Genetics of symptom remission in outpatients with COVID-19

Abstract We conducted a genome-wide association study of time to remission of COVID-19 symptoms in 1723 outpatients with at least one risk factor for disease severity from the COLCORONA clinical trial. We found a significant association at 5p13.3 (rs1173773; P = 4.94 × 10–8) near the natriuretic pep...

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Autores principales:	Marie-Pierre Dubé, Audrey Lemaçon, Amina Barhdadi, Louis-Philippe Lemieux Perreault, Essaïd Oussaïd, Géraldine Asselin, Sylvie Provost, Maxine Sun, Johanna Sandoval, Marc-André Legault, Ian Mongrain, Anick Dubois, Diane Valois, Emma Dedelis, Jennifer Lousky, Julie Choi, Elisabeth Goulet, Christiane Savard, Lea-Mei Chicoine, Mariève Cossette, Malorie Chabot-Blanchet, Marie-Claude Guertin, Simon de Denus, Nadia Bouabdallaoui, Richard Marchand, Zohar Bassevitch, Anna Nozza, Daniel Gaudet, Philippe L. L’Allier, Julie Hussin, Guy Boivin, David Busseuil, Jean-Claude Tardif
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/22ad144ba1304827b38809d5ea8a9606
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spelling	oai:doaj.org-article:22ad144ba1304827b38809d5ea8a96062021-12-02T15:49:35ZGenetics of symptom remission in outpatients with COVID-1910.1038/s41598-021-90365-62045-2322https://doaj.org/article/22ad144ba1304827b38809d5ea8a96062021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90365-6https://doaj.org/toc/2045-2322Abstract We conducted a genome-wide association study of time to remission of COVID-19 symptoms in 1723 outpatients with at least one risk factor for disease severity from the COLCORONA clinical trial. We found a significant association at 5p13.3 (rs1173773; P = 4.94 × 10–8) near the natriuretic peptide receptor 3 gene (NPR3). By day 15 of the study, 44%, 54% and 59% of participants with 0, 1, or 2 copies of the effect allele respectively, had symptom remission. In 851 participants not treated with colchicine (placebo), there was a significant association at 9q33.1 (rs62575331; P = 2.95 × 10–8) in interaction with colchicine (P = 1.19 × 10–5) without impact on risk of hospitalisations, highlighting a possibly shared mechanistic pathway. By day 15 of the study, 46%, 62% and 64% of those with 0, 1, or 2 copies of the effect allele respectively, had symptom remission. The findings need to be replicated and could contribute to the biological understanding of COVID-19 symptom remission.Marie-Pierre DubéAudrey LemaçonAmina BarhdadiLouis-Philippe Lemieux PerreaultEssaïd OussaïdGéraldine AsselinSylvie ProvostMaxine SunJohanna SandovalMarc-André LegaultIan MongrainAnick DuboisDiane ValoisEmma DedelisJennifer LouskyJulie ChoiElisabeth GouletChristiane SavardLea-Mei ChicoineMariève CossetteMalorie Chabot-BlanchetMarie-Claude GuertinSimon de DenusNadia BouabdallaouiRichard MarchandZohar BassevitchAnna NozzaDaniel GaudetPhilippe L. L’AllierJulie HussinGuy BoivinDavid BusseuilJean-Claude TardifNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marie-Pierre Dubé Audrey Lemaçon Amina Barhdadi Louis-Philippe Lemieux Perreault Essaïd Oussaïd Géraldine Asselin Sylvie Provost Maxine Sun Johanna Sandoval Marc-André Legault Ian Mongrain Anick Dubois Diane Valois Emma Dedelis Jennifer Lousky Julie Choi Elisabeth Goulet Christiane Savard Lea-Mei Chicoine Mariève Cossette Malorie Chabot-Blanchet Marie-Claude Guertin Simon de Denus Nadia Bouabdallaoui Richard Marchand Zohar Bassevitch Anna Nozza Daniel Gaudet Philippe L. L’Allier Julie Hussin Guy Boivin David Busseuil Jean-Claude Tardif Genetics of symptom remission in outpatients with COVID-19
description	Abstract We conducted a genome-wide association study of time to remission of COVID-19 symptoms in 1723 outpatients with at least one risk factor for disease severity from the COLCORONA clinical trial. We found a significant association at 5p13.3 (rs1173773; P = 4.94 × 10–8) near the natriuretic peptide receptor 3 gene (NPR3). By day 15 of the study, 44%, 54% and 59% of participants with 0, 1, or 2 copies of the effect allele respectively, had symptom remission. In 851 participants not treated with colchicine (placebo), there was a significant association at 9q33.1 (rs62575331; P = 2.95 × 10–8) in interaction with colchicine (P = 1.19 × 10–5) without impact on risk of hospitalisations, highlighting a possibly shared mechanistic pathway. By day 15 of the study, 46%, 62% and 64% of those with 0, 1, or 2 copies of the effect allele respectively, had symptom remission. The findings need to be replicated and could contribute to the biological understanding of COVID-19 symptom remission.
format	article
author	Marie-Pierre Dubé Audrey Lemaçon Amina Barhdadi Louis-Philippe Lemieux Perreault Essaïd Oussaïd Géraldine Asselin Sylvie Provost Maxine Sun Johanna Sandoval Marc-André Legault Ian Mongrain Anick Dubois Diane Valois Emma Dedelis Jennifer Lousky Julie Choi Elisabeth Goulet Christiane Savard Lea-Mei Chicoine Mariève Cossette Malorie Chabot-Blanchet Marie-Claude Guertin Simon de Denus Nadia Bouabdallaoui Richard Marchand Zohar Bassevitch Anna Nozza Daniel Gaudet Philippe L. L’Allier Julie Hussin Guy Boivin David Busseuil Jean-Claude Tardif
author_facet	Marie-Pierre Dubé Audrey Lemaçon Amina Barhdadi Louis-Philippe Lemieux Perreault Essaïd Oussaïd Géraldine Asselin Sylvie Provost Maxine Sun Johanna Sandoval Marc-André Legault Ian Mongrain Anick Dubois Diane Valois Emma Dedelis Jennifer Lousky Julie Choi Elisabeth Goulet Christiane Savard Lea-Mei Chicoine Mariève Cossette Malorie Chabot-Blanchet Marie-Claude Guertin Simon de Denus Nadia Bouabdallaoui Richard Marchand Zohar Bassevitch Anna Nozza Daniel Gaudet Philippe L. L’Allier Julie Hussin Guy Boivin David Busseuil Jean-Claude Tardif
author_sort	Marie-Pierre Dubé
title	Genetics of symptom remission in outpatients with COVID-19
title_short	Genetics of symptom remission in outpatients with COVID-19
title_full	Genetics of symptom remission in outpatients with COVID-19
title_fullStr	Genetics of symptom remission in outpatients with COVID-19
title_full_unstemmed	Genetics of symptom remission in outpatients with COVID-19
title_sort	genetics of symptom remission in outpatients with covid-19
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/22ad144ba1304827b38809d5ea8a9606
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Genetics of symptom remission in outpatients with COVID-19

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