Case Report: Kampo Medicine for Non-tuberculous Mycobacterium Pulmonary Disease

Background: While the number of pulmonary tuberculosis cases has decreased, increase in non-tuberculous mycobacterium pulmonary disease (NTM-PD) is a global problem. Guideline-based therapy for NTM-PD sometimes causes complications that prevent treatment completion, and there are many cases of relap...

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Autores principales:	Tomoko Suzuki, Kazushi Uneda, Ryutaro Aoyagi, Takehito Kobayashi, Tadamichi Mitsuma, Hidetomo Nakamoto
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	non-tuberculous mycobacterium-pulmonary disease (NTM-PD) Kampo medicine hozai bukuryoshigyakuto hochuekkito Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/22aa3bc47926464d9648ffbdcda16e0e
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spelling	oai:doaj.org-article:22aa3bc47926464d9648ffbdcda16e0e2021-11-04T05:38:25ZCase Report: Kampo Medicine for Non-tuberculous Mycobacterium Pulmonary Disease2296-861X10.3389/fnut.2021.761934https://doaj.org/article/22aa3bc47926464d9648ffbdcda16e0e2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnut.2021.761934/fullhttps://doaj.org/toc/2296-861XBackground: While the number of pulmonary tuberculosis cases has decreased, increase in non-tuberculous mycobacterium pulmonary disease (NTM-PD) is a global problem. Guideline-based therapy for NTM-PD sometimes causes complications that prevent treatment completion, and there are many cases of relapse even if the treatment can be completed. In addition to antibacterial treatment, care of host risk factors, such as aging, lean physique and immunosuppressive state, is also very important for the management of NTM-PD. In Japan, Kampo medicine, a traditional Japanese herbal formulation, used alone or in combination with standard multidrug therapy for NTM-PD, has been found to be effective for such cases.Case Presentation: A 77-year-old lean woman had been diagnosed with Mycobacterium intracellulare pulmonary infection 6 years earlier, and had received the standard multidrug treatment 5 years later at a former hospital due to worsening of her symptoms of cough, breathlessness and hemoptysis. However, the treatment was discontinued within a year due to the development of adverse events. She refused the guideline-based antibacterial treatment, and asked for Kampo medicine instead. Bukuryoshigyakuto was subsequently prescribed, which led to cough and sputum, especially hemosputum, being well controlled. With 3 years of Kampo medicine treatment, she gained weight and her hemosputum disappeared. High-resolution computed tomography images showed improvement in her lung condition, and her sputum smear culture was negative for acid-fast bacillus.Conclusion: Various kinds of Kampo medicines have been used empirically for NTM-PD in Japan. A literature review from 1992 to 2020 showed that hozais, in particular, seem to be key drugs for the treatment of host NTM-PD risk factors. Kampo medicines can contribute to comprehensive treatment for NTM-PD management that does not rely solely on antibacterial drugs.Tomoko SuzukiTomoko SuzukiKazushi UnedaRyutaro AoyagiTakehito KobayashiTadamichi MitsumaHidetomo NakamotoFrontiers Media S.A.articlenon-tuberculous mycobacterium-pulmonary disease (NTM-PD)Kampo medicinehozaibukuryoshigyakutohochuekkitoNutrition. Foods and food supplyTX341-641ENFrontiers in Nutrition, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	non-tuberculous mycobacterium-pulmonary disease (NTM-PD) Kampo medicine hozai bukuryoshigyakuto hochuekkito Nutrition. Foods and food supply TX341-641
spellingShingle	non-tuberculous mycobacterium-pulmonary disease (NTM-PD) Kampo medicine hozai bukuryoshigyakuto hochuekkito Nutrition. Foods and food supply TX341-641 Tomoko Suzuki Tomoko Suzuki Kazushi Uneda Ryutaro Aoyagi Takehito Kobayashi Tadamichi Mitsuma Hidetomo Nakamoto Case Report: Kampo Medicine for Non-tuberculous Mycobacterium Pulmonary Disease
description	Background: While the number of pulmonary tuberculosis cases has decreased, increase in non-tuberculous mycobacterium pulmonary disease (NTM-PD) is a global problem. Guideline-based therapy for NTM-PD sometimes causes complications that prevent treatment completion, and there are many cases of relapse even if the treatment can be completed. In addition to antibacterial treatment, care of host risk factors, such as aging, lean physique and immunosuppressive state, is also very important for the management of NTM-PD. In Japan, Kampo medicine, a traditional Japanese herbal formulation, used alone or in combination with standard multidrug therapy for NTM-PD, has been found to be effective for such cases.Case Presentation: A 77-year-old lean woman had been diagnosed with Mycobacterium intracellulare pulmonary infection 6 years earlier, and had received the standard multidrug treatment 5 years later at a former hospital due to worsening of her symptoms of cough, breathlessness and hemoptysis. However, the treatment was discontinued within a year due to the development of adverse events. She refused the guideline-based antibacterial treatment, and asked for Kampo medicine instead. Bukuryoshigyakuto was subsequently prescribed, which led to cough and sputum, especially hemosputum, being well controlled. With 3 years of Kampo medicine treatment, she gained weight and her hemosputum disappeared. High-resolution computed tomography images showed improvement in her lung condition, and her sputum smear culture was negative for acid-fast bacillus.Conclusion: Various kinds of Kampo medicines have been used empirically for NTM-PD in Japan. A literature review from 1992 to 2020 showed that hozais, in particular, seem to be key drugs for the treatment of host NTM-PD risk factors. Kampo medicines can contribute to comprehensive treatment for NTM-PD management that does not rely solely on antibacterial drugs.
format	article
author	Tomoko Suzuki Tomoko Suzuki Kazushi Uneda Ryutaro Aoyagi Takehito Kobayashi Tadamichi Mitsuma Hidetomo Nakamoto
author_facet	Tomoko Suzuki Tomoko Suzuki Kazushi Uneda Ryutaro Aoyagi Takehito Kobayashi Tadamichi Mitsuma Hidetomo Nakamoto
author_sort	Tomoko Suzuki
title	Case Report: Kampo Medicine for Non-tuberculous Mycobacterium Pulmonary Disease
title_short	Case Report: Kampo Medicine for Non-tuberculous Mycobacterium Pulmonary Disease
title_full	Case Report: Kampo Medicine for Non-tuberculous Mycobacterium Pulmonary Disease
title_fullStr	Case Report: Kampo Medicine for Non-tuberculous Mycobacterium Pulmonary Disease
title_full_unstemmed	Case Report: Kampo Medicine for Non-tuberculous Mycobacterium Pulmonary Disease
title_sort	case report: kampo medicine for non-tuberculous mycobacterium pulmonary disease
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/22aa3bc47926464d9648ffbdcda16e0e
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Case Report: Kampo Medicine for Non-tuberculous Mycobacterium Pulmonary Disease

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