Ubiquitin and TFIIH-stimulated DDB2 dissociation drives DNA damage handover in nucleotide excision repair

DNA damage sensors DDB2 and XPC are fundamental factors to initiate global genome nucleotide excision repair and protect DNA from mutagenesis. Here the authors reveal that ubiquitin and TFIIH-stimulated DDB2 dissociation promotes DNA damage handover to XPC in nucleotide excision repair.

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Auteurs principaux:	Cristina Ribeiro-Silva, Mariangela Sabatella, Angela Helfricht, Jurgen A. Marteijn, Arjan F. Theil, Wim Vermeulen, Hannes Lans
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2020
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/22a70086ef524db897815d6000e52c4e
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spelling	oai:doaj.org-article:22a70086ef524db897815d6000e52c4e2021-12-02T17:37:42ZUbiquitin and TFIIH-stimulated DDB2 dissociation drives DNA damage handover in nucleotide excision repair10.1038/s41467-020-18705-02041-1723https://doaj.org/article/22a70086ef524db897815d6000e52c4e2020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18705-0https://doaj.org/toc/2041-1723DNA damage sensors DDB2 and XPC are fundamental factors to initiate global genome nucleotide excision repair and protect DNA from mutagenesis. Here the authors reveal that ubiquitin and TFIIH-stimulated DDB2 dissociation promotes DNA damage handover to XPC in nucleotide excision repair.Cristina Ribeiro-SilvaMariangela SabatellaAngela HelfrichtJurgen A. MarteijnArjan F. TheilWim VermeulenHannes LansNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Cristina Ribeiro-Silva Mariangela Sabatella Angela Helfricht Jurgen A. Marteijn Arjan F. Theil Wim Vermeulen Hannes Lans Ubiquitin and TFIIH-stimulated DDB2 dissociation drives DNA damage handover in nucleotide excision repair
description	DNA damage sensors DDB2 and XPC are fundamental factors to initiate global genome nucleotide excision repair and protect DNA from mutagenesis. Here the authors reveal that ubiquitin and TFIIH-stimulated DDB2 dissociation promotes DNA damage handover to XPC in nucleotide excision repair.
format	article
author	Cristina Ribeiro-Silva Mariangela Sabatella Angela Helfricht Jurgen A. Marteijn Arjan F. Theil Wim Vermeulen Hannes Lans
author_facet	Cristina Ribeiro-Silva Mariangela Sabatella Angela Helfricht Jurgen A. Marteijn Arjan F. Theil Wim Vermeulen Hannes Lans
author_sort	Cristina Ribeiro-Silva
title	Ubiquitin and TFIIH-stimulated DDB2 dissociation drives DNA damage handover in nucleotide excision repair
title_short	Ubiquitin and TFIIH-stimulated DDB2 dissociation drives DNA damage handover in nucleotide excision repair
title_full	Ubiquitin and TFIIH-stimulated DDB2 dissociation drives DNA damage handover in nucleotide excision repair
title_fullStr	Ubiquitin and TFIIH-stimulated DDB2 dissociation drives DNA damage handover in nucleotide excision repair
title_full_unstemmed	Ubiquitin and TFIIH-stimulated DDB2 dissociation drives DNA damage handover in nucleotide excision repair
title_sort	ubiquitin and tfiih-stimulated ddb2 dissociation drives dna damage handover in nucleotide excision repair
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/22a70086ef524db897815d6000e52c4e
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Ubiquitin and TFIIH-stimulated DDB2 dissociation drives DNA damage handover in nucleotide excision repair

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