Origins of 1/f-like tissue oxygenation fluctuations in the murine cortex.

The concentration of oxygen in the brain spontaneously fluctuates, and the distribution of power in these fluctuations has a 1/f-like spectra, where the power present at low frequencies of the power spectrum is orders of magnitude higher than at higher frequencies. Though these oscillations have bee...

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Autores principales:	Qingguang Zhang, Kyle W Gheres, Patrick J Drew
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/22aef538fa2c485bb78f70398ce61eed
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spelling	oai:doaj.org-article:22aef538fa2c485bb78f70398ce61eed2021-12-02T19:54:41ZOrigins of 1/f-like tissue oxygenation fluctuations in the murine cortex.1544-91731545-788510.1371/journal.pbio.3001298https://doaj.org/article/22aef538fa2c485bb78f70398ce61eed2021-07-01T00:00:00Zhttps://doi.org/10.1371/journal.pbio.3001298https://doaj.org/toc/1544-9173https://doaj.org/toc/1545-7885The concentration of oxygen in the brain spontaneously fluctuates, and the distribution of power in these fluctuations has a 1/f-like spectra, where the power present at low frequencies of the power spectrum is orders of magnitude higher than at higher frequencies. Though these oscillations have been interpreted as being driven by neural activity, the origin of these 1/f-like oscillations is not well understood. Here, to gain insight of the origin of the 1/f-like oxygen fluctuations, we investigated the dynamics of tissue oxygenation and neural activity in awake behaving mice. We found that oxygen signal recorded from the cortex of mice had 1/f-like spectra. However, band-limited power in the local field potential did not show corresponding 1/f-like fluctuations. When local neural activity was suppressed, the 1/f-like fluctuations in oxygen concentration persisted. Two-photon measurements of erythrocyte spacing fluctuations and mathematical modeling show that stochastic fluctuations in erythrocyte flow could underlie 1/f-like dynamics in oxygenation. These results suggest that the discrete nature of erythrocytes and their irregular flow, rather than fluctuations in neural activity, could drive 1/f-like fluctuations in tissue oxygenation.Qingguang ZhangKyle W GheresPatrick J DrewPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Biology, Vol 19, Iss 7, p e3001298 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Qingguang Zhang Kyle W Gheres Patrick J Drew Origins of 1/f-like tissue oxygenation fluctuations in the murine cortex.
description	The concentration of oxygen in the brain spontaneously fluctuates, and the distribution of power in these fluctuations has a 1/f-like spectra, where the power present at low frequencies of the power spectrum is orders of magnitude higher than at higher frequencies. Though these oscillations have been interpreted as being driven by neural activity, the origin of these 1/f-like oscillations is not well understood. Here, to gain insight of the origin of the 1/f-like oxygen fluctuations, we investigated the dynamics of tissue oxygenation and neural activity in awake behaving mice. We found that oxygen signal recorded from the cortex of mice had 1/f-like spectra. However, band-limited power in the local field potential did not show corresponding 1/f-like fluctuations. When local neural activity was suppressed, the 1/f-like fluctuations in oxygen concentration persisted. Two-photon measurements of erythrocyte spacing fluctuations and mathematical modeling show that stochastic fluctuations in erythrocyte flow could underlie 1/f-like dynamics in oxygenation. These results suggest that the discrete nature of erythrocytes and their irregular flow, rather than fluctuations in neural activity, could drive 1/f-like fluctuations in tissue oxygenation.
format	article
author	Qingguang Zhang Kyle W Gheres Patrick J Drew
author_facet	Qingguang Zhang Kyle W Gheres Patrick J Drew
author_sort	Qingguang Zhang
title	Origins of 1/f-like tissue oxygenation fluctuations in the murine cortex.
title_short	Origins of 1/f-like tissue oxygenation fluctuations in the murine cortex.
title_full	Origins of 1/f-like tissue oxygenation fluctuations in the murine cortex.
title_fullStr	Origins of 1/f-like tissue oxygenation fluctuations in the murine cortex.
title_full_unstemmed	Origins of 1/f-like tissue oxygenation fluctuations in the murine cortex.
title_sort	origins of 1/f-like tissue oxygenation fluctuations in the murine cortex.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/22aef538fa2c485bb78f70398ce61eed
work_keys_str_mv	AT qingguangzhang originsof1fliketissueoxygenationfluctuationsinthemurinecortex AT kylewgheres originsof1fliketissueoxygenationfluctuationsinthemurinecortex AT patrickjdrew originsof1fliketissueoxygenationfluctuationsinthemurinecortex
_version_	1718375888601481216

Origins of 1/f-like tissue oxygenation fluctuations in the murine cortex.

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