations on the amplitude of TMS-induced motor evoked potentials.
title_short	Phase and power modulations on the amplitude of TMS-induced motor evoked potentials.
title_full	Phase and power modulations on the amplitude of TMS-induced motor evoked potentials.
title_fullStr	Phase and power modulations on the amplitude of TMS-induced motor evoked potentials.
title_full_unstemmed	Phase and power modulations on the amplitude of TMS-induced motor evoked potentials.
title_sort	phase and power modulations on the amplitude of tms-induced motor evoked potentials.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/22a21cf381e94e8298bbe60446f964cb
work_keys_str_mv	AT lukasschilberg phaseandpowermodulationsontheamplitudeoftmsinducedmotorevokedpotentials AT sannetenoever phaseandpowermodulationsontheamplitudeoftmsinducedmotorevokedpotentials AT teresaschuhmann phaseandpowermodulationsontheamplitudeoftmsinducedmotorevokedpotentials AT alexandertsack phaseandpowermodulationsontheamplitudeoftmsinducedmotorevokedpotentials
_version_	1718375168895614976

Phase and power modulations on the amplitude of TMS-induced motor evoked potentials.

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