Strand-specific single-cell methylomics reveals distinct modes of DNA demethylation dynamics during early mammalian development

Erasure of DNA methylation from the parental genomes is critical to reset the methylome of differentiated gametes to pluripotent cells in the blastocyst. Here, the authors present a high-throughput single-cell method that enables strand-specific quantification of DNA methylation and identify distinc...

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Autores principales:	Maya Sen, Dylan Mooijman, Alex Chialastri, Jean-Charles Boisset, Mina Popovic, Björn Heindryckx, Susana M. Chuva de Sousa Lopes, Siddharth S. Dey, Alexander van Oudenaarden
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/22a65134bcec4622ac372fd22140fe71
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spelling	oai:doaj.org-article:22a65134bcec4622ac372fd22140fe712021-12-02T13:14:48ZStrand-specific single-cell methylomics reveals distinct modes of DNA demethylation dynamics during early mammalian development10.1038/s41467-021-21532-62041-1723https://doaj.org/article/22a65134bcec4622ac372fd22140fe712021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21532-6https://doaj.org/toc/2041-1723Erasure of DNA methylation from the parental genomes is critical to reset the methylome of differentiated gametes to pluripotent cells in the blastocyst. Here, the authors present a high-throughput single-cell method that enables strand-specific quantification of DNA methylation and identify distinct modes of DNA demethylation dynamics during early mammalian development.Maya SenDylan MooijmanAlex ChialastriJean-Charles BoissetMina PopovicBjörn HeindryckxSusana M. Chuva de Sousa LopesSiddharth S. DeyAlexander van OudenaardenNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Maya Sen Dylan Mooijman Alex Chialastri Jean-Charles Boisset Mina Popovic Björn Heindryckx Susana M. Chuva de Sousa Lopes Siddharth S. Dey Alexander van Oudenaarden Strand-specific single-cell methylomics reveals distinct modes of DNA demethylation dynamics during early mammalian development
description	Erasure of DNA methylation from the parental genomes is critical to reset the methylome of differentiated gametes to pluripotent cells in the blastocyst. Here, the authors present a high-throughput single-cell method that enables strand-specific quantification of DNA methylation and identify distinct modes of DNA demethylation dynamics during early mammalian development.
format	article
author	Maya Sen Dylan Mooijman Alex Chialastri Jean-Charles Boisset Mina Popovic Björn Heindryckx Susana M. Chuva de Sousa Lopes Siddharth S. Dey Alexander van Oudenaarden
author_facet	Maya Sen Dylan Mooijman Alex Chialastri Jean-Charles Boisset Mina Popovic Björn Heindryckx Susana M. Chuva de Sousa Lopes Siddharth S. Dey Alexander van Oudenaarden
author_sort	Maya Sen
title	Strand-specific single-cell methylomics reveals distinct modes of DNA demethylation dynamics during early mammalian development
title_short	Strand-specific single-cell methylomics reveals distinct modes of DNA demethylation dynamics during early mammalian development
title_full	Strand-specific single-cell methylomics reveals distinct modes of DNA demethylation dynamics during early mammalian development
title_fullStr	Strand-specific single-cell methylomics reveals distinct modes of DNA demethylation dynamics during early mammalian development
title_full_unstemmed	Strand-specific single-cell methylomics reveals distinct modes of DNA demethylation dynamics during early mammalian development
title_sort	strand-specific single-cell methylomics reveals distinct modes of dna demethylation dynamics during early mammalian development
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/22a65134bcec4622ac372fd22140fe71
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Strand-specific single-cell methylomics reveals distinct modes of DNA demethylation dynamics during early mammalian development

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